Search Results - "Fatanmi, Oluseyi"

Gamma-tocotrienol, a radiation countermeasure, reverses proteomic changes in serum following total-body gamma irradiation in mice by Rosen, Elliot, Fatanmi, Oluseyi O., Wise, Stephen Y., Rao, V. Ashutosh, Singh, Vijay K.

“…Radiological incidents or terrorist attacks would likely expose civilians and military personnel to high doses of ionizing radiation, leading to the…”
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Transcriptome profile changes in the jejunum of nonhuman primates exposed to supralethal dose of total- or partial-body radiation by Vellichirammal, Neetha Nanoth, Sethi, Sahil, Avuthu, Nagavardhini, Wise, Stephen Y, Carpenter, Alana D, Fatanmi, Oluseyi O, Guda, Chittibabu, Singh, Vijay K

“…The risk of exposure of the general public or military personnel to high levels of ionizing radiation from nuclear weapons or radiological accidents is a dire…”
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Cross-species conserved miRNA as biomarker of radiation injury over a wide dose range using nonhuman primate model by Chakraborty, Nabarun, Dimitrov, George, Kanan, Swapna, Lawrence, Alexander, Moyler, Candance, Gautam, Aarti, Fatanmi, Oluseyi O, Wise, Stephen Y, Carpenter, Alana D, Hammamieh, Rasha, Singh, Vijay K

“…Multiple accidents in nuclear power plants and the growing concerns about the misuse of radiation exposure in warfare have called for the rapid determination…”
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Pharmacokinetic and Metabolomic Studies with BIO 300, a Nanosuspension of Genistein, in a Nonhuman Primate Model by Cheema, Amrita K, Mehta, Khyati Y, Santiago, Paola T, Fatanmi, Oluseyi O, Kaytor, Michael D, Singh, Vijay K

“…Genistein is a naturally occurring phytoestrogen isoflavone and is the active drug ingredient in BIO 300, a radiation countermeasure under advanced development…”
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Plasma Derived Exosomal Biomarkers of Exposure to Ionizing Radiation in Nonhuman Primates by Cheema, Amrita K, Hinzman, Charles P, Mehta, Khyati Y, Hanlon, Briana K, Garcia, Melissa, Fatanmi, Oluseyi O, Singh, Vijay K

“…Exposure to ionizing radiation induces a cascade of molecular events that ultimately impact endogenous metabolism. Qualitative and quantitative…”
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Transcriptome of rhesus macaque (Macaca mulatta) exposed to total-body irradiation by Li, Yaoxiang, Singh, Jatinder, Varghese, Rency, Zhang, Yubo, Fatanmi, Oluseyi O., Cheema, Amrita K., Singh, Vijay K.

“…The field of biodosimetry has seen a paradigm shift towards an increased use of molecular phenotyping technologies including omics and miRNA, in addition to…”
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A Metabolomic and Lipidomic Serum Signature from Nonhuman Primates Administered with a Promising Radiation Countermeasure, Gamma-Tocotrienol by Cheema, Amrita K, Mehta, Khyati Y, Fatanmi, Oluseyi O, Wise, Stephen Y, Hinzman, Charles P, Wolff, Josh, Singh, Vijay K

“…The development of radiation countermeasures for acute radiation syndrome (ARS) has been underway for the past six decades, leading to the identification of…”
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Identification of Novel Biomarkers for Acute Radiation Injury Using Multiomics Approach and Nonhuman Primate Model by Cheema, Amrita K., Li, Yaoxiang, Moulton, Joanna, Girgis, Michael, Wise, Stephen Y., Carpenter, Alana, Fatanmi, Oluseyi O., Singh, Vijay K.

“…The availability of validated biomarkers to assess radiation exposure and to assist in developing medical countermeasures remains an unmet need. We used a…”
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Proteomic analysis of plasma at the preterminal stage of rhesus nonhuman primates exposed to a lethal total-body dose of gamma-radiation by Carpenter, Alana D., Fatanmi, Oluseyi O., Wise, Stephen Y., Tyburski, John B., Cheema, Amrita K., Singh, Vijay K.

“…The identification and validation of radiation biomarkers is critical for assessing the radiation dose received in exposed individuals and for developing…”
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Analysis of the metabolomic profile in serum of irradiated nonhuman primates treated with Ex-Rad, a radiation countermeasure by Li, Yaoxiang, Girgis, Michael, Wise, Stephen Y., Fatanmi, Oluseyi O., Seed, Thomas M., Maniar, Manoj, Cheema, Amrita K., Singh, Vijay K.

