Search Results - "Farrugia, William"

Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1 by Ramsland, Paul A, Willoughby, Natasha, Trist, Halina M, Farrugia, William, Hogarth, P. Mark, Fraser, John D, Wines, Bruce D

“…Infection by Staphylococcus aureus can result in severe conditions such as septicemia, toxic shock, pneumonia, and endocarditis with antibiotic resistance and…”
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Cold-Induced Precipitation of a Monoclonal IgM: A Negative Activation Enthalpy Reaction by Meliga, Stefano C, Farrugia, William, Ramsland, Paul A, Falconer, Robert J

“…Cold-induced precipitation of a monoclonal IgM cryoglobulin isolated from a patient with Waldenström’s macroglobulinemia was observed to have a negative…”
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A possible role for metallic ions in the carbohydrate cluster recognition displayed by a Lewis Y specific antibody by Farrugia, William, Scott, Andrew M, Ramsland, Paul A

“…Lewis Y (Le(y)) is a blood group-related carbohydrate that is expressed at high surface densities on the majority of epithelial carcinomas and is a promising…”
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Three-dimensional structures of carbohydrate determinants of Lewis system antigens: Implications for effective antibody targeting of cancer by Yuriev, Elizabeth, Farrugia, William, Scott, Andrew M, Ramsland, Paul A

“…Lewis system carbohydrate antigens have been shown to be expressed at high levels in many cancers of epithelial cell origin, including those of colon, breast,…”
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Structural convergence of antibody binding of carbohydrate determinants in Lewis Y tumor antigens by Ramsland, Paul A, Farrugia, William, Bradford, Tessa M, Mark Hogarth, P, Scott, Andrew M

“…Antibodies targeting human epithelial carcinomas bearing Lewis Y (Le(y)) carbohydrate antigens provide a striking illustration of convergent immune…”
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Structural Basis for FcγRIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes by Ramsland, Paul A., Farrugia, William, Bradford, Tessa M., Sardjono, Caroline Tan, Esparon, Sandra, Trist, Halina M., Powell, Maree S., Tan, Peck Szee, Cendron, Angela C., Wines, Bruce D., Scott, Andrew M., Hogarth, P. Mark

“…Abstract The interaction of Abs with their specific FcRs is of primary importance in host immune effector systems involved in infection and inflammation, and…”
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Global conformational changes in IgG-Fc upon mutation of the FcRn-binding site are not associated with altered antibody-dependent effector functions by Burvenich, Ingrid J G, Farrugia, William, Liu, Zhanqi, Makris, Dahna, King, Dylan, Gloria, Benjamin, Perani, Angelo, Allan, Laura C, Scott, Andrew M, Ramsland, Paul A

“…Antibody engineering is important for many diagnostic and clinical applications of monoclonal antibodies. We recently reported a series of fragment…”
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An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes by Sterjovski, Jasminka, Roche, Michael, Churchill, Melissa J, Ellett, Anne, Farrugia, William, Gray, Lachlan R, Cowley, Daniel, Poumbourios, Pantelis, Lee, Benhur, Wesselingh, Steven L, Cunningham, Anthony L, Ramsland, Paul A, Gorry, Paul R

“…Abstract While CCR5 is the principal coreceptor used by macrophage (M)-tropic HIV-1, not all primary CCR5-using (R5) viruses enter macrophages efficiently…”
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Cross-species analysis of Fc engineered anti-Lewis-Y human IgG1 variants in human neonatal receptor transgenic mice reveal importance of S254 and Y436 in binding human neonatal Fc receptor by Burvenich, Ingrid J G, Farrugia, William, Lee, Fook T, Catimel, Bruno, Liu, Zhanqi, Makris, Dahna, Cao, Diana, O'Keefe, Graeme J, Brechbiel, Martin W, King, Dylan, Spirkoska, Violeta, Allan, Laura C, Ramsland, Paul A, Scott, Andrew M

“…IgG has a long half-life through engagement of its Fc region with the neonatal Fc receptor (FcRn). The FcRn binding site on IgG1 has been shown to contain I253…”
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Construction of single-chain Fv with two possible CDR3H conformations but similar inter-molecular forces that neutralize bovine herpesvirus 1 by Koti, Madhuri, Farrugia, William, Nagy, Eva, Ramsland, Paul A., Kaushik, Azad K.

