Search Results - "Fass, D M"

Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder by Bavamian, S, Mellios, N, Lalonde, J, Fass, D M, Wang, J, Sheridan, S D, Madison, J M, Zhou, Fen, Rueckert, E H, Barker, D, Perlis, R H, Sur, M, Haggarty, S J

“…Bipolar disorder (BD) is a heritable neuropsychiatric disorder with largely unknown pathogenesis. Given their prominent role in brain function and disease, we…”
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Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers by Wagner, F F, Zhang, Y-L, Fass, D M, Joseph, N, Gale, J P, Weïwer, M, McCarren, P, Fisher, S L, Kaya, T, Zhao, W-N, Reis, S A, Hennig, K M, Thomas, M, Lemercier, B C, Lewis, M C, Guan, J S, Moyer, M P, Scolnick, E, Haggarty, S J, Tsai, L-H, Holson, E B

“…Aiming towards the development of novel nootropic therapeutics to address the cognitive impairment common to a range of brain disorders, we set out to develop…”
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Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1–PAK3 signaling in neuroplasticity by Kim, M J, Biag, J, Fass, D M, Lewis, M C, Zhang, Q, Fleishman, M, Gangwar, S P, Machius, M, Fromer, M, Purcell, S M, McCarroll, S A, Rudenko, G, Premont, R T, Scolnick, E M, Haggarty, S J

“…Although the pathogenesis of schizophrenia (SCZ) is proposed to involve alterations of neural circuits via synaptic dysfunction, the underlying molecular…”
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Noncoding RNAs connect genetic risk factors to the neurodevelopmental basis of bipolar disorder by Bavamian, S, Mellios, N, Lalonde, J, Fass, D M, Wang, J, Sheridan, S D, Madison, J M, Zhou, Fen, Rueckert, E H, Barker, D, Perlis, R H, Sur, M, Haggarty, S J

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Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities by Madison, J M, Zhou, F, Nigam, A, Hussain, A, Barker, D D, Nehme, R, van der Ven, K, Hsu, J, Wolf, P, Fleishman, M, O'Dushlaine, C, Rose, S, Chambert, K, Lau, F H, Ahfeldt, T, Rueckert, E H, Sheridan, S D, Fass, D M, Nemesh, J, Mullen, T E, Daheron, L, McCarroll, S, Sklar, P, Perlis, R H, Haggarty, S J

“…Bipolar disorder (BD) is a common neuropsychiatric disorder characterized by chronic recurrent episodes of depression and mania. Despite evidence for high…”
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Epigenetic mechanisms in mood disorders: Targeting neuroplasticity by Fass, D.M, Schroeder, F.A, Perlis, R.H, Haggarty, S.J

“…Graphical abstract Highlights ► Molecular mechanisms of mood disorders involving altered neuroplasticity. ► Epigenetic mechanisms play a critical role in the…”
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Phosphorylation of CBP Mediates Transcriptional Activation by Neural Activity and CaM Kinase IV by Impey, Soren, Fong, Amy L., Wang, Yanhong, Cardinaux, Jean-Rene, Fass, Daniel M., Obrietan, Karl, Wayman, Gary A., Storm, Daniel R., Soderling, Thomas R., Goodman, Richard H.

“…Activity-regulated transcription has been implicated in adaptive plasticity in the CNS. In many instances, this plasticity depends upon the transcription…”
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Deacetylase Activity Is Required for cAMP Activation of a Subset of CREB Target Genes by Fass, Daniel M., Butler, Jennifer E.F., Goodman, Richard H.

“…Many hormones activate transcription by raising the level of cAMP within cells. In one well studied pathway, cAMP induces protein kinase A to phosphorylate the…”
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Bay K 8644 reveals two components of L-type Ca2+ channel current in clonal rat pituitary cells by Fass, D M, Levitan, E S

“…Whole-cell L-type Ca2+ channel current was recorded in GH3 clonal rat pituitary cells using Ba2+ as a charge carrier. In the presence of the dihydropyridine…”
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Calcium and cAMP Signals Differentially Regulate cAMP-responsive Element-binding Protein Function via a Rap1-Extracellular Signal-regulated Kinase Pathway by Grewal, Savraj S., Fass, Daniel M., Yao, Hong, Ellig, Cindy L., Goodman, Richard H., Stork, Philip J.S.

