Search Results - "Farris, Carly M."

Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid by Concha-Marambio, Luis, Pritzkow, Sandra, Shahnawaz, Mohammad, Farris, Carly M., Soto, Claudio

“…Misfolded alpha-synuclein (αSyn) aggregates are a hallmark event in Parkinson’s disease (PD) and other synucleinopathies. Recently, αSyn seed amplification…”
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High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease by Russo, Marco J, Orru, Christina D, Concha-Marambio, Luis, Giaisi, Simone, Groveman, Bradley R, Farris, Carly M, Holguin, Bret, Hughson, Andrew G, LaFontant, David-Erick, Caspell-Garcia, Chelsea, Coffey, Christopher S, Mollon, Jennifer, Hutten, Samantha J, Merchant, Kalpana, Heym, Roland G, Soto, Claudio, Caughey, Byron, Kang, Un Jung

“…Alpha-synuclein seed amplification assays (αSyn-SAAs) are promising diagnostic tools for Parkinson's disease (PD) and related synucleinopathies. They enable…”
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Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays by Bellomo, Giovanni, Paciotti, Silvia, Concha-Marambio, Luis, Rizzo, Domenico, Wojdaƚa, Anna Lidia, Chiasserini, Davide, Gatticchi, Leonardo, Cerofolini, Linda, Giuntini, Stefano, De Luca, Chiara Maria Giulia, Ma, Yihua, Farris, Carly M, Pieraccini, Giuseppe, Bologna, Sara, Filidei, Marta, Ravera, Enrico, Lelli, Moreno, Moda, Fabio, Fragai, Marco, Parnetti, Lucilla, Luchinat, Claudio

“…Aggregation of α-synuclein (α-syn) is a prominent feature of Parkinson's disease (PD) and other synucleinopathies. Currently, α-syn seed amplification assays…”
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Correction to: High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease by Russo, Marco J, Orru, Christina D, Concha-Marambio, Luis, Giaisi, Simone, Groveman, Bradley R, Farris, Carly M, Holguin, Bret, Hughson, Andrew G, LaFontant, David-Erick, Caspell-Garcia, Chelsea, Cofey, Christopher S, Mollon, Jennifer, Hutten, Samantha J, Merchant, Kalpana, Heym, Roland G, Soto, Claudio, Caughey, Byron, Kang, Un Jung

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Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study by Siderowf, Andrew, Concha-Marambio, Luis, Lafontant, David-Erick, Farris, Carly M, Ma, Yihua, Urenia, Paula A, Nguyen, Hieu, Alcalay, Roy N, Chahine, Lana M, Foroud, Tatiana, Galasko, Douglas, Kieburtz, Karl, Merchant, Kalpana, Mollenhauer, Brit, Poston, Kathleen L, Seibyl, John, Simuni, Tanya, Tanner, Caroline M, Weintraub, Daniel, Videnovic, Aleksandar, Choi, Seung Ho, Kurth, Ryan, Caspell-Garcia, Chelsea, Coffey, Christopher S, Frasier, Mark, Oliveira, Luis M A, Hutten, Samantha J, Sherer, Todd, Marek, Kenneth, Soto, Claudio

“…Emerging evidence shows that α-synuclein seed amplification assays (SAAs) have the potential to differentiate people with Parkinson's disease from healthy…”
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Accurate Detection of α‐Synuclein Seeds in Cerebrospinal Fluid from Isolated Rapid Eye Movement Sleep Behavior Disorder and Patients with Parkinson's Disease in the DeNovo Parkinson (DeNoPa) Cohort by Concha‐Marambio, Luis, Weber, Sandrina, Farris, Carly M., Dakna, Mohammed, Lang, Elisabeth, Wicke, Tamara, Ma, Yihua, Starke, Maritta, Ebentheuer, Jens, Sixel‐Döring, Friederike, Muntean, Maria‐Lucia, Schade, Sebastian, Trenkwalder, Claudia, Soto, Claudio, Mollenhauer, Brit

“…ABSTRACT Background Misfolded α‐synuclein (αSyn) aggregates (αSyn‐seeds) in cerebrospinal fluid (CSF) are biomarkers for synucleinopathies such as Parkinson's…”
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α‐Synuclein Seed Amplification in CSF and Brain from Patients with Different Brain Distributions of Pathological α‐Synuclein in the Context of Co‐Pathology and Non‐LBD Diagnoses by Arnold, Moriah R., Coughlin, David G., Brumbach, Barbara H., Smirnov, Denis S., Concha‐Marambio, Luis, Farris, Carly M., Ma, Yihua, Kim, Yongya, Wilson, Edward N., Kaye, Jeffrey A., Hiniker, Annie, Woltjer, Randy L., Galasko, Doug R., Quinn, Joseph F.

