Search Results - "Fatokun, Amos A"

Parthanatos: mitochondrial‐linked mechanisms and therapeutic opportunities by Fatokun, Amos A, Dawson, Valina L, Dawson, Ted M

“…Cells die by a variety of mechanisms. Terminally differentiated cells such as neurones die in a variety of disorders, in part, via parthanatos, a process…”
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Kola nut from Cola nitida vent. Schott administered to pregnant rats induces histological alterations in pups' cerebellum by Atiba, Foluso A, Fatokun, Amos A, Imosemi, Innocent O, Malomo, Adefolarin O

“…Kola nut (from Cola nitida) is popular in Nigeria and West Africa and is commonly consumed by pregnant women during the first trimester to alleviate morning…”
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Peristrophe bicalyculata (Retz) Nees contains principles that are cytotoxic to cancer cells and induce caspase-mediated, intrinsic apoptotic death through oxidative stress, mitochondrial depolarisation and DNA damage by Abdulazeez, Mansurah A., Jasim, Hiba A., Bashir, Musa, Ross, Kehinde, Fatokun, Amos A.

“…The plant Peristrophe bicalyculata (Retz) Nees is used for the treatment of cancer. While its leaf extracts have been shown to inhibit the growth of some…”
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Targeted Lipid-Based Drug Delivery Systems for Lung Cancer Therapy by Apostolou, Maria, Fatokun, Amos A, Assi, Sulaf, Khan, Iftikhar

“…The aim of this study was to review the literature to explore the lipid-based drug delivery systems that have been investigated for improved treatment of lung…”
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The Use of Micro-Ribbons and Micro-Fibres in the Formulation of 3D Printed Fast Dissolving Oral Films by Algellay, Marwan, Roberts, Matthew, Bosworth, Lucy, Sarker, Satyajit D, Fatokun, Amos A, Ehtezazi, Touraj

“…Three-dimensional printing (3DP) allows production of novel fast dissolving oral films (FDFs). However, mechanical properties of the films may not be desirable…”
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Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles by Islam, Yamir, Leach, Andrew G., Smith, Jayden, Pluchino, Stefano, Coxon, Christopher R., Sivakumaran, Muttuswamy, Downing, James, Fatokun, Amos A., Teixidò, Meritxell, Ehtezazi, Touraj

“…The prevalence of neurological/neurodegenerative diseases, such as Alzheimer's disease is known to be increasing due to an aging population and is anticipated…”
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Shikonin and Juglone Inhibit Mycobacterium tuberculosis Low-Molecular-Weight Protein Tyrosine Phosphatase a (Mt-PTPa) by Sulyman, Abdulhakeem O., Fulcher, Jessie, Crossley, Samuel, Fatokun, Amos A., Olorunniji, Femi J.

“…Low-molecular-weight protein tyrosine phosphatases (LMW-PTPs) are involved in promoting the intracellular survival of Mycobacterium tuberculosis (Mtb), the…”
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Editorial: Translational Research and Drug Repurposing for Non-Communicable Diseases (NCDs) by Akindele, Abidemi J, Fatokun, Amos A, Uzochukwu, Ikemefuna C, Steenkamp, Vanessa, Agyare, Christian, Familoni, Oluwole, James, Margaret O

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Pentagalloylglucose, isolated from the leaf extract of Anacardium occidentale L., could elicit rapid and selective cytotoxicity in cancer cells by Taiwo, Bamigboye J, Popoola, Temidayo D, van Heerden, Fanie R, Fatokun, Amos A

“…The leaf of Anacardium occidentale L. has been a component of many herbal recipes in South-Western Nigeria. The work reported herein, therefore, explored the…”
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Ceibinin, a new positional isomer of mangiferin from the inflorescence of Ceiba pentandra (Bombacaceae), elicits similar antioxidant effect but no anti-inflammatory potential compared to mangiferin by Taiwo, Bamigboye J., Miller, Alex H., Fielding, Alistair J., Sarker, Satyajit D., van Heerden, Fannie R., Fatokun, Amos A.

