Search Results - "Farrelly, Angela M"

Targeting the PI3K and MAPK pathways to improve response to HER2-targeted therapies in HER2-positive gastric cancer by Mezynski, M Janusz, Farrelly, Angela M, Cremona, Mattia, Carr, Aoife, Morgan, Clare, Workman, Julie, Armstrong, Paul, McAuley, Jennifer, Madden, Stephen, Fay, Joanna, Sheehan, Katherine M, Kay, Elaine W, Holohan, Ciara, Elamin, Yasir, Rafee, Shereen, Morris, Patrick G, Breathnach, Oscar, Grogan, Liam, Hennessy, Bryan T, Toomey, Sinead

“…Aberrant PI3K signalling is implicated in trastuzumab resistance in HER2-positive gastric cancer (GC). The role of PI3K or MEK inhibitors in sensitising…”
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Design, synthesis and evaluation of novel 2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one based chalcones as cytotoxic agents by Jean, Julie, Farrell, David S., Farrelly, Angela M., Toomey, Sinead, Barlow, James W.

“…We designed and synthesised a series of novel chalcones, incorporating the heterocyclic framework of 2,2-dimethyl-2,3-dihydro-4(1H)-quinolinone, which was…”
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Chromosomal copy number and mutational status are required to authenticate ovarian cancer cell lines as appropriate cell models by Stordal, Britta, Farrelly, Angela M., Hennessy, Bryan T.

“…Background The mutational status of ovarian cancer cell line IGROV-1 is inconsistent across the literature, suggestive of multiple clonal populations of the…”
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Proteomic time course of breast cancer cells highlights enhanced sensitivity to Stat3 and Src inhibitors prior to endocrine resistance development by Madden, Stephen F., Cremona, Mattia, Farrelly, Angela M., Low, Weng Hei, McBryan, Jean

“…To prevent the development of endocrine-resistant breast cancer, additional targeted therapies are increasingly being trialled in combination with endocrine…”
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BRCA mutations lead to XIAP overexpression and sensitise ovarian cancer to inhibitor of apoptosis (IAP) family inhibitors by Cremona, Mattia, Vandenberg, Cassandra J., Farrelly, Angela M., Madden, Stephen F., Morgan, Clare, Kalachand, Roshni, McAlpine, Jessica N., Toomey, Sinead, Huntsman, David G., Grogan, Liam, Breathnach, Oscar, Morris, Patrick, Carey, Mark S., Scott, Clare L., Hennessy, Bryan T.

“…Background We tested the hypothesis that inhibitor of apoptosis family (IAP) proteins may be altered in BRCA1 -mutated ovarian cancers and that could affect…”
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Combined Targeted Resequencing of Cytosine DNA Methylation and Mutations of DNA Repair Genes with Potential Use for Poly(ADP-Ribose) Polymerase 1 Inhibitor Sensitivity Testing by Grimm, Christina, Fischer, Axel, Farrelly, Angela M., Kalachand, Roshni, Castiglione, Roberta, Wasserburger, Elena, Hussong, Michelle, Schultheis, Anne M., Altmüller, Janine, Thiele, Holger, Reinhardt, H. Christian, Hauschulz, Kai, Hennessy, Bryan T., Herwig, Ralf, Lienhard, Matthias, Buettner, Reinhard, Schweiger, Michal R.

“…Current molecular tumor diagnostics encompass panel sequencing to detect mutations, copy number alterations, and rearrangements. However, tumor suppressor…”
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AMP-activated Protein Kinase Mediates Apoptosis in Response to Bioenergetic Stress through Activation of the Pro-apoptotic Bcl-2 Homology Domain-3-only Protein BMF by Kilbride, Seán M., Farrelly, Angela M., Bonner, Caroline, Ward, Manus W., Nyhan, Kristine C., Concannon, Caoimhín G., Wollheim, Claes B., Byrne, Maria M., Prehn, Jochen H.M.

“…Heterozygous loss-of-function mutations in the hepatocyte nuclear factor 1A (HNF1A) gene result in the pathogenesis of maturity-onset diabetes-of-the-young…”
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INS-1 Cells Undergoing Caspase-Dependent Apoptosis Enhance the Regenerative Capacity of Neighboring Cells by BONNER, Caroline, BACON, Siobhán, WOLLHEIM, Claes B, GRAF, Rolf, BYRNE, Maria M, PREHN, Jochen H. M, CONCANNON, Caoimhín G, RIZVI, Syed R, BAQUIE, Mathurin, FARRELLY, Angela M, KILBRIDE, Seán M, DUSSMANN, Heiko, WARD, Manus W, BOULANGER, Chantal M

“…In diabetes, β-cell mass is not static but in a constant process of cell death and renewal. Inactivating mutations in transcription factor 1 (tcf-1)/hepatocyte…”
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Bone Morphogenetic Protein 3 Controls Insulin Gene Expression and Is Down-regulated in INS-1 Cells Inducibly Expressing a Hepatocyte Nuclear Factor 1A–Maturity-onset Diabetes of the Young Mutation by Bonner, Caroline, Farrelly, Angela M., Concannon, Caoimhín G., Dussmann, Heiko, Baquié, Mathurin, Virard, Isabelle, Wobser, Hella, Kögel, Donat, Wollheim, Claes B., Rupnik, Marjan, Byrne, Maria M., König, Hans-Georg, Prehn, Jochen H.M.

“…Inactivating mutations in the transcription factor hepatocyte nuclear factor (HNF) 1A cause HNF1A–maturity-onset diabetes of the young (HNF1A-MODY), the most…”
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Rapamycin protects against dominant negative-HNF1A-induced apoptosis in INS-1 cells by Farrelly, Angela M., Kilbride, Seán M., Bonner, Caroline, Prehn, Jochen H. M., Byrne, Maria M.

“…HNF1A-maturity onset diabetes of the young (HNF1A-MODY) is caused by mutations in Hnf1a gene encoding the transcription factor hepatocyte nuclear factor 1alpha…”
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Chemotactic, mitogenic, and angiogenic actions of UTP on vascular endothelial cells by Satterwhite, C M, Farrelly, A M, Bradley, M E

“…Endothelial cells express receptors for ATP and UTP, and both UTP and ATP elicit endothelial release of vasoactive compounds such as prostacyclin and nitric…”
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Abstract P1-19-24: A phase Ib trial of copanlisib in combination with trastuzumab in pretreated recurrent or metastatic HER2-positive breast cancer “PantHER” by Keegan, Niamh M, Furney, Simon, Walshe, Janice, Gullo, Giuseppe, Kennedy, John, Bulger, Kyran, McCaffrey, John, Kelly, Catherine M, Egan, Keith, O'Donovan, P, Hernando, Andres, Teiserskiene, Ausra, Parker, Imelda, Farrelly, Angela M, Carr, Aoife, Calzaferri, Giulio, McDermott, Ray, Keane, Maccon M, Grogan, Liam, Breathnach, Oscar S, Morris, Patrick G, Toomey, Sinead, Hennessy, Bryan T

“…Background Activation of the phosphoinositide -3 kinase (PI3K) pathway is a resistance mechanism to anti-HER2 targeted therapy. This trial was conducted to…”
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Cloning, expression and function of Kv11.1 variants in the human jejunum by Farrelly, Angela M

“…This thesis investigates the hypothesis that the voltage dependent potassium channel Kv11.1 is present in the human jejunum and significantly contributes to…”
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