Search Results - "Farris, Diana M"

Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall by Day, Sharlene M., Reeve, Jennifer L., Pedersen, Brian, Farris, Diana M, Myers, Daniel D., Im, Michael, Wakefield, Thomas W., Mackman, Nigel, Fay, William P.

“…Leukocytes and leukocyte-derived microparticles contain low levels of tissue factor (TF) and incorporate into forming thrombi. Although this circulating pool…”
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Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis by Ramacciotti, Eduardo, Hawley, Angela E, Farris, Diana M, Ballard, Nicole E, Wrobleski, Shirley K, Myers, Jr, Daniel D, Henke, Peter K, Wakefield, Thomas W

“…Microparticles (MP) are lipid vesicles from platelets, leukocytes and endothelial cells that are involved in early thrombogenesis. We evaluated a detailed…”
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Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis by Diaz, Jose A., MD, Ballard-Lipka, Nicole E., BS, Farris, Diana M., LVT, Hawley, Angela E., MS, Wrobleski, Shirley K., BS, Myers, Daniel D., DVM, Henke, Peter K., MD, Lawrence, Daniel A., PhD, Wakefield, Thomas W., MD

“…Background Hyperlipidemia increases the level of blood plasminogen activator inhibitor-1 (PAI-1) that is responsible for regulating fibrinolysis by inhibiting…”
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Low-molecular-weight heparin modulates vein wall fibrotic response in a plasminogen activator inhibitor 1-dependent manner by Obi, Andrea T., MD, Diaz, Jose A., MD, Ballard-Lipka, Nicole L., BS, Roelofs, Karen J., DVM, Farris, Diana M., LVT, Lawrence, Daniel A., PhD, Henke, Peter K., MD, Wakefield, Thomas W., MD

“…Background Treatment with low-molecular-weight heparin (LMWH) favorably alters the vein wall response to deep venous thrombosis (DVT), although the mechanisms…”
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Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation by Myers, Jr, Daniel D, Wrobleski, Shirley K, Longo, Chris, Bedard, Patricia W, Kaila, Neelu, Shaw, George D, Londy, Frank J, Rohrer, Suzan E, Fex, Beverly A, Zajkowski, Paul J, Meier, Thomas R, Hawley, Angela E, Farris, Diana M, Ballard, Nicole E, Henke, Peter K, Schaub, Robert G, Wakefield, Thomas W

“…P-selectin inhibition has been shown to decrease thrombogenesis in multiple animal species. In this study, we show that a novel oral small-molecule inhibitor…”
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Mouse complete stasis model of inferior vena cava thrombosis by Wrobleski, Shirley K, Farris, Diana M, Diaz, José A, Myers, Jr, Daniel D, Wakefield, Thomas W

“…Venous thromboembolism (VTE) includes both deep vein thrombosis (DVT) and pulmonary embolism (PE). In the United States (U.S.), the high morbidity and…”
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The electrolytic inferior vena cava model (EIM) to study thrombogenesis and thrombus resolution with continuous blood flow in the mouse by Diaz, Jose A, Alvarado, Christine M, Wrobleski, Shirley K, Slack, Dallas W, Hawley, Angela E, Farris, Diana M, Henke, Peter K, Wakefield, Thomas W, Myers, Jr, Daniel D

“…Previously, we presented the electrolytic inferior vena cava (IVC) model (EIM) during acute venous thrombosis (VT). Here, we present our evaluation of the EIM…”
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P-selectin and leukocyte microparticles are associated with venous thrombogenesis by Myers, Daniel D., Hawley, Angela E., Farris, Diana M., Wrobleski, Shirley K., Thanaporn, Porama, Schaub, Robert G., Wagner, Denisa D., Kumar, Anjali, Wakefield, Thomas W.

“…P-selectin inhibition has been found to limit venous thrombosis. We hypothesize that elevated levels of P-selectin will amplify thrombosis, mediated by…”
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Decreased venous thrombosis with an oral inhibitor of P selectin by Myers, Daniel D., Rectenwald, John E., Bedard, Patricia W., Kaila, Neelu, Shaw, Gray D., Schaub, Robert G., Farris, Diana M., Hawley, Angela E., Wrobleski, Shirley K., Henke, Peter K., Wakefield, Thomas W.

“…P-selectin inhibition with protein therapeutics such as antibodies or soluble ligands given intravenously can decrease thrombosis in a mouse ligation model of…”
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Aging is associated with impaired thrombus resolution in a mouse model of stasis induced thrombosis by McDonald, April P, Meier, Thomas R, Hawley, Angela E, Thibert, Jacklyn N, Farris, Diana M, Wrobleski, Shirley K, Henke, Peter K, Wakefield, Thomas W, Myers, Daniel D

“…Abstract Introduction To evaluate the effects of aging on venous thrombosis. Material and Methods Anesthetized male mice (C57BL/6, n = 125) underwent complete…”
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1D-1H-nuclear magnetic resonance metabolomics reveals age-related changes in metabolites associated with experimental venous thrombosis by Obi, Andrea T., Stringer, Kathleen A., Diaz, Jose A., Finkel, Michael A., Farris, Diana M., Yeomans, Larisa, Wakefield, Thomas, Myers, Daniel D.

