Search Results - "Farrugia, Brooke"

The Glycosaminoglycan Side Chains and Modular Core Proteins of Heparan Sulphate Proteoglycans and the Varied Ways They Provide Tissue Protection by Regulating Physiological Processes and Cellular Behaviour by Farrugia, Brooke L, Melrose, James

“…This review examines the roles of HS-proteoglycans (HS-PGs) in general, and, in particular, perlecan and syndecan as representative examples and their…”
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Sensors and imaging for wound healing: A review by Dargaville, Tim R., Farrugia, Brooke L., Broadbent, James A., Pace, Stephanie, Upton, Zee, Voelcker, Nicolas H.

“…Wound healing involves a complex series of biochemical events and has traditionally been managed with ‘low tech’ dressings and bandages. The concept that…”
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The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies by Farrugia, Brooke L., Lord, Megan S., Melrose, James, Whitelock, John M.

“…Key events that occur during inflammation include the recruitment, adhesion, and transmigration of leukocytes from the circulation to the site of inflammation…”
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Arthritis and Duchenne muscular dystrophy: the role of chondroitin sulfate and its associated proteoglycans in disease pathology and as a diagnostic marker by Maciej-Hulme, Marissa L, Melrose, James, Farrugia, Brooke L

“…Chondroitin sulfate (CS) is a ubiquitous glycosaminoglycan covalently attached to the core proteins of cell surface, extracellular, and intracellular…”
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Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan by Elgundi, Zehra, Papanicolaou, Michael, Major, Gretel, Cox, Thomas R, Melrose, James, Whitelock, John M, Farrugia, Brooke L

“…Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation of secondary tumors. This process is complex and is spatially…”
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Platelet Factor 4 Binds to Vascular Proteoglycans and Controls Both Growth Factor Activities and Platelet Activation by Lord, Megan S., Cheng, Bill, Farrugia, Brooke L., McCarthy, Simon, Whitelock, John M.

“…Platelet factor 4 (PF4) is produced by platelets with roles in both inflammation and wound healing. PF4 is stored in platelet α-granules bound to the…”
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Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing by Lord, Megan S., Ellis, April L., Farrugia, Brooke L., Whitelock, John M., Grenett, Hernan, Li, Chuanyu, O'Grady, Robert L., DeCarlo, Arthur A.

“…The repair of dermal wounds, particularly in the diabetic population, poses a significant healthcare burden. The impaired wound healing of diabetic wounds is…”
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Covalent Incorporation of Heparin Improves Chondrogenesis in Photocurable Gelatin‐Methacryloyl Hydrogels by Brown, Gabriella C. J., Lim, Khoon S., Farrugia, Brooke L., Hooper, Gary J., Woodfield, Tim B. F.

“…Multicomponent gelatin‐methacryloyl (GelMA) hydrogels are regularly adopted for cartilage tissue engineering (TE) applications, where optimizing chemical…”
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Perlecan, A Multi-Functional, Cell-Instructive, Matrix-Stabilizing Proteoglycan With Roles in Tissue Development Has Relevance to Connective Tissue Repair and Regeneration by Hayes, Anthony J, Farrugia, Brooke L, Biose, Ifechukwude J, Bix, Gregory J, Melrose, James

“…This review highlights the multifunctional properties of perlecan (HSPG2) and its potential roles in repair biology. Perlecan is ubiquitous, occurring in…”
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Poly(2-oxazoline) Hydrogels for Controlled Fibroblast Attachment by Farrugia, Brooke L, Kempe, Kristian, Schubert, Ulrich S, Hoogenboom, Richard, Dargaville, Tim R

“…Currently there is a lack of choice when selecting synthetic materials with the cell-instructive properties demanded by modern biomaterials. The purpose of…”
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Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard? by Farrugia, Brooke L, Lord, Megan S, Melrose, James, Whitelock, John M

“…Heparan sulfate (HS) and heparin are glycosaminoglycans (GAGs) that are heterogeneous in nature, not only due to differing disaccharide combinations, but also…”
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Chitosan-collagen scaffolds with nano/microfibrous architecture for skin tissue engineering by Sarkar, Soumi Dey, Farrugia, Brooke L., Dargaville, Tim R., Dhara, Santanu

“…In this study, a hierarchical nano/microfibrous chitosan/collagen scaffold that approximates structural and functional attributes of native extracellular…”
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Controlled oxygen delivery to power tissue regeneration by Zoneff, Elizabeth, Wang, Yi, Jackson, Colin, Smith, Oliver, Duchi, Serena, Onofrillo, Carmine, Farrugia, Brooke, Moulton, Simon E., Williams, Richard, Parish, Clare, Nisbet, David R., Caballero-Aguilar, Lilith M.

