Search Results - "Fast, David J."

Immunomodulatory effects of Lippia sidoides extract: induction of IL-10 through cAMP and p38 MAPK-dependent mechanisms by Rajgopal, Arun, Rebhun, John F, Burns, Charlie R, Scholten, Jeffrey D, Balles, John A, Fast, David J

“…Lippia sidoides is an aromatic shrub that grows wild in the northeastern region of Brazil. In local traditional medicine, the aerial portions of this species…”
Get more information

Enzymatically derived sunflower protein hydrolysate and peptides inhibit NFκB and promote monocyte differentiation to a dendritic cell phenotype by Velliquette, Rodney A., Fast, David J., Maly, Eugene R., Alashi, Adeola M., Aluko, Rotimi E.

“…•Sunflower hydrolysate and peptides inhibited NFκB and boosted monocyte differentiation.•Novel peptides YFVP, SGRDP, MVWGP and TGSYTEGWS were…”
Get full text

Gromwell (Lithospermum erythrorhizon) root extract protects against glycation and related inflammatory and oxidative stress while offering UV absorption capability by Glynn, Kelly M., Anderson, Penny, Fast, David J., Koedam, James, Rebhun, John F., Velliquette, Rodney A.

“…Glycation and advanced glycation end products (AGE) damage skin which is compounded by AGE‐induced oxidative stress and inflammation. Lip and facial skin could…”
Get full text

Echinacea purpurea root extract inhibits TNF release in response to Pam3Csk4 in a phosphatidylinositol-3-kinase dependent manner by Fast, David J., Balles, John A., Scholten, Jeffrey D., Mulder, Timothy, Rana, Jatinder

“…[Display omitted] •A water extract of Echinacea purpurea root inhibits Pam3Csk4 stimulated TNF release.•Inhibition of TNF release by Echinacea water extract is…”
Get full text

Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related illnesses by Bohach, G A, Fast, D J, Nelson, R D, Schlievert, P M

“…Toxic-shock syndrome (TSS) is an acute onset, multiorgan illness which resembles severe scarlet fever. The illness is caused by Staphylococcus aureus strains…”
Get more information

Nitric oxide production by tumor targets in response to TNF: paradoxical correlation with susceptibility to TNF-mediated cytotoxicity without direct involvement in the cytotoxic mechanism by Fast, D J, Lynch, R C, Leu, R W

“…Tumor necrosis factor (TNF) is selectively cytotoxic for some tumor cells in vivo and in vitro. We determined whether TNF-mediated cytotoxicity for…”
Get more information

The cytoprotective benefits of a turmeric, quercetin, and rosemary blend through activation of the oxidative stress pathway by Rajgopal, Arun, Roloff, Samantha, Burns, Charlie, Fast, David, Scholten, Jeffrey

“…Background: An imbalance between oxidative and reductive processes within cells can result in oxidative stress leading to a decrease in cellular survival. Use…”
Get full text

Traditional chinese medicine ingredients Rosa damascena and Poria cocos promote phagocytosis and a dendritic cell phenotype in THP-1 cells by Roloff, Samantha, Scholten, Jeffrey, Chuang, Jennifer, Hu, Chun, Fast, David

“…Background: Rosa damascena and Poria cocos are ingredients commonly used in Traditional Chinese Medicine. R. damascena is used to promote blood circulation as…”
Get full text

Pathogenesis of candidiasis. Immunosuppression by cell wall mannan catabolites by Podzorski, R P, Herron, M J, Fast, D J, Nelson, R D

“…Candida albicans cell wall mannan polysaccharide has an ability to negatively influence cell-mediated immune function. We have attempted to identify the…”
Get more information

Tumor target-derived soluble factor synergizes with IFN-gamma and IL-2 to activate macrophages for tumor necrosis factor and nitric oxide production to mediate cytotoxicity of the same target by Jiang, H, Stewart, CA, Fast, DJ, Leu, RW

“…Inflammatory mouse peritoneal macrophages were activated by IFN-gamma in synergy with IL-2 or Lipid A to mediate TNF production for autocrine generation of…”
Get full text

The muramyl dipeptide analog GMTP-N-DPG preferentially induces cellular immunity to soluble antigens by Fast, David J., Vosika, Gerald J.

“…GMTP-N-DPG ( N-acetylglucosaminyl- N-acetylmuramyl- l-alanyl- d-isoglutamyl- l-alanyl-dipalmitoylpropylamide) is a lipophilic derivative of the immunologically…”
Get full text

Mechanistic differences between migration inhibitory factor (MIF) and IFN-gamma for macrophage activation. MIF and IFN-gamma synergize with lipid A to mediate migration inhibition but only IFN-gamma induces production of TNF-alpha and nitric oxide by Herriott, MJ, Jiang, H, Stewart, CA, Fast, DJ, Leu, RW

“…Previously we found that murine macrophage migration inhibition (MMI) was mediated by IFN-gamma-priming and lipid A triggering. With the recent availability of…”
Get full text

IFN-gamma differentially modulates the susceptibility of L1210 and P815 tumor targets for macrophage-mediated cytotoxicity. Role of macrophage- target interaction coupled to nitric oxide generation, but independent of tumor necrosis factor production by Leu, RW, Leu, NR, Shannon, BJ, Fast, DJ

“…IFN-gamma primes murine macrophages to render them responsive for triggering by subactivating concentrations of bacterial LPS to mediate nonspecific tumor…”
Get full text

Transfection of L929 Cells with Complement Subcomponent C1q B-Chain Antisense cDNA Inhibits Tumor Necrosis Factor-α Binding to Mediate Cytotoxicity and Nitric Oxide Generation by Jiang, Hong, Stewart, Charles A., Tan, Shi-yu, Fast, David J., Rummage, John A., Leu, Richard W.

“…The role of complement subcomponent C1q in the modulation of TNF-α binding to L929 cells to mediate cytotoxicity and nitric oxide (NO) generation was…”
Get full text

Reconstitution of a deficiency of AKR mouse macrophages for their response to lipid A activation for tumor cytotoxicity by complement subcomponent C1q: role of IFN-gamma by Leu, RW, Zhou, AQ, Rummage, J, Fast, DJ, Shannon, BJ

“…C5-deficient AKR mouse macrophages were initially found to be refractory to activation by lipid A to mediate tumor cytotoxicity for P815 mastocytoma or L1210…”
Get full text

Inhibitor of C1q secretion suppresses the macrophage response to lipid A for nitric oxide but not for TNF production: evidence for a role of C1q in autocrine binding of TNF by Leu, R W, Stewart, C A, Herriott, M J, Fast, D J, Rummage, J A

“…Studies were designed to further define the modulatory role of complement subcomponent C1q in macrophage activation by Lipid A to mediate production of TNF and…”
Get more information

Cyclosporin A inhibits nitric oxide production by L929 cells in response to tumor necrosis factor and interferon-gamma by Fast, D J, Lynch, R C, Leu, R W

“…We recently reported that tumor necrosis factor (TNF) induced the production of nitric oxide (NO) by TNF-sensitive, but not-resistant, tumor cells…”
Get more information

Tumor-derived recognition factor (TDRF) induces production of TNF-α by murine macrophages, but requires synergy with IFN-γ alone or in combination with IL-2 to induce nitric oxide synthase by Jiang, Hong, Stewart, Charles A., Fast, David J., Leu, Richard W.

“…A constitutively produced soluble activity, designated tumor-derived recognition factor (TDRF), from L1210, P815 and EL4 tumor targets, was previously shown to…”
Get full text