Search Results - "Fath, Donna M."

Genome-wide rare variant analysis for thousands of phenotypes in over 70,000 exomes from two cohorts by Cirulli, Elizabeth T., White, Simon, Read, Robert W., Elhanan, Gai, Metcalf, William J., Tanudjaja, Francisco, Fath, Donna M., Sandoval, Efren, Isaksson, Magnus, Schlauch, Karen A., Grzymski, Joseph J., Lu, James T., Washington, Nicole L.

“…Understanding the impact of rare variants is essential to understanding human health. We analyze rare (MAF < 0.1%) variants against 4264 phenotypes in 49,960…”
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Blood-Based Liquid Biopsy for Comprehensive Cancer Genomic Profiling Using Next-Generation Sequencing: An Emerging Paradigm for Non-invasive Cancer Detection and Management in Dogs by Kruglyak, Kristina M, Chibuk, Jason, McLennan, Lisa, Nakashe, Prachi, Hernandez, Gilberto E, Motalli-Pepio, Rita, Fath, Donna M, Tynan, John A, Holtvoigt, Lauren E, Chorny, Ilya, Grosu, Daniel S, Tsui, Dana W Y, Flory, Andi

“…This proof-of-concept study demonstrates that blood-based liquid biopsy using next generation sequencing of cell-free DNA can non-invasively detect multiple…”
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Histone Deacetylase Inhibitors Repress the Transactivation Potential of Hypoxia-inducible Factors Independently of Direct Acetylation of HIF-α by Fath, Donna M., Kong, Xianguo, Liang, Dongming, Lin, Zhao, Chou, Andrew, Jiang, Yubao, Fang, Jie, Caro, Jaime, Sang, Nianli

“…Hypoxia-inducible factors (HIFs) are heterodimeric transcription factors regulating the oxygen supply, glucose metabolism, and angiogenesis. HIF function…”
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Histone deacetylase inhibitors synergize p300 autoacetylation that regulates its transactivation activity and complex formation by STIEHL, Daniel P, PATH, Donna M, DONGMING LIANG, YUBAO JIANG, NIANLI SANG

“…p300/cyclic AMP-responsive element binding protein-binding protein (CBP) are general coactivators for multiple transcription factors involved in various…”
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DNA-dependent protein kinase activity is not required for immunoglobulin class switching by Bosma, Gayle C, Kim, Jiyoon, Urich, Teresa, Fath, Donna M, Cotticelli, Maria G, Ruetsch, Norman R, Radic, Marko Z, Bosma, Melvin J

“…Class switch recombination (CSR), similar to V(D)J recombination, is thought to involve DNA double strand breaks and repair by the nonhomologous end-joining…”
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A gene highly expressed in tumor cells encodes novel structure proteins by NIANLI SANG, FATH, Donna M, GIORDANO, Antonio

“…We isolated several related but distinct cDNA clones encoding novel structure proteins (NSP) when screening a cDNA library. Analysis revealed that these cDNAs…”
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Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy" blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study by Andi Flory, Kristina M Kruglyak, John A Tynan, Lisa M McLennan, Jill M Rafalko, Patrick Christian Fiaux, Gilberto E Hernandez, Francesco Marass, Prachi Nakashe, Carlos A Ruiz-Perez, Donna M Fath, Thuy Jennings, Rita Motalli-Pepio, Kate Wotrang, Angela L McCleary-Wheeler, Susan Lana, Brenda Phillips, Brian K Flesner, Nicole F Leibman, Tracy LaDue, Chelsea D Tripp, Brenda L Coomber, J Paul Woods, Mairin Miller, Sean W Aiken, Amber Wolf-Ringwall, Antonella Borgatti, Kathleen Kraska, Christopher B Thomson, Alane Kosanovich Cahalane, Rebecca L Murray, William C Kisseberth, Maria A Camps-Palau, Franck Floch, Claire Beaudu-Lange, Aurélia Klajer-Peres, Olivier Keravel, Luc-André Fribourg-Blanc, Pascale Chicha Mazetier, Angelo Marco, Molly B McLeod, Erin Portillo, Terry S Clark, Scott Judd, C Kirk Feinberg, Marie Benitez, Candace Runyan, Lindsey Hackett, Scott Lafey, Danielle Richardson, Sarah Vineyard, Mary Tefend Campbell, Nilesh Dharajiya, Taylor J Jensen, Dirk van den Boom, Luis A Diaz, Daniel S Grosu, Arthur Polk, Kalle Marsal, Susan Cho Hicks, Katherine M Lytle, Lauren Holtvoigt, Jason Chibuk, Ilya Chorny, Dana W Y Tsui

“…Cancer is the leading cause of death in dogs, yet there are no established screening paradigms for early detection. Liquid biopsy methods that interrogate…”
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Histone Deacetylase Inhibitors Repress the Transactivation Potential of Hypoxia-inducible Factors Independently of Direct Acetylation of HIF-Î by Donna M. Fath, Xianguo Kong, Dongming Liang, Zhao Lin, Andrew Chou, Yubao Jiang, Jie Fang, Jaime Caro, Nianli Sang

“…Hypoxia-inducible factors (HIFs) are heterodimeric transcription factors regulating the oxygen supply, glucose metabolism, and angiogenesis. HIF function…”
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Histone Deacetylase Inhibitors Repress the Transactivation Potential of Hypoxia-inducible Factors Independently of Direct Acetylation of HIF-αS by Fath, Donna M., Kong, Xianguo, Liang, Dongming, Lin, Zhao, Chou, Andrew, Jiang, Yubao, Fang, Jie, Caro, Jaime, Sang, Nianli

“…Hypoxia-inducible factors (HIFs) are heterodimeric transcription factors regulating the oxygen supply, glucose metabolism, and angiogenesis. HIF function…”
Get full text