Search Results - "Farwell, Michael D"

PET/CT imaging in cancer: Current applications and future directions by Farwell, Michael D., Pryma, Daniel A., Mankoff, David A.

“…Positron emission tomography (PET) is a radiotracer imaging method that yields quantitative images of regional in vivo biology and biochemistry. PET, now used…”
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Development of Companion Diagnostics by Mankoff, David A., MD, PhD, Edmonds, Christine E., MD, Farwell, Michael D., MD, Pryma, Daniel A., MD

“…The goal of individualized and targeted treatment and precision medicine requires the assessment of potential therapeutic targets to direct treatment…”
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In vivo visualization of PARP inhibitor pharmacodynamics by McDonald, Elizabeth S, Pantel, Austin R, Shah, Payal D, Farwell, Michael D, Clark, Amy S, Doot, Robert K, Pryma, Daniel A, Carlin, Sean D

“…BACKGROUND[18F]FluorThanatrace ([18F]FTT) is a radiolabeled poly (adenosine diphosphate-ribose) polymerase inhibitor (PARPi) that enables noninvasive…”
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Imaging P-glycoprotein function in rats using [11C]-N-desmethyl-loperamide by Farwell, Michael D., Chong, Derek J., Iida, Yasuhiko, Bae, Sung A., Easwaramoorthy, Balu, Ichise, Masanori

“…Objective One mechanism that may be responsible for drug resistance in epilepsy is the upregulation of P-glycoprotein (P-gp), a drug efflux pump, at the…”
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A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma by Huang, Alexander C., Orlowski, Robert J., Xu, Xiaowei, Mick, Rosemarie, George, Sangeeth M., Yan, Patrick K., Manne, Sasikanth, Kraya, Adam A., Wubbenhorst, Bradley, Dorfman, Liza, D’Andrea, Kurt, Wenz, Brandon M., Liu, Shujing, Chilukuri, Lakshmi, Kozlov, Andrew, Carberry, Mary, Giles, Lydia, Kier, Melanie W., Quagliarello, Felix, McGettigan, Suzanne, Kreider, Kristin, Annamalai, Lakshmanan, Zhao, Qing, Mogg, Robin, Xu, Wei, Blumenschein, Wendy M., Yearley, Jennifer H., Linette, Gerald P., Amaravadi, Ravi K., Schuchter, Lynn M., Herati, Ramin S., Bengsch, Bertram, Nathanson, Katherine L., Farwell, Michael D., Karakousis, Giorgos C., Wherry, E. John, Mitchell, Tara C.

“…Immunologic responses to anti-PD-1 therapy in melanoma patients occur rapidly with pharmacodynamic T cell responses detectable in blood by 3 weeks. It is…”
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Immune PET Imaging by Iyalomhe, Osigbemhe, Farwell, Michael D.

“…Fluorodeoxyglucose (FDG) PET/CT is sensitive to metabolic, immune-related, and structural changes that can occur in tumors in cancer immunotherapy. Unique…”
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CD8-Targeted PET Imaging of Tumor-Infiltrating T Cells in Patients with Cancer: A Phase I First-in-Humans Study of 89Zr-Df-IAB22M2C, a Radiolabeled Anti-CD8 Minibody by Farwell, Michael D, Gamache, Raymond F, Babazada, Hasan, Hellmann, Matthew D, Harding, James J, Korn, Ron, Mascioni, Alessandro, Le, William, Wilson, Ian, Gordon, Michael S, Wu, Anna M, Ulaner, Gary A, Wolchok, Jedd D, Postow, Michael A, Pandit-Taskar, Neeta

“…There is a need for in vivo diagnostic imaging probes that can noninvasively measure tumor-infiltrating CD8+ leukocytes. Such imaging probes could be used to…”
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Positron Emission Tomography by Lameka, Katherine, Farwell, Michael D, Ichise, Masanori

“…Positron emission tomography (PET) is a minimally invasive imaging procedure with a wide range of clinical and research applications. PET allows for the…”
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Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene by Sellmyer, Mark A., Richman, Sarah A., Lohith, Katheryn, Hou, Catherine, Weng, Chi-Chang, Mach, Robert H., O’Connor, Roddy S., Milone, Michael C., Farwell, Michael D.

