Search Results - "Fasciglione, Giovanni Francesco"

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes by Sbardella, Diego, Fasciglione, Giovanni Francesco, Gioia, Magda, Ciaccio, Chiara, Tundo, Grazia Raffaella, Marini, Stefano, Coletta, Massimo

“…Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by…”
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Multi-Anticancer Activities of Phytoestrogens in Human Osteosarcoma by Cimmino, Alessio, Fasciglione, Giovanni Francesco, Gioia, Magda, Marini, Stefano, Ciaccio, Chiara

“…Phytoestrogens are plant-derived bioactive compounds with estrogen-like properties. Their potential health benefits, especially in cancer prevention and…”
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Membrane Cholesterol Modulates LOX-1 Shedding in Endothelial Cells by Gioia, Magda, Vindigni, Giulia, Testa, Barbara, Raniolo, Sofia, Fasciglione, Giovanni Francesco, Coletta, Massimiliano, Biocca, Silvia

“…The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor responsible for ox-LDL recognition, binding and internalization,…”
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Gelatinolytic activity in gingival crevicular fluid and saliva of growing patients with Marfan syndrome: a case-control study by Laganà, Giuseppina, Fasciglione, Giovanni Francesco, Biondi, Andrea, Coletta, Massimiliano, Ruvolo, Giovanni, Cozza, Paola

“…Aim of the study was to evaluate the gelatinolytic activity in the saliva and gingival crevicular fluid from a sample group of subjects with Marfan syndrome…”
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A correlation between knee cartilage degradation observed by arthroscopy and synovial proteinases activities by Marini, Stefano, Francesco Fasciglione, Giovanni, Monteleone, Giovanni, Maiotti, Marco, Tarantino, Umberto, Coletta, Massimiliano

“…A novel study has been carried out to characterize the amount and activity levels of metalloproteinases (i.e., MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13)…”
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The enzymatic processing of α-dystroglycan by MMP-2 is controlled by two anchoring sites distinct from the active site by Gioia, Magda, Fasciglione, Giovanni Francesco, Sbardella, Diego, Sciandra, Francesca, Casella, MariaLuisa, Camerini, Serena, Crescenzi, Marco, Gori, Alessandro, Tarantino, Umberto, Cozza, Paola, Brancaccio, Andrea, Coletta, Massimo, Bozzi, Manuela

“…Dystroglycan (DG) is a membrane receptor, belonging to the dystrophin-glycoprotein complex (DGC) and formed by two subunits, α-dystroglycan (α-DG) and…”
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Effects of Extracellular Osteoanabolic Agents on the Endogenous Response of Osteoblastic Cells by Alloisio, Giulia, Ciaccio, Chiara, Fasciglione, Giovanni Francesco, Tarantino, Umberto, Marini, Stefano, Coletta, Massimo, Gioia, Magda

“…The complex multidimensional skeletal organization can adapt its structure in accordance with external contexts, demonstrating excellent self-renewal capacity…”
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Modulation of the proteolytic activity of matrix metalloproteinase-2 (gelatinase A) on fibrinogen by Monaco, Susanna, Gioia, Magda, Rodriguez, Janet, Fasciglione, Giovanni Francesco, Di Pierro, Donato, Lupidi, Giulio, Krippahl, Ludwig, Marini, Stefano, Coletta, Massimo

“…The proteolytic processing of bovine fibrinogen by MMP-2 (gelatinase A), which brings about the formation of a product unable to form fibrin clots, has been…”
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Role of metalloproteinases in tendon pathophysiology by Sbardella, Diego, Tundo, Grazia R, Fasciglione, Giovanni Francesco, Gioia, Magda, Bisicchia, Salvatore, Gasbarra, Elena, Ippolito, Ernesto, Tarantino, Umberto, Coletta, Massimo, Marini, Stefano

“…Tendons play a crucial role in musculoskeletal functioning because they physically connect bones and muscles making the movement of articular joints possible…”
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Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches by Gioia, Magda, Ciaccio, Chiara, Calligari, Paolo, De Simone, Giovanna, Sbardella, Diego, Tundo, Grazia, Fasciglione, Giovanni Francesco, Di Masi, Alessandra, Di Pierro, Donato, Bocedi, Alessio, Ascenzi, Paolo, Coletta, Massimo

“…[Display omitted] In the Fall of 2019 a sudden and dramatic outbreak of a pulmonary disease (Coronavirus Disease COVID-19), due to a new Coronavirus strain…”
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Effect of Axial Coordination on the Kinetics of Assembly and Folding of the Two Halves of Horse Heart Cytochrome c by De Sanctis, Giampiero, Ciaccio, Chiara, Fasciglione, Giovanni Francesco, Fiorucci, Laura, Gioia, Magda, Sinibaldi, Federica, Marini, Stefano, Santucci, Roberto, Coletta, Massimo