“…Bovine herpesvirus 1 (BoHV-1) causes respiratory and genital diseases in cattle for which available vaccines do not confer adequate protection. Since passive…”
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CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120–CD4 interactions and fusogenicity by Sterjovski, Jasminka, Churchill, Melissa J, Roche, Michael, Ellett, Anne, Farrugia, William, Wesselingh, Steven L, Cunningham, Anthony L, Ramsland, Paul A, Gorry, Paul R

“…Abstract CD4-binding site (CD4bs) alterations in gp120 contribute to different pathophysiological phenotypes of CCR5-using (R5) HIV-1 strains, but the…”
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Carbohydrate-mimetic peptides: structural aspects of mimicry and therapeutic implications by Agostino, Mark, Sandrin, Mauro S, Thompson, Philip E, Farrugia, William, Ramsland, Paul A, Yuriev, Elizabeth

“…The existence of specific carbohydrates on the surface of a wide range of cells provides the opportunity for the development of highly targeted therapeutic…”
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Structural biology of carbohydrate xenoantigens by Yuriev, Elizabeth, Agostino, Mark, Farrugia, William, Christiansen, Dale, Sandrin, Mauro S, Ramsland, Paul A

“…Transplantation of organs across species (xenotransplantation) is being considered to overcome the shortage of human donor organs. However, unmodified pig…”
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A conserved host and pathogen recognition site on immunoglobulins: structural and functional aspects by Wines, Bruce D, Trist, Halina M, Farrugia, William, Ngo, Chloe, Trowsdale, John, Areschoug, Thomas, Lindahl, Gunnar, Fraser, John D, Ramsland, Paul A

“…A common site in the constant region (Fc) of immunoglobulins is recognized by host receptors and is a frequent target of proteins expressed by pathogens. This…”
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Non-canonical anchor motif peptides bound to MHC class I induce cellular responses by Lazoura, Eliada, Lodding, Jodie, Farrugia, William, Day, Stephanie, Ramsland, Paul A., Apostolopoulos, Vasso

“…The major histocompatibility complex (MHC) on the surface of antigen presenting cells functions to display peptides to the T cell receptor (TCR). Recognition…”
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Structural Basis for Fc[gamma]RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes by Ramsland, Paul A., Farrugia, William, Bradford, Tessa M., Sardjono, Caroline Tan, Esparon, Sandra, Trist, Halina M., Powell, Maree S., Tan, Peck Szee, Cendron, Angela C., Wines, Bruce D., Scott, Andrew M., Hogarth, P. Mark

“…The interaction of Abs with their specific FcRs is of primary importance in host immune effector systems involved in infection and inflammation, and are the…”
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Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody by Ramsland, Paul A, Terzyan, Simon S, Cloud, Gwendolyn, Bourne, Christina R, Farrugia, William, Tribbick, Gordon, Geysen, H Mario, Moomaw, Carolyn R, Slaughter, Clive A, Edmundson, Allen B

“…The 2.6 A (1 A=0.1 nm) resolution structure has been determined for the glycosylated Fab (fragment antigen binding) of an IgM (Yvo) obtained from a subject…”
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Enhanced major histocompatibility complex class I binding and immune responses through anchor modification of the non‐canonical tumour‐associated mucin 1‐8 peptide by Lazoura, Eliada, Lodding, Jodie, Farrugia, William, Ramsland, Paul A., Stevens, James, Wilson, Ian A., Pietersz, Geoffrey A., Apostolopoulos, Vasso

“…Summary Designing peptide‐based vaccines for therapeutic applications in cancer immunotherapy requires detailed knowledge of the interactions between the…”
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Special Feature: Three-dimensional structures of carbohydrate determinants of Lewis system antigens: Implications for effective antibody targeting of cancer by Yuriev, Elizabeth, Farrugia, William, Scott, Andrew M, Ramsland, Paul A

“…Summary Lewis system carbohydrate antigens have been shown to be expressed at high levels in many cancers of epithelial cell origin, including those of colon,…”
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Crystal structures of human antibodies: a detailed and unfinished tapestry of immunoglobulin gene products by Ramsland, Paul A., Farrugia, William

“…Sequencing of all human immunoglobulin (Ig) germline gene segments has recently been completed. However, our first glimpses of the recombined products of this…”
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