Search Results - "Farrokhi, Catherine"

Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse by Currais, Antonio, Farrokhi, Catherine, Dargusch, Richard, Armando, Aaron, Quehenberger, Oswald, Schubert, David, Maher, Pamela

“…Alzheimer's disease (AD) is rarely addressed in the context of aging even though there is an overlap in pathology. We previously used a phenotypic screening…”
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Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model by Xu, Jiqing, de Winter, Fred, Farrokhi, Catherine, Rockenstein, Edward, Mante, Michael, Adame, Anthony, Cook, Jonathan, Jin, Xin, Masliah, Eliezer, Lee, Kuo-Fen

“…Several lines of evidence suggest that neuregulin 1 (NRG1) signaling may influence cognitive function and neuropathology in Alzheimer’s disease (AD). To test…”
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A comprehensive multiomics approach toward understanding the relationship between aging and dementia by Currais, Antonio, Goldberg, Joshua, Farrokhi, Catherine, Chang, Max, Prior, Marguerite, Dargusch, Richard, Daugherty, Daniel, Armando, Aaron, Quehenberger, Oswald, Maher, Pamela, Schubert, David

“…Because age is the greatest risk factor for sporadic Alzheimer's disease (AD), phenotypic screens based upon old age-associated brain toxicities were used to…”
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Antidepressants stimulate hippocampal neurogenesis by inhibiting p21 expression in the subgranular zone of the hipppocampus by Pechnick, Robert N, Zonis, Svetlana, Wawrowsky, Kolja, Cosgayon, Rosemarie, Farrokhi, Catherine, Lacayo, Liliana, Chesnokova, Vera

“…The relationships among hippocampal neurogenesis, depression and the mechanism of action of antidepressant drugs have generated a considerable amount of…”
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A Novel Bicistronic High-Capacity Gutless Adenovirus Vector That Drives Constitutive Expression of Herpes Simplex Virus Type 1 Thymidine Kinase and Tet-Inducible Expression of Flt3L for Glioma Therapeutics by Puntel, Mariana, Muhammad, A K M G, Candolfi, Marianela, Salem, Alireza, Yagiz, Kader, Farrokhi, Catherine, Kroeger, Kurt M, Xiong, Weidong, Curtin, James F, Liu, Chunyan, Bondale, Niyati S, Lerner, Jonathan, Pechnick, Robert N, Palmer, Donna, Ng, Philip, Lowenstein, Pedro R, Castro, Maria G

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Gene therapy for brain cancer: combination therapies provide enhanced efficacy and safety by Candolfi, Marianela, Kroeger, Kurt M, Muhammad, A K M G, Yagiz, Kader, Farrokhi, Catherine, Pechnick, Robert N, Lowenstein, Pedro R, Castro, Maria G

“…Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults. Despite significant advances in treatment and intensive research, the…”
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Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology by Larocque, Daniel, Sanderson, Nicholas S R, Bergeron, Josée, Curtin, James F, Girton, Joe, Wibowo, Mia, Bondale, Niyati, Kroeger, Kurt M, Yang, Jieping, Lacayo, Liliana M, Reyes, Kevin C, Farrokhi, Catherine, Pechnick, Robert N, Castro, Maria G, Lowenstein, Pedro R

“…Soluble antigens diffuse out of the brain and can thus stimulate a systemic immune response, whereas particulate antigens (from infectious agents or tumor…”
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Activation of central CRF receptor 1 by cortagine results in enhanced passive coping with a naturalistic threat in mice by Tovote, Philip, Farrokhi, Catherine Borna, Gonzales, Rachael M.K, Schnitzbauer, Udo, Blanchard, D. Caroline, Blanchard, Robert J, Spiess, Joachim

“…Summary CRF receptor subtype 1 (CRF1), abundantly expressed in the central nervous system, has been implicated in defensive behavior in rodents…”
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Effects of the CRF1 antagonist SSR125543A on aggressive behaviors in hamsters by Farrokhi, Catherine, Blanchard, D.Caroline, Griebel, Guy, Yang, Mu, Gonzales, Coty, Markham, Chris, Blanchard, Robert J.

“…Corticotropin-releasing factor (CRF) and its receptor subtypes have been implicated in endocrine and behavioral responsivity to stress and emotion, including…”
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Depletion of Brain Perivascular Macrophages Mitigates Depressive‐like Behavioral Consequences of Chronic Mild Stress by Grigoleit, Jan‐Sebastian, Alvarez, Elena, Farrokhi, Catherine Borna, Sawchenko, Paul E.

