Search Results - "Fassan, Matteo"

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers by Vlachogiannis, Georgios, Hedayat, Somaieh, Vatsiou, Alexandra, Jamin, Yann, Fernández-Mateos, Javier, Khan, Khurum, Lampis, Andrea, Eason, Katherine, Huntingford, Ian, Burke, Rosemary, Rata, Mihaela, Koh, Dow-Mu, Tunariu, Nina, Collins, David, Hulkki-Wilson, Sanna, Ragulan, Chanthirika, Spiteri, Inmaculada, Moorcraft, Sing Yu, Chau, Ian, Rao, Sheela, Watkins, David, Fotiadis, Nicos, Bali, Maria, Darvish-Damavandi, Mahnaz, Lote, Hazel, Eltahir, Zakaria, Smyth, Elizabeth C, Begum, Ruwaida, Clarke, Paul A, Hahne, Jens C, Dowsett, Mitchell, de Bono, Johann, Workman, Paul, Sadanandam, Anguraj, Fassan, Matteo, Sansom, Owen J, Eccles, Suzanne, Starling, Naureen, Braconi, Chiara, Sottoriva, Andrea, Robinson, Simon P, Cunningham, David, Valeri, Nicola

“…Patient-derived organoids (PDOs) have recently emerged as robust preclinical models; however, their potential to predict clinical outcomes in patients has…”
Get full text

HER2 heterogeneity in gastric/gastroesophageal cancers: From benchside to practice by Grillo, Federica, Fassan, Matteo, Sarocchi, Francesca, Fiocca, Roberto, Mastracci, Luca

“…HER2 is overexpressed in approximately 10%-20% of gastric and gastroesophageal junction carcinomas. In these types of cancer, accurate assessment of HER2…”
Get full text

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4 by Zanconato, Francesca, Battilana, Giusy, Forcato, Mattia, Filippi, Letizia, Azzolin, Luca, Manfrin, Andrea, Quaranta, Erika, Di Biagio, Daniele, Sigismondo, Gianluca, Guzzardo, Vincenza, Lejeune, Pascale, Haendler, Bernard, Krijgsveld, Jeroen, Fassan, Matteo, Bicciato, Silvio, Cordenonsi, Michelangelo, Piccolo, Stefano

“…Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional addictions that may be therapeutically exploited. Yet, the…”
Get full text

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ by Chang, Lei, Azzolin, Luca, Di Biagio, Daniele, Zanconato, Francesca, Battilana, Giusy, Lucon Xiccato, Romy, Aragona, Mariaceleste, Giulitti, Stefano, Panciera, Tito, Gandin, Alessandro, Sigismondo, Gianluca, Krijgsveld, Jeroen, Fassan, Matteo, Brusatin, Giovanna, Cordenonsi, Michelangelo, Piccolo, Stefano

“…Inactivation of ARID1A and other components of the nuclear SWI/SNF protein complex occurs at very high frequencies in a variety of human malignancies,…”
Get full text

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties by Panciera, Tito, Citron, Anna, Di Biagio, Daniele, Battilana, Giusy, Gandin, Alessandro, Giulitti, Stefano, Forcato, Mattia, Bicciato, Silvio, Panzetta, Valeria, Fusco, Sabato, Azzolin, Luca, Totaro, Antonio, Dei Tos, Angelo Paolo, Fassan, Matteo, Vindigni, Vincenzo, Bassetto, Franco, Rosato, Antonio, Brusatin, Giovanna, Cordenonsi, Michelangelo, Piccolo, Stefano

“…Defining the interplay between the genetic events and microenvironmental contexts necessary to initiate tumorigenesis in normal cells is a central endeavour in…”
Get full text

Tumor mutation burden: from comprehensive mutational screening to the clinic by Galuppini, Francesca, Dal Pozzo, Carlo Alberto, Deckert, Jutta, Loupakis, Fotios, Fassan, Matteo, Baffa, Raffaele

“…The recent advent of immunomodulatory therapies into the clinic has demanded the identification of innovative predictive biomarkers to identify patients most…”
Get full text