“…Two major intracellular signals that regulate neuronal function are calcium and cAMP. In many cases, the actions of these two second messengers involve long…”
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Current, voltage and pharmacological substrates of a novel GABA receptor in the visual-vestibular system of Hermissenda by Rogers, R F, Fass, D M, Matzel, L D

“…In the marine mollusc, Hermissenda crassicornis, Type B photoreceptors exhibit an IPSP to both presynaptic hair cell stimulation and microapplication of…”
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GABA-mediated synaptic interaction between the visual and vestibular pathways of Hermissenda by Alkon, D L, Anderson, M J, Kuzirian, A J, Rogers, D F, Fass, D M, Collin, C, Nelson, T J, Kapetanovic, I M, Matzel, L D

“…The synaptic convergence of the eyes and the vestibular hair cells in the nudibranch mollusc Hermissenda has been shown previously to mediate the learning of…”
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Emergence of excitotoxicity in cultured forebrain neurons coincides with larger glutamate-stimulated [Ca(2+)](i) increases and NMDA receptor mRNA levels by Cheng, C, Fass, D M, Reynolds, I J

“…We examined several factors related to the increase in susceptibility to excitotoxicity that occurs in embryonic forebrain neurons over time in culture…”
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Recruitment of CREB Binding Protein Is Sufficient for CREB-Mediated Gene Activation by Cardinaux, Jean-Rene, Notis, John C., Zhang, Qinghong, Vo, Ngan, Craig, Johanna C., Fass, Daniel M., Brennan, Richard G., Goodman, Richard H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cooperative Mechanism of Transcriptional Activation by a Cyclic AMP-response Element Modulator α Mutant Containing a Motif for Constitutive Binding to CREB-binding Protein by Fass, Daniel M., Craig, Johanna C., Impey, Soren, Goodman, Richard H.

“…Cyclic AMP-response element modulator α (CREMα) is a transcription factor that is highly related to cAMP-response element-binding protein (CREB) but represses…”
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EPIGENETIC MECHANISMS IN MOOD DISORDERS: TARGETING NEUROPLASTICITY: Epigenetics in Brain Function by FASS, D. M, SCHROEDER, F. A, PERLIS, R. H, HAGGARTY, S. J

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Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancersElectronic supplementary information (ESI) available: Compound synthesis and characterization; 1HNMR spectra, HPLC or UPLC spectral traces; HDAC enzymatic assay protocol; IC50s for representative compounds for HDACs 1-9; full kinetic parameters for BRD4884 and BRD6688; progression and dissociation curves for BRD6688; pharmacokinetic graphs and parameters for representative compounds; kinetic selectivity profi by Wagner, F. F, Zhang, Y.-L, Fass, D. M, Joseph, N, Gale, J. P, Weïwer, M, McCarren, P, Fisher, S. L, Kaya, T, Zhao, W.-N, Reis, S. A, Hennig, K. M, Thomas, M, Lemercier, B. C, Lewis, M. C, Guan, J. S, Moyer, M. P, Scolnick, E, Haggarty, S. J, Tsai, L.-H, Holson, E. B

“…Aiming towards the development of novel nootropic therapeutics to address the cognitive impairment common to a range of brain disorders, we set out to develop…”
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Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers† †Electronic supplementary information (ESI) available: Compound synthesis and characterization; 1HNMR spectra, HPLC or UPLC spectral traces; HDAC enzymatic assay protocol; IC50s for representative compounds for HDACs 1–9; full kinetic parameters for BRD4884 and BRD6688; progression and dissociation curves for BRD6688; pharmacokinetic graphs and parameters for representative compounds; kinetic selectivity pr by Wagner, F. F., Zhang, Y.-L., Fass, D. M., Joseph, N., Gale, J. P., Weïwer, M., McCarren, P., Fisher, S. L., Kaya, T., Zhao, W.-N., Reis, S. A., Hennig, K. M., Thomas, M., Lemercier, B. C., Lewis, M. C., Guan, J. S., Moyer, M. P., Scolnick, E., Haggarty, S. J., Tsai, L.-H., Holson, E. B.

“…Kinetically selective inhibitors of HDAC2 enhanced learning and memory in a CK-p25 mouse model of neurodegeneration. Aiming towards the development of novel…”
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Preoperative Diagnostic Workup before Antireflux Surgery: An Evidence and Experience-Based Consensus of the Esophageal Diagnostic Advisory Panel by Jobe, Blair A., MD, FACS, Richter, Joel E., MD, Hoppo, Toshitaka, MD, PhD, Peters, Jeffrey H., MD, FACS, Bell, Reginald, MD, FACS, Dengler, William C., MD, FACS, DeVault, Kenneth, MD, Fass, Ronnie, MD, Gyawali, C. Prakash, MD, Kahrilas, Peter J., MD, Lacy, Brian E., MD, PhD, FACG, Pandolfino, John E., MD, Patti, Marco G., MD, FACS, Swanstrom, Lee L., MD, FACS, Kurian, Ashwin A., MD, Vela, Marcelo F., MD, Vaezi, Michael, MD, DeMeester, Tom R., MD, FACS

“…Background Gastroesophageal reflux disease (GERD) is a very prevalent disorder. Medical therapy improves symptoms in some but not all patients. Antireflux…”
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Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles by Wawer, Mathias J, Jaramillo, David E, Dančík, Vlado, Fass, Daniel M, Haggarty, Stephen J, Shamji, Alykhan F, Wagner, Bridget K, Schreiber, Stuart L, Clemons, Paul A

“…Understanding the structure-activity relationships (SARs) of small molecules is important for developing probes and novel therapeutic agents in chemical…”
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