“…Objective The purpose of this study was to determine the sensitivity and specificity of α‐synuclein seed amplification assay (αSyn‐SAA) in antemortem and…”
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α-Synuclein seed amplification assay as a diagnostic tool for parkinsonian disorders by Fernandes Gomes, Bárbara, Farris, Carly M, Ma, Yihua, Concha-Marambio, Luis, Lebovitz, Russ, Nellgård, Bengt, Dalla, Keti, Constantinescu, Julius, Constantinescu, Radu, Gobom, Johan, Andreasson, Ulf, Zetterberg, Henrik, Blennow, Kaj

“…Synucleinopathies such as Parkinson's disease (PD) and multiple system atrophy (MSA) can be challenging to diagnose due to the symptom overlap with, for…”
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Investigating alpha‐synuclein co‐pathology in Alzheimer's disease by means of cerebrospinal fluid alpha‐synuclein seed amplification assay by Bellomo, Giovanni, Toja, Andrea, Paolini Paoletti, Federico, Ma, Yihua, Farris, Carly M., Gaetani, Lorenzo, Salvadori, Nicola, Chiasserini, Davide, Wojdaƚa, Anna Lidia, Concha‐Marambio, Luis, Parnetti, Lucilla

“…INTRODUCTION Lewy body disease, a frequently observed co‐pathology in Alzheimer's disease (AD), can be identified antemortem in cerebrospinal fluid (CSF) by…”
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Seed Amplification Assay to Diagnose Early Parkinson's and Predict Dopaminergic Deficit Progression by Concha‐Marambio, Luis, Farris, Carly M., Holguin, Bret, Ma, Yihua, Seibyl, John, Russo, Marco J., Kang, Un J., Hutten, Samantha J., Merchant, Kalpana, Shahnawaz, Mohammad, Soto, Claudio

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Target engagement and immunogenicity of an active immunotherapeutic targeting pathological α-synuclein: a phase 1 placebo-controlled trial by Eijsvogel, Pepijn, Misra, Pinaki, Concha-Marambio, Luis, Boyd, Justin D., Ding, Shuang, Fedor, Lauren, Hsieh, Yueh-Ting, Sun, Yu Shuang, Vroom, Madeline M., Farris, Carly M., Ma, Yihua, de Kam, Marieke L., Radanovic, Igor, Vissers, Maurits F. J. M., Mirski, Dario, Shareghi, Ghazal, Shahnawaz, Mohammad, Singer, Wolfgang, Kremer, Philip, Groeneveld, Geert Jan, Yu, Hui Jing, Dodart, Jean-Cosme

“…Investigational therapeutics that target toxic species of α-synuclein (αSyn) aim to slow down or halt disease progression in patients with Parkinson’s disease…”
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Chemo-Mechanical Factors That Limit Cellular Force Generation by Vazquez-Hidalgo, Esteban, Farris, Carly M., Rowat, Amy C., Katira, Parag

“…Cellular traction forces that are dependent on actin-myosin activity are necessary for numerous developmental and physiological processes. As traction force…”
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Accurate detection of α-Synuclein seeds in CSF from iRBD and Parkinson patients in the DeNoPa cohort by Concha-Marambio, Luis, Weber, Sandrina, Farris, Carly M., Dakna, Mohammed, Lang, Elisabeth, Wicke, Tamara, Ma, Yihua, Starke, Maritta, Ebentheuer, Jens, Sixel-Döring, Friederike, Muntean, Maria-Lucia, Schade, Sebastian, Trenkwalder, Claudia, Soto, Claudio, Mollenhauer, Brit

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Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study by Ma, Yihua, Farris, Carly M, Weber, Sandrina, Schade, Sebastian, Nguyen, Hieu, Pérez-Soriano, Alexandra, Giraldo, Darly M, Fernández, Manel, Soto, Marta, Cámara, Ana, Painous, Celia, Muñoz, Esteban, Valldeoriola, Francesc, Martí, Maria J, Clarimon, Jordi, Kallunki, Pekka, Ma, Thong Chi, Alcalay, Roy N, Gomes, Bárbara Fernandez, Blennow, Kaj, Zetterberg, Henrik, Constantinescu, Julius, Mengel, David, Kadam, Vaibhavi, Parchi, Piero, Brockmann, Kathrin, Tropea, Thomas F, Siderowf, Andrew, Synofzik, Matthis, Kang, Un Jung, Compta, Yaroslau, Svenningsson, Per, Mollenhauer, Brit, Concha-Marambio, Luis

“…The pathological hallmarks of multiple system atrophy and Parkinson's disease are, respectively, misfolded-α-synuclein-laden glial cytoplasmic inclusions and…”
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Cerebrospinal fluid lipoproteins inhibit [alpha]-synuclein aggregation by interacting with oligomeric species in seed amplification assays by Bellomo, Giovanni, Paciotti, Silvia, Concha-Marambio, Luis, Rizzo, Domenico, WojdaÆa, Anna Lidia, Chiasserini, Davide, Gatticchi, Leonardo, Cerofolini, Linda, Giuntini, Stefano, De Luca, Chiara Maria Giulia, Ma, Yihua, Farris, Carly M, Pieraccini, Giuseppe, Bologna, Sara, Filidei, Marta, Ravera, Enrico, Lelli, Moreno, Moda, Fabio, Fragai, Marco, Parnetti, Lucilla, Luchinat, Claudio

“…Background Aggregation of [alpha]-synuclein ([alpha]-syn) is a prominent feature of Parkinson's disease (PD) and other synucleinopathies. Currently,…”
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