Search Results - "Fash, David M"

Novel idebenone analogs block Shc’s access to insulin receptor to improve insulin sensitivity by Hui, ChunKiu, Tomilov, Alexey, Garcia, Chase, Jiang, XiaoSong, Fash, David M., Khdour, Omar M., Rosso, Cristian, Filippini, Giacomo, Prato, Maurizio, Graham, James, Hecht, Sidney, Havel, Peter, Cortopassi, Gino

“…[Display omitted] •Idebenone drug engagement of p52Shc protein regulates insulin sensitivity.•Analogs of idebenone engage p52Shc and insulin-sensitizer…”
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Englerin a selectively induces necrosis in human renal cancer cells by Sulzmaier, Florian J, Li, Zhenwu, Nakashige, Mika L, Fash, David M, Chain, William J, Ramos, Joe W

“…The number of renal cancers has increased over the last ten years and patient survival in advanced stages remains very poor. Therefore, new therapeutic…”
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Englerins: A Comprehensive Review by Wu, Zhenhua, Zhao, Senzhi, Fash, David M, Li, Zhenwu, Chain, William J, Beutler, John A

“…In the decade since the discovery of englerin A (1) and its potent activity in cancer models, this natural product and its analogues have been the subject of…”
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Synthesis of a stable and orally bioavailable englerin analogue by Fash, David M., Peer, Cody J., Li, Zhenwu, Talisman, Ian J., Hayavi, Sima, Sulzmaier, Florian J., Ramos, Joe W., Sourbier, Carole, Neckers, Leonard, Figg, W. Douglas, Beutler, John A., Chain, William J.

“…[Display omitted] Synthesis of analogues of englerin A with a reduced propensity for hydrolysis of the glycolate moiety led to a compound which possessed the…”
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Effects of alkyl side chain modification of coenzyme Q₁₀ on mitochondrial respiratory chain function and cytoprotection by Fash, David M, Khdour, Omar M, Sahdeo, Sunil J, Goldschmidt, Ruth, Jaruvangsanti, Jennifer, Dey, Sriloy, Arce, Pablo M, Collin, Valérie C, Cortopassi, Gino A, Hecht, Sidney M

“…The effect of the alkyl side chain length of coenzyme Q₁₀ on mitochondrial respiratory chain function has been investigated by the use of synthetic ubiquinone…”
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Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases by Goldschmidt, Ruth, Arce, Pablo M., Khdour, Omar M., Collin, Valérie C., Dey, Sriloy, Jaruvangsanti, Jennifer, Fash, David M., Hecht, Sidney M.

“…Two new aza analogues of the neuroprotective agent idebenone have been synthesized and characterized. Their antioxidant activity, and ability to augment ATP…”
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Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection by Arce, Pablo M., Goldschmidt, Ruth, Khdour, Omar M., Madathil, Manikandadas M., Jaruvangsanti, Jennifer, Dey, Sriloy, Fash, David M., Armstrong, Jeffrey S., Hecht, Sidney M.

“…Selected pyridinol analogues of the experimental neuroprotective drug idebenone have been synthesized and evaluated as antioxidants capable of preserving…”
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Effects of alkyl side chain modification of coenzyme Q 10 on mitochondrial respiratory chain function and cytoprotection by Fash, David M., Khdour, Omar M., Sahdeo, Sunil J., Goldschmidt, Ruth, Jaruvangsanti, Jennifer, Dey, Sriloy, Arce, Pablo M., Collin, Valérie C., Cortopassi, Gino A., Hecht, Sidney M.

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