Search Results - "Fasano, Alessio"

Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer by Fasano, Alessio

“…The primary functions of the gastrointestinal tract have traditionally been perceived to be limited to the digestion and absorption of nutrients and to…”
Get full text

Zonulin, regulation of tight junctions, and autoimmune diseases by Fasano, Alessio

“…Recent studies indicate that besides digestion and absorption of nutrients and water and electrolytes homeostasis, another key function of the intestine is to…”
Get full text

All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases [version 1; peer review: 3 approved] by Fasano, Alessio

“…Improved hygiene leading to reduced exposure to microorganisms has been implicated as one possible cause for the recent "epidemic" of chronic inflammatory…”
Get full text

Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases by Sturgeon, Craig, Fasano, Alessio

“…Beside digesting nutrients and absorbing solutes and electrolytes, the intestinal epithelium with its barrier function is in charge of a tightly controlled…”
Get full text

Celiac disease: a comprehensive current review by Caio, Giacomo, Volta, Umberto, Sapone, Anna, Leffler, Daniel A, De Giorgio, Roberto, Catassi, Carlo, Fasano, Alessio

“…Celiac disease remains a challenging condition because of a steady increase in knowledge tackling its pathophysiology, diagnosis, management, and possible…”
Get full text

Celiac Disease and the Microbiome by Valitutti, Francesco, Cucchiara, Salvatore, Fasano, Alessio

“…Growing evidence supports the hypothesis that changes in both the composition and function of the intestinal microbiome are associated with a number of chronic…”
Get full text

Clinical presentation of celiac disease in the pediatric population by Fasano, Alessio

“…Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten-containing grains (including wheat, rye, and barley) in genetically…”
Get full text

Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model by Sturgeon, Craig, Lan, Jinggang, Fasano, Alessio

“…Increased small intestinal permeability (IP) has been proposed to be an integral element, along with genetic makeup and environmental triggers, in the…”
Get full text

Chronic inflammation in the etiology of disease across the life span by Furman, David, Campisi, Judith, Verdin, Eric, Carrera-Bastos, Pedro, Targ, Sasha, Franceschi, Claudio, Ferrucci, Luigi, Gilroy, Derek W., Fasano, Alessio, Miller, Gary W., Miller, Andrew H., Mantovani, Alberto, Weyand, Cornelia M., Barzilai, Nir, Goronzy, Jorg J., Rando, Thomas A., Effros, Rita B., Lucia, Alejandro, Kleinstreuer, Nicole, Slavich, George M.

“…Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain…”
Get full text

Spectrum of gluten-related disorders: consensus on new nomenclature and classification by Sapone, Anna, Bai, Julio C, Ciacci, Carolina, Dolinsek, Jernej, Green, Peter H R, Hadjivassiliou, Marios, Kaukinen, Katri, Rostami, Kamran, Sanders, David S, Schumann, Michael, Ullrich, Reiner, Villalta, Danilo, Volta, Umberto, Catassi, Carlo, Fasano, Alessio

“…A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10…”
Get full text

Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease by Freire, Rachel, Ingano, Laura, Serena, Gloria, Cetinbas, Murat, Anselmo, Anthony, Sapone, Anna, Sadreyev, Ruslan I., Fasano, Alessio, Senger, Stefania

“…Celiac disease (CD) is an immune-mediated disorder triggered by gluten exposure. The contribution of the adaptive immune response to CD pathogenesis has been…”
Get full text

The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children by Porritt, Rebecca A, Binek, Aleksandra, Paschold, Lisa, Rivas, Magali Noval, McArdle, Angela, Yonker, Lael M, Alter, Galit, Chandnani, Harsha K, Lopez, Merrick, Fasano, Alessio, Van Eyk, Jennifer E, Binder, Mascha, Arditi, Moshe

“…Multisystem inflammatory syndrome in children (MIS-C) manifests as a severe and uncontrolled inflammatory response with multiorgan involvement, occurring weeks…”
Get full text

Celiac Disease Diagnosis: Simple Rules Are Better Than Complicated Algorithms by Catassi, Carlo, MD, MPH, Fasano, Alessio, MD

“…Abstract Celiac disease is the only treatable autoimmune disease, provided that a correct diagnosis is achieved and a strict, lifelong gluten-free diet is…”
Get full text

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder by Needham, Brittany D., Adame, Mark D., Serena, Gloria, Rose, Destanie R., Preston, Gregory M., Conrad, Mary C., Campbell, A. Stewart, Donabedian, David H., Fasano, Alessio, Ashwood, Paul, Mazmanian, Sarkis K.