“…Age is a significant risk factor for the development of venous thrombosis (VT), but the mechanism(s) that underlie this risk remain(s) undefined and poorly…”
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P-selectin inhibition decreases post-thrombotic vein wall fibrosis in a rat model by Thanaporn, Porama, Myers, Daniel D., Wrobleski, Shirley K., Hawley, Angela E., Farris, Diana M., Wakefield, Thomas W., Henke, Peter K.

“…Background. Post-deep vein thrombosis (DVT) venous insufficiency is a vexing problem despite effective anticoagulation, and is characterized by vein wall…”
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P-selectin inhibition enhances thrombus resolution and decreases vein wall fibrosis in a rat model by Myers, Daniel D., Henke, Peter K., Wrobleski, Shirley K., Hawley, Angela E., Farris, Diana M., Chapman, Amy M., Knipp, Brian S., Thanaporn, Porama, Schaub, Robert G., Greenfield, Lazar J., Wakefield, Thomas W.

“…Purpose: The purpose of this study was to compare the efficacy of P-selectin inhibition with standard anticoagulant and thrombolytic therapy in a rodent model…”
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Cellular IL-10 is more effective than viral IL-10 in decreasing venous thrombosis by Myers, Jr, Daniel D, Hawley, Angela E, Farris, Diana M, Chapman, Amy M, Wrobleski, Shirley K, Henke, Peter K, Wakefield, Thomas W

“…Systemic administration of cellular interleukin-10 (cIL-10) and gene transfection of viral interleukin-10 (vIL-10) at thrombus induction decreases vein wall…”
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Abstract 24: Resolvin D2 Reduces Thrombus Burden and Attenuates Inflammatory Signaling Pathways in a Murine Model of Venous Thrombosis by Diaz, Jose A, Shaydakov, Maxim E, Chatterjee, Anuran, Farris, Diana M, Ballard-Lipka, Nicole E, Hawley, Angela E, Sigler, Robert E, Henke, Peter K, Myers, Daniel D, Wakefield, Thomas W, Conte, Michael S

“…Abstract only Background: Specialized pro-resolving lipid mediators (SPM) derived from polyunsaturated fatty acids, such as Resolvin D2 (RvD2), play a critical…”
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PAI-1 over-expression decreases experimental post-thrombotic vein wall fibrosis by a non-vitronectin dependent mechanism by Obi, Andrea T., Diaz, Jose A., Ballard-Lipka, Nicole L., Roelofs, Karen J., Farris, Diana M., Lawrence, Daniel A., Wakefield, Thomas W., Henke, Peter K.

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Abstract 196: Matrix Metalloproteinases Regulation in Thrombus Resolution Is Independent of TGF-β in a PAI-1 Ko Mouse Model of Venous Thrombosis by Obi, Andrea T, Wakefield, Thomas W, Ballard-Lipka, Nicole E, Farris, Diana M, Myers, Daniel D, Henke, Peter K, Diaz, Jose A

“…Abstract only Introduction: Plasminogen activator inhibitor (PAI-1) is the primary regulator of urokinase (u-PA) and tissue (t-PA) plasminogen activators…”
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Mouse Complete Stasis Model of Inferior Vena Cava Thrombosis by Wrobleski, Shirley K., Farris, Diana M., Diaz, José A., Myers Jr, Daniel D., Wakefield, Thomas W.

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1D-1 H-nuclear magnetic resonance metabolomics reveals age-related changes in metabolites associated with experimental venous thrombosis by Obi, Andrea T., MD, Stringer, Kathleen A., PharmD, Diaz, Jose A., MD, Finkel, Michael A., BA, Farris, Diana M., LVT, Yeomans, Larisa, PhD, Wakefield, Thomas, MD, Myers, Daniel D., DVM

“…Objective Age is a significant risk factor for the development of venous thrombosis (VT), but the mechanism(s) that underlie this risk remain(s) undefined and…”
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Cellular IL-10 is more effective than viral IL-10 in decreasing venous thrombosis 1,2 by Myers, Daniel D, Hawley, Angela E, Farris, Diana M, Chapman, Amy M, Wrobleski, Shirley K, Henke, Peter K, Wakefield, Thomas W

“…Background. Systemic administration of cellular interleukin-10 (cIL-10) and gene transfection of viral interleukin-10 (vIL-10) at thrombus induction decreases…”
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