Evolution of HER2-low expression from primary to recurrent breast cancer by Miglietta, Federica, Griguolo, Gaia, Bottosso, Michele, Giarratano, Tommaso, Lo Mele, Marcello, Fassan, Matteo, Cacciatore, Matilde, Genovesi, Elisa, De Bartolo, Debora, Vernaci, Grazia, Amato, Ottavia, Conte, PierFranco, Guarneri, Valentina, Dieci, Maria Vittoria

“…About a half of HER2-negative breast cancer (BC) show HER2-low expression that can be targeted by new antibody-drug conjugates. The main aim of this study is…”
Get full text

Primary and secondary clarithromycin resistance in Helicobacter pylori and mathematical modeling of the role of macrolides by Kocsmár, Éva, Buzás, György Miklós, Szirtes, Ildikó, Kocsmár, Ildikó, Kramer, Zsófia, Szijártó, Attila, Fadgyas-Freyler, Petra, Szénás, Kató, Rugge, Massimo, Fassan, Matteo, Kiss, András, Schaff, Zsuzsa, Röst, Gergely, Lotz, Gábor

“…Clarithromycin is a macrolide antibiotic widely used for eradication of Helicobacter pylori infection, and thus resistance to this antibiotic is a major cause…”
Get full text

Gastritis staging in the endoscopic follow-up for the secondary prevention of gastric cancer: a 5-year prospective study of 1755 patients by Rugge, Massimo, Meggio, Alberto, Pravadelli, Cecilia, Barbareschi, Mattia, Fassan, Matteo, Gentilini, Maria, Zorzi, Manuel, Pretis, Giovanni De, Graham, David Y, Genta, Robert M

“…Operative link on gastritis assessment (OLGA) staging for gastritis ranks the risk for gastric cancer (GC) in progressive stages (0-IV). This prospective study…”
Get more information

A KRAS-responsive long non-coding RNA controls microRNA processing by Shi, Lei, Magee, Peter, Fassan, Matteo, Sahoo, Sudhakar, Leong, Hui Sun, Lee, Dave, Sellers, Robert, Brullé-Soumaré, Laura, Cairo, Stefano, Monteverde, Tiziana, Volinia, Stefano, Smith, Duncan D., Di Leva, Gianpiero, Galuppini, Francesca, Paliouras, Athanasios R., Zeng, Kang, O’Keefe, Raymond, Garofalo, Michela

“…Wild-type KRAS ( KRAS WT ) amplification has been shown to be a secondary means of KRAS activation in cancer and associated with poor survival. Nevertheless,…”
Get full text

OLGA Gastritis Staging for the Prediction of Gastric Cancer Risk: A Long-term Follow-up Study of 7436 Patients by Rugge, Massimo, Genta, Robert M, Fassan, Matteo, Valentini, Elisa, Coati, Irene, Guzzinati, Stefano, Savarino, Edoardo, Zorzi, Manuel, Farinati, Fabio, Malfertheiner, Peter

“…Gastritis OLGA-staging ranks the risk for gastric cancer (GC) in progressive stages (0-IV). This long-term follow-up study quantifies the GC risk associated…”
Get full text

Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations by Wardell, Christopher P., Fujita, Masashi, Yamada, Toru, Simbolo, Michele, Fassan, Matteo, Karlic, Rosa, Polak, Paz, Kim, Jaegil, Hatanaka, Yutaka, Maejima, Kazuhiro, Lawlor, Rita T., Nakanishi, Yoshitsugu, Mitsuhashi, Tomoko, Fujimoto, Akihiro, Furuta, Mayuko, Ruzzenente, Andrea, Conci, Simone, Oosawa, Ayako, Sasaki-Oku, Aya, Nakano, Kaoru, Tanaka, Hiroko, Yamamoto, Yujiro, Michiaki, Kubo, Kawakami, Yoshiiku, Aikata, Hiroshi, Ueno, Masaki, Hayami, Shinya, Gotoh, Kunihito, Ariizumi, Shun-ichi, Yamamoto, Masakazu, Yamaue, Hiroki, Chayama, Kazuaki, Miyano, Satoru, Getz, Gad, Scarpa, Aldo, Hirano, Satoshi, Nakamura, Toru, Nakagawa, Hidewaki

