Search Results - "Farwell, C."

Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo by McIntosh, John A., Coelho, Pedro S., Farwell, Christopher C., Wang, Z. Jane, Lewis, Jared C., Brown, Tristan R., Arnold, Frances H.

“…Nitrogen activation: Though P450 enzymes are masters of oxygen activation and insertion into CH bonds, their ability to use nitrogen for the same purpose has…”
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Expanding P450 catalytic reaction space through evolution and engineering by McIntosh, John A, Farwell, Christopher C, Arnold, Frances H

“…•Discovering enzymes for new reactions is important but challenging.•Cytochrome P450 enzymes catalyze many different chemical reactions in nature.•P450s can be…”
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Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran by Wang, Z. Jane, Renata, Hans, Peck, Nicole E., Farwell, Christopher C., Coelho, Pedro S., Arnold, Frances H.

“…Engineering enzymes capable of modes of activation unprecedented in nature will increase the range of industrially important molecules that can be synthesized…”
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Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy by Prier, Christopher K., Hyster, Todd K., Farwell, Christopher C., Huang, Audrey, Arnold, Frances H.

“…Sigmatropic rearrangements, while rare in biology, offer opportunities for the efficient and selective synthesis of complex chemical motifs. A “P411”…”
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Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer by Farwell, Christopher C, McIntosh, John A, Hyster, Todd K, Wang, Z. Jane, Arnold, Frances H

“…Engineering enzymes with novel reaction modes promises to expand the applications of biocatalysis in chemical synthesis and will enhance our understanding of…”
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High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy by Tran, Nhi L, Senko, Skerdi, Lucier, Kyle W, Farwell, Ashlyn C, Silva, Sabrina M, Dip, Phat V, Poweleit, Nicole, Scapin, Giovanna, Catalano, Claudio

“…Membrane proteins constitute about 20% of the human proteome and play crucial roles in cellular functions. However, a complete understanding of their structure…”
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Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450 by Farwell, Christopher C, Zhang, Ruijie K, McIntosh, John A, Hyster, Todd K, Arnold, Frances H

“…One of the greatest challenges in protein design is creating new enzymes, something evolution does all the time, starting from existing ones. Borrowing from…”
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Quantifying energy intake in Pacific bluefin tuna (Thunnus orientalis) using the heat increment of feeding by Whitlock, R E, Walli, A, Cermeño, P, Rodriguez, L E, Farwell, C, Block, B A

“…Using implanted archival tags, we examined the effects of meal caloric value, food type (sardine or squid) and ambient temperature on the magnitude and…”
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Migratory Movements, Depth Preferences, and Thermal Biology of Atlantic Bluefin Tuna by Block, Barbara A., Dewar, Heidi, Blackwell, Susanna B., Williams, Thomas D., Prince, Eric D., Farwell, Charles J., Boustany, Andre, Steven L. H. Teo, Seitz, Andrew, Walli, Andreas, Fudge, Douglas

“…The deployment of electronic data storage tags that are surgically implanted or satellite-linked provides marine researchers with new ways to examine the…”
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Postprandial metabolism of Pacific bluefin tuna (Thunnus orientalis) by Clark, T D, Brandt, W T, Nogueira, J, Rodriguez, L E, Price, M, Farwell, C J, Block, B A

“…Specific dynamic action (SDA) is defined as the energy expended during ingestion, digestion, absorption and assimilation of a meal. This study presents the…”
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Heart rate responses to temperature in free-swimming Pacific bluefin tuna (Thunnus orientalis) by Clark, T D, Farwell, C J, Rodriguez, L E, Brandt, W T, Block, B A

“…The bluefin tuna heart remains at ambient water temperature (Ta) but must supply blood to warm regions of the body served by countercurrent vascular heat…”
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Satellite tracking the world's largest jelly predator, the ocean sunfish, Mola mola, in the Western Pacific by Dewar, H., Thys, T., Teo, S.L.H., Farwell, C., O'Sullivan, J., Tobayama, T., Soichi, M., Nakatsubo, T., Kondo, Y., Okada, Y., Lindsay, D.J., Hays, G.C., Walli, A., Weng, K., Streelman, J.T., Karl, S.A.

“…Twelve ocean sunfish, Mola mola, were tagged with pop-up satellite archival tags off the coast of Kamogawa, Japan during the spring of 2001 and 2003–2006…”
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Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination by Hyster, Todd K, Farwell, Christopher C, Buller, Andrew R, McIntosh, John A, Arnold, Frances H

“…We recently demonstrated that variants of cytochrome P450BM3 (CYP102A1) catalyze the insertion of nitrogen species into benzylic C–H bonds to form new C–N…”
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Improved Cyclopropanation Activity of Histidine-Ligated CytochromeP450 Enables the Enantioselective Formal Synthesis of Levomilnacipran by Wang, Z Jane, Renata, Hans, Peck, Nicole E, Farwell, Christopher C, Coelho, Pedro S, Arnold, Frances H

“…Engineering enzymes capable of modes of activation unprecedented in nature will increase the range of industrially important molecules that can be synthesized…”
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The CryoEM structure of human serum albumin in complex with ligands by Catalano, Claudio, Lucier, Kyle W., To, Dennis, Senko, Skerdi, Tran, Nhi L., Farwell, Ashlyn C., Silva, Sabrina M., Dip, Phat V., Poweleit, Nicole, Scapin, Giovanna

“…[Display omitted] •Human serum albumin has a crucial role in regulating biological system.•Understanding HSA-ligand interactions is key for DMPK optimization…”
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Depth and muscle temperature of Pacific bluefin tuna examined with acoustic and pop-up satellite archival tags by MARCINEK, David J, BLACKWELL, Susanna B, DEWAR, Heidi, FREUND, Ellen V, FARWELL, Charles, DAU, Daniel, SEITZ, Andrew C, BLOCK, Barbara A

“…Six Pacific bluefin tuna were tracked with ultrasonic telemetry and two with pop-up satellite archival tags (PSATs) in the eastern Pacific Ocean in 1997, 1998,…”
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Environmental preferences of yellowfin tuna (Thunnus albacares) at the northern extent of its range by BLOCK, B. A, KEEN, J. E, CASTILLO, B, DEWAR, H, FREUND, E. V, MARCINEK, D. J, BRILL, R. W, FARWELL, C

“…We used acoustic telemetry to examine the small-scale movement patterns of yellowfin tuna (Thunnus albacares) in the California Bight at the northern extent of…”
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High-Quality Draft Genome Sequence of Kibdelosporangium philippinense, Generated by Hybrid Assembly of Short and Long Sequencing Reads by Fedorov, Eugenia A, Omeragic, Medina, Shalygina, Kristina F, Farwell, Ashlyn C, MacLea, Kyle S

“…The glycopeptide antibiotic-producing soil actinobacterium Kibdelosporangium philippinense A80407 (=ATCC 49844) was sequenced using Illumina and Nanopore…”
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Using Cherenkov Imaging to Verify Anterior Field Match Lines between Supraclavicular and Tangent Whole Breast Irradiation Fields by Hachadorian, R.L., Farwell, C., Gladstone, D.J., Bruza, P., Pogue, B.W., Jarvis, L.A.

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Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo by McIntosh, John A., Coelho, Pedro S., Farwell, Christopher C., Wang, Z. Jane, Lewis, Jared C., Brown, Tristan R., Arnold, Frances H.

“…Stickstoffaktivierung: Obwohl P450‐Enzyme Meister der Aktivierung und Insertion von Sauerstoff in C‐H‐Bindungen sind, wurde bisher nicht erforscht, ob sie dies…”
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