“…Oxygen plays a crucial role in human embryogenesis, homeostasis, and tissue regeneration. Emerging engineered regenerative solutions call for novel oxygen…”
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Hyaluronidase-4 is produced by mast cells and can cleave serglycin chondroitin sulfate chains into lower molecular weight forms by Farrugia, Brooke L., Mizumoto, Shuji, Lord, Megan S., O’Grady, Robert L., Kuchel, Rhiannon P., Yamada, Shuhei, Whitelock, John M.

“…Mast cells represent a heterogeneous cell population that is well-known for the production of heparin and the release of histamine upon activation. Serglycin…”
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Poly(2-oxazoline) Hydrogel Monoliths via Thiol-ene Coupling by Dargaville, Tim R., Forster, Rebecca, Farrugia, Brooke L., Kempe, Kristian, Voorhaar, Lenny, Schubert, Ulrich S., Hoogenboom, Richard

“…Copoly(2‐oxazoline)s, prepared by the cationic ring‐opening polymerization of 2‐(dec‐9‐enyl)‐2‐oxazoline with either 2‐methyl‐2‐oxazoline or…”
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Dermal fibroblast infiltration of poly(ε-caprolactone) scaffolds fabricated by melt electrospinning in a direct writing mode by Farrugia, Brooke L, Brown, Toby D, Upton, Zee, Hutmacher, Dietmar W, Dalton, Paul D, Dargaville, Tim R

“…Melt electrospinning in a direct writing mode is a recent additive manufacturing approach to fabricate porous scaffolds for tissue engineering applications. In…”
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Poly(2-allylamidopropyl-2-oxazoline)-Based Hydrogels: From Accelerated Gelation Kinetics to In Vivo Compatibility in a Murine Subdermal Implant Model by Dargaville, Tim R, Harkin, Damien G, Park, Jong-Ryul, Cavalcanti, Amanda, Bolle, Eleonore C. L, Savi, Flavia Medeiros, Farrugia, Brooke L, Monnery, Bryn D, Bernhard, Yann, Van Guyse, Joachim F. R, Podevyn, Annelore, Hoogenboom, Richard

“…A rapid photo-curing system based on poly­(2-ethyl-2-oxazoline-co-2-allylamidopropyl-2-oxazoline) and its in vivo compatibility are presented. The base polymer…”
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Chitosan‐Based Heparan Sulfate Mimetics Promote Epidermal Formation in a Human Organotypic Skin Model by Farrugia, Brooke L., Mi, Yaolei, Kim, Ha Na, Whitelock, John M., Baker, Shenda M., Wiesmann, William P., Li, Zhe, Maitz, Peter, Lord, Megan S.

“…Biomimetic materials that replicate biological functions have great promise for use as therapeutics in regenerative medicine applications. Heparan sulfate (HS)…”
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A review of simulation training and new 3D computer-generated synthetic organs for robotic surgery education by Costello, Daniel M., Huntington, Isabel, Burke, Grace, Farrugia, Brooke, O’Connor, Andrea J., Costello, Anthony J., Thomas, Benjamin C., Dundee, Philip, Ghazi, Ahmed, Corcoran, Niall

“…We conducted a comprehensive review of surgical simulation models used in robotic surgery education. We present an assessment of the validity and…”
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Mast Cells Produce a Unique Chondroitin Sulfate Epitope by Farrugia, Brooke L., Whitelock, John M., O’Grady, Robert, Caterson, Bruce, Lord, Megan S.

“…The granules of mast cells contain a myriad of mediators that are stored and protected by the sulfated glycosaminoglycan (GAG) chains that decorate…”
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