“…Autism spectrum disorder (ASD) is a neurodevelopmental condition with hallmark behavioral manifestations including impaired social communication and restricted…”
Get full text

Pediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Clinical Presentation, Infectivity, and Immune Responses by Yonker, Lael M., Neilan, Anne M., Bartsch, Yannic, Patel, Ankit B., Regan, James, Arya, Puneeta, Gootkind, Elizabeth, Park, Grace, Hardcastle, Margot, St. John, Anita, Appleman, Lori, Chiu, Michelle L., Fialkowski, Allison, De la Flor, Denis, Lima, Rosiane, Bordt, Evan A., Yockey, Laura J., D'Avino, Paolo, Fischinger, Stephanie, Shui, Jessica E., Lerou, Paul H., Bonventre, Joseph V., Yu, Xu G., Ryan, Edward T., Bassett, Ingrid V., Irimia, Daniel, Edlow, Andrea G., Alter, Galit, Li, Jonathan Z., Fasano, Alessio

“…As schools plan for re-opening, understanding the potential role children play in the coronavirus infectious disease 2019 (COVID-19) pandemic and the factors…”
Get full text

Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study by Kang, Dae-Wook, Adams, James B, Gregory, Ann C, Borody, Thomas, Chittick, Lauren, Fasano, Alessio, Khoruts, Alexander, Geis, Elizabeth, Maldonado, Juan, McDonough-Means, Sharon, Pollard, Elena L, Roux, Simon, Sadowsky, Michael J, Lipson, Karen Schwarzberg, Sullivan, Matthew B, Caporaso, J Gregory, Krajmalnik-Brown, Rosa

“…Autism spectrum disorders (ASD) are complex neurobiological disorders that impair social interactions and communication and lead to restricted, repetitive, and…”
Get full text

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4 by Venkatesh, Madhukumar, Mukherjee, Subhajit, Wang, Hongwei, Li, Hao, Sun, Katherine, Benechet, Alexandre P., Qiu, Zhijuan, Maher, Leigh, Redinbo, Matthew R., Phillips, Robert S., Fleet, James C., Kortagere, Sandhya, Mukherjee, Paromita, Fasano, Alessio, Le Ven, Jessica, Nicholson, Jeremy K., Dumas, Marc E., Khanna, Kamal M., Mani, Sridhar

“…Intestinal microbial metabolites are conjectured to affect mucosal integrity through an incompletely characterized mechanism. Here we showed that…”
Get full text

Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders by Fiorentino, Maria, Sapone, Anna, Senger, Stefania, Camhi, Stephanie S, Kadzielski, Sarah M, Buie, Timothy M, Kelly, Deanna L, Cascella, Nicola, Fasano, Alessio

“…Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene-environment interactions. There are no definitive…”
Get full text

Humoral signatures of protective and pathological SARS-CoV-2 infection in children by Bartsch, Yannic C., Wang, Chuangqi, Zohar, Tomer, Fischinger, Stephanie, Atyeo, Caroline, Burke, John S., Kang, Jaewon, Edlow, Andrea G., Fasano, Alessio, Baden, Lindsey R., Nilles, Eric J., Woolley, Ann E., Karlson, Elizabeth W., Hopke, Alex R., Irimia, Daniel, Fischer, Eric S., Ryan, Edward T., Charles, Richelle C., Julg, Boris D., Lauffenburger, Douglas A., Yonker, Lael M., Alter, Galit

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread relentlessly, associated with a high frequency of respiratory…”
Get full text

Gluten and Functional Abdominal Pain Disorders in Children by Llanos-Chea, Alejandro, Fasano, Alessio

“…In children, functional gastrointestinal disorders (FGIDs) are common at all ages. Consumption of certain foods, particularly gluten, is frequently associated…”
Get full text