Search Results - "Farrell, J P"

Epstein–Barr virus and Burkitt lymphoma by Brady, G, MacArthur, G J, Farrell, P J

“…Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and immunodeficiency-associated variants. It has been known for many years that…”
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Association of innate immune activation with latent Epstein-Barr virus in active MS lesions by TZARTOS, J. S, KHAN, G, FARRELL, P. J, GIOVANNONI, G, MEIER, U.-C, VOSSENKAMPER, A, CRUZ-SADABA, M, LONARDI, S, SEFIA, E, MEAGER, A, ELIA, A, MIDDELDORP, J. M, CLEMENS, M

“…To determine whether the activation of innate immune responses, which can be elicited by pathogenic and endogenous triggers, is associated with the presence of…”
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The collagen prolyl hydroxylases are novel transcriptionally silenced genes in lymphoma by Hatzimichael, E, Lo Nigro, C, Lattanzio, L, Syed, N, Shah, R, Dasoula, A, Janczar, K, Vivenza, D, Monteverde, M, Merlano, M, Papoudou-Bai, A, Bai, M, Schmid, P, Stebbing, J, Bower, M, Dyer, M J S, Karran, L E, ElguetaKarstegl, C, Farrell, P J, Thompson, A, Briasoulis, E, Crook, T

“…Background: Prolyl hydroxylation is a post-translational modification that affects the structure, stability and function of proteins including collagen by…”
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The Z0011 Trial: Is this the end of axillary ultrasound in the pre-operative assessment of breast cancer patients? by Farrell, T. P. J., Adams, N. C., Stenson, M., Carroll, P. A., Griffin, M., Connolly, E. M., O’Keeffe, S. A.

“…Objectives The Z0011 trial questioned the role of axillary ultrasound (AxUS) in preoperative staging of breast cancer in patients with ≤2 positive sentinel…”
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Ultrafast X-ray Auger probing of photoexcited molecular dynamics by McFarland, B. K., Farrell, J. P., Miyabe, S., Tarantelli, F., Aguilar, A., Berrah, N., Bostedt, C., Bozek, J. D., Bucksbaum, P. H., Castagna, J. C., Coffee, R. N., Cryan, J. P., Fang, L., Feifel, R., Gaffney, K. J., Glownia, J. M., Martinez, T. J., Mucke, M., Murphy, B., Natan, A., Osipov, T., Petrović, V. S., Schorb, S., Schultz, Th, Spector, L. S., Swiggers, M., Tenney, I., Wang, S., White, J. L., White, W., Gühr, M.

“…Molecules can efficiently and selectively convert light energy into other degrees of freedom. Disentangling the underlying ultrafast motion of electrons and…”
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Epstein-Barr virus nuclear antigen (EBNA)3C is an immortalizing oncoprotein with similar properties to adenovirus E1A and papillomavirus E7 by Parker, G A, Crook, T, Bain, M, Sara, E A, Farrell, P J, Allday, M J

“…Epstein-Barr virus (EBV) requires six genes to efficiently immortalize human B cells. We have shown that one of these, EBNA3C, can cooperate with activated…”
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Epstein‐Barr virus BZLF1 trans‐activator specifically binds to a consensus AP‐1 site and is related to c‐fos by Farrell, P. J., Rowe, D. T., Rooney, C. M., Kouzarides, T.

“…Two regions of the Epstein‐Barr virus BZLF1 trans‐activator protein have sequence similarity to the c‐fos protein. Part of the similarity corresponds to the…”
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p73 is over-expressed in vulval cancer principally as the Δ2 isoform by O'NIONS, J, BROOKS, L. A, EVANS, A, GASCO, M, GUSTERSON, B, CROOK, T, SULLIVAN, A, BELL, A, DUNNE, B, ROZYCKA, M, REDDY, A, TIDY, J. A, EVANS, D, FARRELL, P. J

“…p73 was studied in squamous cancers and precursor lesions of the vulva. Over-expression of p73 occurred commonly in both human papillomavirus (HPV)-positive…”
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Analysis of CHK2 in vulval neoplasia by REDDY, A, YUILLE, M, CROOK, T, SULLIVAN, A, REPELLIN, C, BELL, A, TIDY, J. A, EVANS, D. J, FARRELL, P. J, GUSTERSON, B, GASCO, M

“…Structure and expression of the Rad53 homologue CHK2 were studied in vulval neoplasia. We identified the previously described silent polymorphism at codon 84…”
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Differences in B cell growth phenotype reflect novel patterns of Epstein‐Barr virus latent gene expression in Burkitt's lymphoma cells by Rowe, M., Rowe, D. T., Gregory, C. D., Young, L. S., Farrell, P. J., Rupani, H., Rickinson, A. B.