“…The kinetics of the assembly of two complementary fragments of oxidized horse heart cytochrome c (cyt c), namely the heme-containing fragment-(1–56) and the…”
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Modulation of the Catalytic Activity of Neutrophil Collagenase MMP-8 on Bovine Collagen I by Gioia, Magda, Fasciglione, Giovanni Francesco, Marini, Stefano, D'Alessio, Silvana, De Sanctis, Giampiero, Diekmann, Oliver, Pieper, Michael, Politi, Vincenzo, Tschesche, Harald, Coletta, Massimo

“…The cleavage of bovine collagen I by neutrophil collagenase MMP-8 has been followed at pH 7.4, 37 °C. The behavior of the whole enzyme molecule (whMMP-8),…”
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Cleavage of Bovine Collagen I by Neutrophil Collagenase MMP-8 by Marini, Stefano, Fasciglione, Giovanni Francesco, de Sanctis, Giampiero, D'Alessio, Silvana, Politi, Vincenzo, Coletta, Massimo

“…The enzymatic processing of bovine collagen I by neutrophil collagenase (MMP-8) has been monitored at 37 °C, envisaging the occurrence of multiple intermediate…”
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The enzymatic processing of [alpha]-dystroglycan by MMP-2 is controlled by two anchoring sites distinct from the active site by Gioia, Magda, Fasciglione, Giovanni Francesco, Sbardella, Diego, Sciandra, Francesca, Casella, MariaLuisa, Camerini, Serena, Crescenzi, Marco, Gori, Alessandro, Tarantino, Umberto, Cozza, Paola, Brancaccio, Andrea, Coletta, Massimo, Bozzi, Manuela

“…Dystroglycan (DG) is a membrane receptor, belonging to the dystrophin-glycoprotein complex (DGC) and formed by two subunits, [alpha]-dystroglycan ([alpha]-DG)…”
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Characterization of the Mechanisms by which Gelatinase A, Neutrophil Collagenase, and Membrane-Type Metalloproteinase MMP-14 Recognize Collagen I and Enzymatically Process the Two α-Chains by Gioia, Magda, Monaco, Susanna, Fasciglione, Giovanni Francesco, Coletti, Anna, Modesti, Andrea, Marini, Stefano, Coletta, Massimo

“…The turnover of native collagen has been ascribed to different members of the matrix metalloproteinase (MMP) family. Here, the mechanisms by which neutrophil…”
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Kinetic Investigation of Porphyrin Interaction with Chiral Templates Reveals Unexpected Features of the Induction and Self-Propagation Mechanism of Chiral Memory by Lauceri, Rosaria, Fasciglione, Giovanni Francesco, D’Urso, Alessandro, Marini, Stefano, Purrello, Roberto, Coletta, Massimiliano

“…Kinetics of the porphyrin aggregation leading to a chiral memory system shows a remarkable “catalytic” effect of the noncovalent templates explaining their…”
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pH dependence of the enzymatic processing of collagen I by MMP-1 (fibroblast collagenase), MMP-2 (gelatinase A), and MMP-14 ectodomain by Gioia, Magda, Fasciglione, Giovanni Francesco, Monaco, Susanna, Iundusi, Riccardo, Sbardella, Diego, Marini, Stefano, Tarantino, Umberto, Coletta, Massimo

“…The proteolytic processing of collagen I by three matrix metalloproteinases (MMPs), a collagenase (MMP-1), a gelatinase (MMP-2), and the ectodomain of a…”
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Structural bases for substrate and inhibitor recognition by matrix metalloproteinases by Aureli, Loretta, Gioia, Magda, Cerbara, Ilaria, Monaco, Susanna, Fasciglione, Giovanni Francesco, Marini, Stefano, Ascenzi, Paolo, Topai, Alessandra, Coletta, Massimo

“…Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases which are involved in the proteolytic processing of several components of the…”
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The collagenolytic action of MMP-1 is regulated by the interaction between the catalytic domain and the hinge region by Fasciglione, Giovanni Francesco, Gioia, Magda, Tsukada, Hiroki, Liang, Jian, Iundusi, Riccardo, Tarantino, Umberto, Coletta, Massimo, Pourmotabbed, Tayebeh, Marini, Stefano

“…The role of the hinge region in the unwinding and cleavage of type I collagen by interstitial collagenase (MMP-1) has been studied at 37 °C and pH 7.3. The…”
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Enzyme catalysis: the case of the prostate-specific antigen by Gioia, Magda, Tomao, Luigi, Sbardella, Diego, Ciaccio, Chiara, Tundo, Grazia Raffaella, Di Masi, Alessandra, Fasciglione, Giovanni Francesco, Marini, Stefano, Cozza, Paola, Ascenzi, Paolo, Coletta, Massimo

“…Proteases are a class of enzymes that lower the activation energy for the cleavage of the peptide bonds by polarizing the carbonyl group. The catalytic…”
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