Search Results - "Fasimoye, Rotimi"

Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins by Bond, Adam G, Craigon, Conner, Chan, Kwok-Ho, Testa, Andrea, Karapetsas, Athanasios, Fasimoye, Rotimi, Macartney, Thomas, Blow, J. Julian, Alessi, Dario R, Ciulli, Alessio

“…Small-molecule-induced protein depletion technologies, also called inducible degrons, allow degradation of genetically engineered target proteins within cells…”
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Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling by Brewer, Abigail, Zhao, Jin-Feng, Fasimoye, Rotimi, Shpiro, Natalia, Macartney, Thomas J., Wood, Nicola T., Wightman, Melanie, Alessi, Dario R., Sapkota, Gopal P.

“…TGF-β (transforming growth factor-β) signaling is involved in a myriad of cellular processes and its dysregulation has been implicated in many human diseases,…”
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The antiplasmodial activity of Anogeissus leiocarpus and its effect on oxidative stress and lipid profile in mice infected with Plasmodium bergheii by Akanbi, Olusegun Matthew, Omonkhua, Akhere A., Cyril-Olutayo, Christianah M., Fasimoye, Rotimi Yemi

“…Methanolic extracts of Anogeissus leiocarpus has been considered locally to have the same antimalarial activities as artemisinin derivatives. This work studied…”
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A nematode-specific ribonucleoprotein complex mediates interactions between the major nematode spliced leader snRNP and its target pre-mRNAs by Eijlers, Peter, Al-Khafaji, Mohammed, Soto-Martin, Eva, Fasimoye, Rotimi, Stead, David, Wenzel, Marius, Müller, Berndt, Pettitt, Jonathan

“…Spliced leader trans-splicing of pre-mRNAs is a critical step in the gene expression of many eukaryotes. How the spliced leader RNA and its target transcripts…”
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Golgi-IP, a tool for multimodal analysis of Golgi molecular content by Fasimoye, Rotimi, Dong, Wentao, Nirujogi, Raja S, Rawat, Eshaan S, Iguchi, Miharu, Nyame, Kwamina, Phung, Toan K, Bagnoli, Enrico, Prescott, Alan R, Alessi, Dario R, Abu-Remaileh, Monther

“…The Golgi is a membrane-bound organelle that is essential for protein and lipid biosynthesis. It represents a central trafficking hub that sorts proteins and…”
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A novel, essential trans -splicing protein connects the nematode SL1 snRNP to the CBC-ARS2 complex by Fasimoye, Rotimi Yemi, Spencer, Rosie Elizabeth Barker, Soto-Martin, Eva, Eijlers, Peter, Elmassoudi, Haitem, Brivio, Sarah, Mangana, Carolina, Sabele, Viktorija, Rechtorikova, Radoslava, Wenzel, Marius, Connolly, Bernadette, Pettitt, Jonathan, Müller, Berndt

“…Abstract Spliced leader trans-splicing is essential for gene expression in many eukaryotes. To elucidate the molecular mechanism of this process, we…”
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An in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assembly by Philippe, Lucas, Pandarakalam, George C, Fasimoye, Rotimi, Harrison, Neale, Connolly, Bernadette, Pettitt, Jonathan, Müller, Berndt

“…Spliced leader (SL) trans-splicing is a critical element of gene expression in a number of eukaryotic groups. This process is arguably best understood in…”
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Studies on the interaction mechanisms of Garcinia kolaviron constituents with selected diabetes and neurodegenerative disease targets by Ogunwa, Tomisin Happy, Fasimoye, Rotimi Yemi, Adeyelu, Tolulope Tosin

“…Emerging evidence has shown kolaviron, a Garcinia biflavonoid complex, as inhibitor of α-amylase, aldose reductase and acetylcholinesterase in vitro. Herein,…”
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Parkinson's VPS35D620N mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B by Pal, Prosenjit, Taylor, Matthew, Lam, Pui Yiu, Tonelli, Francesca, Hecht, Chloe A, Lis, Pawel, Nirujogi, Raja S, Phung, Toan K, Yeshaw, Wondwossen M, Jaimon, Ebsy, Fasimoye, Rotimi, Dickie, Emily A, Wightman, Melanie, Macartney, Thomas, Pfeffer, Suzanne R, Alessi, Dario R

“…We demonstrate that the Parkinson's VPS35[D620N] mutation alters the expression of ~220 lysosomal proteins and stimulates recruitment and phosphorylation of…”
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Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B by Pal, Prosenjit, Taylor, Matthew, Lam, Pui Yiu, Tonelli, Francesca, Hecht, Chloe A, Lis, Pawel, Nirujogi, Raja S, Phung, Toan K, Yeshaw, Wondwossen M, Jaimon, Ebsy, Fasimoye, Rotimi, Dickie, Emily A, Wightman, Melanie, Macartney, Thomas, Pfeffer, Suzanne R, Alessi, Dario R

“…We demonstrate that the Parkinson's VPS35[D620N] mutation alters the expression of ~220 lysosomal proteins and stimulates recruitment and phosphorylation of…”
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A characterisation of RNA-protein molecules necessary for nematode spliced leader trans-splicing by Fasimoye, Rotimi Yemi

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