“…Ceiba pentandra (L.) Gaertn. (Bombacaceae) is popular for the quality of its wood. However, its leaf, stem bark and root bark have been popular in…”
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Potent Nrf2-inducing, antioxidant, and anti-inflammatory effects and identification of constituents validate the anti-cancer use of Uvaria chamae and Olax subscorpioidea by Popoola, Temidayo D, Guetchueng, Stephanie T, Ritchie, Kenneth J, Awodele, Olufunsho, Dempster, Nicola M, Akinloye, Oluyemi, Sarker, Satyajit D, Fatokun, Amos A

“…Uvaria chamae (UC) and Olax subscorpioidea (OS) roots are included in traditional anti-cancer remedies and some studies have identified their…”
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Cola rostrata K. Schum. constituents induce cytotoxicity through reactive oxygen species generation and mitochondrial membrane depolarisation by Ajayi, Babatunde E, Oboh, Bola, Minari, Joseph B, Sexton, Darren W, Sarker, Satyajit D, Fatokun, Amos A

“…While the traditional use of in treating illnesses and diseases has not been reported, the presence of cytotoxic principles has been reported in…”
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Catalytic Activities of Multimeric G-Quadruplex DNAzymes by Raphael I. Adeoye, Dunsin S. Osalaye, Theresia K. Ralebitso-Senior, Amanda Boddis, Amanda J. Reid, Amos A. Fatokun, Andrew K. Powell, Sylvia O. Malomo, Femi J. Olorunniji

“…G-quadruplex DNAzymes are short DNA aptamers with repeating G4 quartets bound in a non-covalent complex with hemin. These G4/Hemin structures exhibit versatile…”
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Synthesis, characterization and anti-cancer studies of Mn(II), Cu(II), Zn(II) and Pt(II) dithiocarbamate complexes - crystal structures of the Cu(II) and Pt(II) complexes by Ajibade, Peter A., Fatokun, Amos A., Andrew, Fartisincha P.

“…[Display omitted] •Mn(II), Cu(II), Zn(II) and Pt(II) dithiocarmabarete complexes were prepared and characterized.•Molecular structures of the Cu(II) (C2) and…”
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Fluoxetine selectively induces p53-independent apoptosis in human colorectal cancer cells by Marcinkute, Monika, Afshinjavid, Saeed, Fatokun, Amos A., Javid, Farideh A.

“…Fluoxetine has been shown to induce anti-tumour activity. The aim of this study was to determine the effect of fluoxetine on HCT116+/+ and p53 gene-depleted…”
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Cell death in rat cerebellar granule neurons induced by hydrogen peroxide in vitro: Mechanisms and protection by adenosine receptor ligands by Fatokun, Amos A, Stone, Trevor W, Smith, Robert A

“…Abstract Oxidative stress, resulting from excessive production of reactive oxygen species (ROS), is a pathological state that causes profound cellular damage…”
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Cytotoxic triterpenoid saponins from the root of Olax subscorpioidea Oliv. (Olacaceae) by Adekunle, Yemi A., Samuel, Babatunde B., Nahar, Lutfun, Fatokun, Amos A., Sarker, Satyajit D.

“…Bioactivity-guided phytochemical fractionation of the methanol extract of Olax subscorpioidea root has led to the isolation of six triterpenes. Three of these…”
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Palladium(II) complexes of tridentate bis(benzazole) ligands: Structural, substitution kinetics, DNA interactions and cytotoxicity studies by Omondi, Reinner O., Bellam, Rajesh, Ojwach, Stephen O., Jaganyi, Deogratius, Fatokun, Amos A.

“…Reactions of 2,6-bis(benzimidazol-2-yl)pyridine (L1), 2,6-bis(benzoxazol-2-yl)pyridine (L2), and 2,6-bis(benzothiazol-2-yl)pyridine (L3) with [Pd(NCMe)2Cl2] in…”
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Synthesis, characterization and in vitro screening for anticancer potential of Mn(II), Co(II), Cu(II), Zn(II), and Pt(II) methoxyphenyl dithiocarbamato complexes by Ajibade, Peter A., Andrew, Fartisincha P., Fatokun, Amos A., Oluwalana, Abimbola E.

“…•Metal(II) complexes of 2-(((4-methoxyphenyl)phenolyl dithiocarbamate were synthesized and characterized.•In vitro cytotoxicity screening for anticancer…”
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Synthesis, substitution kinetics, DNA/BSA binding and cytotoxicity of tridentate N^E^N (E = NH, O, S) pyrazolyl palladium(II) complexes by Omondi, Reinner O., Fadaka, Adewale O., Fatokun, Amos A., Jaganyi, Deogratius, Ojwach, Stephen O.

“…The pincer complexes, [Pd( L 1 )Cl]BF 4 ( PdL 1 ), [Pd( L 2 )Cl]BF 4 ( PdL 2 ) , [Pd( L 3 )Cl]BF 4 ( PdL 3 ), [Pd( L 4 )Cl]BF 4 ( PdL 4 ) were prepared by…”
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