“…Abstract only Despite intensive research, the etiology of depression remains poorly understood. Stress is implicated in the pathogenesis of most depressive…”
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Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery by Prior, Marguerite, Goldberg, Joshua, Chiruta, Chandramouli, Farrokhi, Catherine, Kopynets, Mariya, Roberts, Amanda J., Schubert, David

“…Neurons die in Alzheimer's disease (AD) and are not effectively replaced. An alternative approach to maintain nerve cell number is to identify compounds that…”
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Selecting for neurogenic potential as an alternative for Alzheimer's drug discovery by Prior, Marguerite, Goldberg, Joshua, Chiruta, Chandramouli, Farrokhi, Catherine, Kopynets, Mariya, Roberts, Amanda J, Schubert, David

“…Abstract Introduction Neurons die in Alzheimer's disease (AD) and are not effectively replaced. An alternative approach to maintain nerve cell number is to…”
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Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma by Puntel, Mariana, A.K.M., Ghulam Muhammad, Farrokhi, Catherine, VanderVeen, Nathan, Paran, Christopher, Appelhans, Ashley, Kroeger, Kurt M., Salem, Alireza, Lacayo, Liliana, Pechnick, Robert N., Kelson, Kyle R., Kaur, Sukhpreet, Kennedy, Sean, Palmer, Donna, Ng, Philip, Liu, Chunyan, Krasinkiewicz, Johnny, Lowenstein, Pedro R., Castro, Maria G.

“…Adenoviral vectors (Ads) are promising gene delivery vehicles due to their high transduction efficiency; however, their clinical usefulness has been hampered…”
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AVP V1b selective antagonist SSR149415 blocks aggressive behaviors in hamsters by BLANCHARD, Robert J, GRIEBEL, Guy, FARROKHI, Catherine, MARKHAM, Chris, MU YANG, BLANCHARD, D. Caroline

“…Arginine vasopressin (AVP) has been implicated in a variety of physiological and behavioral responses to stress. Synthesis of receptor-selective AVP agonist…”
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Cognitive impairment and decreased hippocampal neurogenesis after treatment with chemotherapeutic drugs by Pechnick, Robert N, Reyes, Kevin C, Das, Melanie, Lacayo, Liliana M, Farrokhi, Catherine, Zonis, Svetlana, Chesnokova, Vera

“…Post‐chemotherapy cognitive impairment has long been recognized in cancer survivors; however, at the present time the cause(s) is not known. The objective of…”
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Age‐dependent differences in antidepressant response by Lacayo, Liliana Margarita, Farrokhi, Catherine, Manalo, Charlene M, Reyes, Kevin C, Pechnick, Robert N

“…Abstract only The efficacy of tricyclic antidepressant treatment in children and adolescents is highly controversial. This investigation examined potential…”
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Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigenwithoutcausingautoimmuneneuropathology by Larocque, Daniel, Sanderson, Nicholas S. R., Bergeron, Josée, Curtin, James F., Girton, Joe, Wibowo, Mia, Bondale, Niyati, Kroeger, Kurt M., Yang, Jieping, Lacayo, Liliana M., Reyes, Kevin C., Farrokhi, Catherine, Pechnick, Robert N., Castro, Maria G., Lowenstein, Pedro R., Koprowski, Hilary

“…Soluble antigens diffuse out of the brain and can thus stimulate a systemic immune response, whereas particulate antigens (from infectious agents or tumor…”
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Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial by Muhammad, A K M Ghulam, Xiong, Weidong, Puntel, Mariana, Farrokhi, Catherine, Kroeger, Kurt M, Salem, Alireza, Lacayo, Liliana, Pechnick, Robert N, Kelson, Kyle R, Palmer, Donna, Ng, Philip, Liu, Chunyan, Lowenstein, Pedro R, Castro, Maria G

“…Adenoviral vectors (Ads) have been evaluated in clinical trials for glioma. However, systemic immunity against the vectors can hamper therapeutic efficacy. We…”
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Acamprosate attenuates cue-induced reinstatement of nicotine-seeking behavior in rats by Pechnick, Robert N, Manalo, Charlene M, Lacayo, Liliana M, Vit, Jean-Philippe, Bholat, Yasmin, Spivak, Inna, Reyes, Kevin C, Farrokhi, Catherine

“…Acamprosate is used in the treatment of alcoholism; however, there is little information on its effects on nicotine addiction. The objective of this study was…”
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Central infusion of ovine CRF (oCRF) potentiates defensive behaviors in CD-1 mice in the Mouse Defense Test Battery (MDTB) by Yang, Mu, Farrokhi, Catherine, Vasconcellos, Amy, Blanchard, Robert J., Blanchard, D. Caroline

“…Following intracerebroventricular (i.c.v.) injection of ovine CRF (oCRF), an endogenous peptide agonist at both CRF1 and CRF2 receptors, defensive behaviors of…”
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