“…Recently established Epstein‐Barr virus (EBV)‐positive Burkitt's lymphoma (BL) cell lines, carrying chromosomal translocations indicative of their malignant…”
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Epstein-Barr virus nuclear antigen EBNA3C/6 expression maintains the level of latent membrane protein 1 in G1-arrested cells by ALLDAY, M. J, FARRELL, P. J

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E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia by BROOKS, L. A, SULLIVAN, A, FARRELL, P. J, STOREY, A, GASCO, M, SAKAI, T, CROOK, T, O'NIONS, J, BELL, A, DUNNE, B, TIDY, J. A, EVANS, D. J, OSIN, P, VOUSDEN, K. H, GUSTERSON, B

“…In common with other E2F1 responsive genes such as p14(ARF) and B-myb, the promoter of p73 is shown to be positively regulated in cell lines and primary human…”
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Epstein–Barr virus and Burkitt lymphoma by Brady, G, MacArthur, G J, Farrell, P J

“…Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and immunodeficiency-associated variants. It has been known for many years that…”
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Intravenous administration of an E1/E3-deleted adenoviral vector induces tolerance to factor IX in C57BL/6 mice by FIELDS, P. A, ARMSTRONG, E, HAGSTROM, J. N, ARRUDA, V. R, MURPHY, M. L, FARRELL, J. P, HIGH, K. A, HERZOG, R. W

“…Inbred immunocompetent C57BL/6 mice have been a favored strain to study transgene expression of human blood coagulation factor IX (hF.IX) from viral vectors…”
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Switch from a Type 2 to a Type 1 T Helper Cell Response and Cure of Established Leishmania major Infection in Mice is Induced by Combined Therapy with Interleukin 12 and Pentostam by Nabors, Gary S., Luis C. C. Afonso, Farrell, Jay P., Scott, Phillip

“…Successful treatment in allergic, autoimmune, and infectious diseases often requires altering the nature of a detrimental immune response mediated by a…”
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Probing nucleobase photoprotection with soft x-rays by McFarland, B. K., Farrell, J. P., Berrah, N., Bostedt, C., Bozek, J., Bucksbaum, P.H., Coffee, R., Cryan, J., Fang, L., Feifel, R., Gaffney, K., Glownia, J., Martinez, T., Mucke, M., Murphy, B., Miyabe, S., Natan, A., Osipov, T., Petrovic, V., Schorb, S., Schultz, Th, Spector, L., Tarantelli, F., Tenney, I., Wang, S., White, W., White, J., Gühr, M.

“…Nucleobases absorb strongly in the ultraviolet region, leading to molecular excitation into reactive states. The molecules avoid the photoreactions by…”
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Tumour viruses—could they be an Achilles' heel of cancer? by Farrell, P.J

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Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia by YOUNG, L. S, LAU, R, FARRELL, P. J, ROWE, M, NIEDOBITEK, G, PACKHAM, G, SHANAHAN, F, ROWE, D. T, GREENSPAN, D, GREENSPAN, J. S, RICKINSON, A. B

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The spliced BZLF1 gene of Epstein-Barr virus (EBV) transactivates an early EBV promoter and induces the virus productive cycle by ROONEY, C. M, ROWE, D. T, RAGOT, T, FARRELL, P. J

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High-level expression of secreted glycoproteins in transformed lepidopteran insect cells using a novel expression vector by Farrell, Patrick J., Lu, Maolong, Prevost, Jay, Brown, Chris, Behie, Leo, Iatrou, Kostas

“…An expression cassette for continuous high‐level expression of secreted glycoproteins by transformed lepidopteran insect cells has been developed as an…”
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