“…[Display omitted] •Biliary tract cancers are clinically and genetically heterogeneous.•32 significantly mutated genes were identified, some negatively…”
Get full text

AMPKα loss promotes KRAS-mediated lung tumorigenesis by La Montagna, Manuela, Shi, Lei, Magee, Peter, Sahoo, Sudhakar, Fassan, Matteo, Garofalo, Michela

“…AMP-activated protein kinase (AMPK) is a critical sensor of energy status that coordinates cell growth with energy balance. In non-small cell lung cancer…”
Get full text

A pH-sensitive stearoyl-PEG-poly(methacryloyl sulfadimethoxine)-decorated liposome system for protein delivery: An application for bladder cancer treatment by Vila-Caballer, Marian, Codolo, Gaia, Munari, Fabio, Malfanti, Alessio, Fassan, Matteo, Rugge, Massimo, Balasso, Anna, de Bernard, Marina, Salmaso, Stefano

“…Stealth pH-responsive liposomes for the delivery of therapeutic proteins to the bladder epithelium were prepared using methoxy-poly(ethylene…”
Get full text

Autoimmune gastritis:Pathologist’s viewpoint by Coati, Irene, Fassan, Matteo, Farinati, Fabio, Graham, David Y, Genta, Robert M, Rugge, Massimo

“…Western countries are seeing a constant decline in the incidence of Helicobacter pylori-associated gastritis, coupled with a rising epidemiological and…”
Get full text

Targeted therapies in metastatic gastric cancer: Current knowledge and future perspectives by Pellino, Antonio, Riello, Erika, Nappo, Floriana, Brignola, Stefano, Murgioni, Sabina, Djaballah, Selma Ahcene, Lonardi, Sara, Zagonel, Vittorina, Rugge, Massimo, Loupakis, Fotios, Fassan, Matteo

“…Gastric cancer (GC) represents a leading cause of cancer related morbidity and mortality worldwide accounting for more than 1 million of newly diagnosed cases…”
Get full text

Tumor Budding as a Risk Factor for Nodal Metastasis in Pt1 Colorectal Cancers: A Meta-Analysis by Cappellesso, Rocco, MD, Luchini, Claudio, MD, Veronese, Nicola, MD, Mele, Marcello Lo, MD, Rosa-Rizzotto, Erik, MD, Guido, Ennio, MD, De Lazzari, Franca, MD, Pilati, Pierluigi, MD, Farinati, Fabio, MD, Realdon, Stefano, MD, PhD, Solmi, Marco, MD, Fassan, Matteo, MD, PhD, Rugge, Massimo, MD,FACG

“…Summary Worldwide, colorectal cancer (CRC) screening programs have significantly increased the detection of sub-mucosal (pT1) adenocarcinoma. Completion…”
Get full text

DNA qualification workflow for next generation sequencing of histopathological samples by Simbolo, Michele, Gottardi, Marisa, Corbo, Vincenzo, Fassan, Matteo, Mafficini, Andrea, Malpeli, Giorgio, Lawlor, Rita T, Scarpa, Aldo

“…Histopathological samples are a treasure-trove of DNA for clinical research. However, the quality of DNA can vary depending on the source or extraction method…”
Get full text

Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation by Gasparini, Pierluigi, Lovat, Francesca, Fassan, Matteo, Casadei, Lucia, Cascione, Luciano, Jacob, Naduparambil K., Carasi, Stefania, Palmieri, Dario, Costinean, Stefan, Shapiro, Charles L., Huebner, Kay, Croce, Carlo M.

“…Cell survival after DNA damage relies on DNA repair, the abrogation of which causes genomic instability and development of cancer. However, defective DNA…”
Get full text

PIK3CA Mutations as a Molecular Target for Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer by Fusco, Nicola, Malapelle, Umberto, Fassan, Matteo, Marchiò, Caterina, Buglioni, Simonetta, Zupo, Simonetta, Criscitiello, Carmen, Vigneri, Paolo, Dei Tos, Angelo Paolo, Maiorano, Eugenio, Viale, Giuseppe

“…Despite the significant achievements in the diagnosis and treatment of metastatic breast cancer (MBC), this condition remains substantially an incurable…”
Get full text