“…Cell-based therapeutics have considerable promise across diverse medical specialties; however, reliable human imaging of the distribution and trafficking of…”
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A PET imaging agent for evaluating PARP-1 expression in ovarian cancer by Makvandi, Mehran, Pantel, Austin, Schwartz, Lauren, Schubert, Erin, Xu, Kuiying, Hsieh, Chia-Ju, Hou, Catherine, Kim, Hyoung, Weng, Chi-Chang, Winters, Harrison, Doot, Robert, Farwell, Michael D, Pryma, Daniel A, Greenberg, Roger A, Mankoff, David A, Simpkins, Fiona, Mach, Robert H, Lin, Lilie L

“…Poly(ADP-ribose) polymerase (PARP) inhibitors are effective in a broad population of patients with ovarian cancer; however, resistance caused by low enzyme…”
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Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74 by Lee, Iris K, Noguera-Ortega, Estela, Xiao, Zebin, Todd, Leslie, Scholler, John, Song, Decheng, Liousia, Maria, Lohith, Katheryn, Xu, Kexiang, Edwards, Kimberly J, Farwell, Michael D, June, Carl H, Albelda, Steven M, Puré, Ellen, Sellmyer, Mark A

“…Despite the success of chimeric antigen receptor (CAR) T-cell therapy against hematologic malignancies, successful targeting of solid tumors with CAR T cells…”
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Artificial intelligence in immunotherapy PET/SPECT imaging by McGale, Jeremy P., Chen, Delphine L., Trebeschi, Stefano, Farwell, Michael D., Wu, Anna M., Cutler, Cathy S., Schwartz, Lawrence H., Dercle, Laurent

“…Objective Immunotherapy has dramatically altered the therapeutic landscape for oncology, but more research is needed to identify patients who are likely to…”
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A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours by Maity, Amit, Mick, Rosemarie, Huang, Alexander C., George, Sangeeth M., Farwell, Michael D., Lukens, John N., Berman, Abigail T., Mitchell, Tara C., Bauml, Josh, Schuchter, Lynn M., O’Hara, Mark, Lin, Lilie L., Demichele, Angela, Christodouleas, John P., Haas, Naomi B., Patsch, Dana M., Hahn, Stephen M., Minn, Andy J., Wherry, E. John, Vonderheide, Robert H.

“…Background We conducted a phase I trial evaluating pembrolizumab+hypofractionated radiotherapy (HFRT) for patients with metastatic cancers. Methods There were…”
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Analysis of Routine Computed Tomographic Scans With Radiomics and Machine Learning: One Step Closer to Clinical Practice by Farwell, Michael D, Mankoff, David A

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Incidental Orbital Neuroendocrine Metastases on 111In-OctreoScan and MRI by Chen, Yin Jie, Farwell, Michael D

“…ABSTRACTNeuroendocrine tumors have a propensity to metastasize, but rarely to the orbits. A 69-year-old woman with history of neuroendocrine tumor of…”
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FDG PET/CT Imaging 1 Week after a Single Dose of Pembrolizumab Predicts Treatment Response in Patients with Advanced Melanoma by Anderson, Thomas M, Chang, Bryan H, Huang, Alexander C, Xu, Xiaowei, Yoon, Daniel, Shang, Catherine G, Mick, Rosemarie, Schubert, Erin, McGettigan, Suzanne, Kreider, Kristin, Xu, Wei, Wherry, E John, Schuchter, Lynn M, Amaravadi, Ravi K, Mitchell, Tara C, Farwell, Michael D

“…Immunologic response to anti-programmed cell death protein 1 (PD-1) therapy can occur rapidly with T-cell responses detectable in as little as one week. Given…”
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Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted 18 F-Fluorthanatrace PET in Breast Cancer by Young, Anthony J, Pantel, Austin R, Kiani, Mahsa, Doot, Robert K, Bagheri, Sina, Pryma, Daniel A, Farwell, Michael D, Li, Shihong, Lee, Hsiaoju, Schubert, Erin K, Secreto, Anthony, Zuckerman, Samantha P, Nayak, Anupma, Choi, Hoon, Carlin, Sean, DeMichele, Angela, Mankoff, David A, Zhou, Rong, Mach, Robert H, McDonald, Elizabeth S

“…The poly(adenosine diphosphate-ribose) polymerase inhibitors (PARPi) have demonstrated efficacy in ovarian, breast, and prostate cancers, but current…”
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Early positron emission tomography/computed tomography as a predictor of response after CTL019 chimeric antigen receptor –T-cell therapy in B-cell non-Hodgkin lymphomas by Shah, Nirav N, Nagle, Sarah J, Torigian, Drew A, Farwell, Michael D, Hwang, Wei-Ting, Frey, Noelle, Nasta, Sunita D, Landsburg, Daniel, Mato, Anthony, June, Carl H, Schuster, Stephen J, Porter, David L, Svoboda, Jakub

“…Abstract Molecular imaging with18 F-Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is an established modality for response…”
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Making Molecular Imaging a Clinical Tool for Precision Oncology: A Review by Mankoff, David A, Farwell, Michael D, Clark, Amy S, Pryma, Daniel A

“…Individualized cancer treatment, tailored to a particular patient and the tumor's biological features (precision oncology), requires a detailed knowledge of…”
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Using CD69 PET Imaging to Monitor Immunotherapy-Induced Immune Activation by Edwards, Kimberly J, Chang, Bryan, Babazada, Hasan, Lohith, Katheryn, Park, Daniel H, Farwell, Michael D, Sellmyer, Mark A

“…Immune checkpoint inhibitors (ICI) have been effective in treating a subset of refractory solid tumors, but only a small percentage of treated patients benefit…”
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