“…To date, the United States Food and Drug Administration (FDA) has approved four drugs to mitigate hematopoietic acute radiation syndrome and all four are…”
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Serum microRNA profile of rhesus macaques following ionizing radiation exposure and treatment with a medical countermeasure, Ex-Rad by Russ, Eric, Fatanmi, Oluseyi O., Wise, Stephen Y., Carpenter, Alana D., Maniar, Manoj, Iordanskiy, Sergey, Singh, Vijay K.

“…Exposure to ionizing radiation (IR) presents a formidable clinical challenge. Total-body or significant partial-body exposure at a high dose and dose rate…”
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Determination of Lethality Curve for Cobalt-60 Gamma-Radiation Source in Rhesus Macaques Using Subject-Based Supportive Care by Singh, Vijay K., Fatanmi, Oluseyi O., Wise, Stephen Y., Carpenter, Alana D., Olsen, Cara H.

“…Well-characterized and validated animal models are required for the development of medical countermeasures (MCMs) for acute radiation syndrome to mitigate…”
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Analysis of the Proteomic Profile in Serum of Irradiated Nonhuman Primates Treated with Ex-Rad, a Radiation Medical Countermeasure by Carpenter, Alana D., Li, Yaoxiang, Janocha, Brianna L., Wise, Stephen Y., Fatanmi, Oluseyi O., Maniar, Manoj, Cheema, Amrita K., Singh, Vijay K.

“…There are currently four radiation medical countermeasures that have been approved by the United States Food and Drug Administration to mitigate hematopoietic…”
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BIO 300 Attenuates Whole Blood Transcriptome Changes in Mice Exposed to Total-Body Radiation by Serebrenik, Artur A, Fatanmi, Oluseyi O, Wise, Stephen Y, Petrus, Sarah A, Kaytor, Michael D, Singh, Vijay K

“…Development of radiation medical countermeasures under the U.S. Food and Drug Administration Animal Rule requires the capability to translate an effective…”
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Metabolomic changes in preterminal serum samples of rhesus macaques exposed to two different lethal doses of total-body gamma-radiation by Carpenter, Alana D., Empfield, Keirstyn M., Petrus, Sarah A., Fatanmi, Oluseyi O., Wise, Stephen Y., Tyburski, John B., Cheema, Amrita K., Singh, Vijay K.

“…Exposure to ionizing radiation induces cellular and molecular damage leading to a cascade of events resulting in tissue and organ injury. Our study strives to…”
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Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model by Garg, Tarun K, Garg, Sarita, Miousse, Isabelle R, Wise, Stephen Y, Carpenter, Alana D, Fatanmi, Oluseyi O, van Rhee, Frits, Singh, Vijay K, Hauer-Jensen, Martin

“…Radiation exposure causes acute damage to hematopoietic and immune cells. To date, there are no radioprotectors available to mitigate hematopoietic injury…”
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Metabolomic Studies of Tissue Injury in Nonhuman Primates Exposed to Gamma-Radiation by Cheema, Amrita K, Mehta, Khyati Y, Rajagopal, Meena U, Wise, Stephen Y, Fatanmi, Oluseyi O, Singh, Vijay K

“…Exposure to ionizing radiation induces a complex cascade of systemic and tissue-specific responses that lead to functional impairment over time in the…”
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A novel oral formulation of BIO 300 confers prophylactic radioprotection from acute radiation syndrome in mice by Singh, Vijay K., Fatanmi, Oluseyi O., Wise, Stephen Y., Carpenter, Alana, Nakamura-Peek, Sara, Serebrenik, Artur A., Kaytor, Michael D.

“…Exposure to high doses of ionizing radiation can result in hematopoietic acute radiation syndrome (H-ARS) and delayed effects of acute radiation exposure…”
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Pathology of acute sub-lethal or near-lethal irradiation of nonhuman primates prophylaxed with the nutraceutical, gamma tocotrienol by Singh, Vijay K., Wise, Stephen Y., Fatanmi, Oluseyi O., Petrus, Sarah A., Carpenter, Alana D., Lugo-Roman, Luis A., Lee, Sang-Ho, Hauer-Jensen, Martin, Seed, Thomas M.

“…Exposure to high, marginally lethal doses or higher of ionizing radiation, either intentional or accidental, results in injury to various organs. Currently,…”
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Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate by Garg, Sarita, Garg, Tarun K, Wise, Stephen Y, Fatanmi, Oluseyi O, Miousse, Isabelle R, Savenka, Alena V, Basnakian, Alexei G, Singh, Vijay K, Hauer-Jensen, Martin

“…The gastrointestinal (GI) system is highly susceptible to irradiation. Currently, there is no Food and Drug Administration (FDA)-approved medical…”
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