Search Results - "Farre, Victor"

Targeting Nrf2 in Protection Against Renal Disease by Guerrero-Hue, Melania, Farre-Alins, Victor, Palomino-Antolin, Alejandra, Parada, Esther, Rubio-Navarro, Alfonso, Egido, Jesus, Egea, Javier, Moreno, Juan A

“…Renal disease is a serious health problem, with increasing incidence and prevalence. Oxidative stress and inflammation play a key role in the pathogenesis and…”
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Early toll‐like receptor 4 blockade reduces ROS and inflammation triggered by microglial pro‐inflammatory phenotype in rodent and human brain ischaemia models by Parada, Esther, Casas, Ana I., Palomino‐Antolin, Alejandra, Gómez‐Rangel, Vanessa, Rubio‐Navarro, Alfonso, Farré‐Alins, Victor, Narros‐Fernandez, Paloma, Guerrero‐Hue, Melania, Moreno, Juan Antonio, Rosa, Juliana M., Roda, José M., Hernández‐García, Borja J., Egea, Javier

“…Background and Purpose Ischaemic stroke is a leading cause of death, disability, and a high unmet medical need. Post‐reperfusion inflammation and an…”
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Melatonin's efficacy in stroke patients; a matter of dose? A systematic review by Ramos, Eva, Farré-Alins, Víctor, Egea, Javier, López-Muñoz, Francisco, Reiter, Russel J., Romero, Alejandro

“…There is a lack of effective therapies for stroke patients; its treatment is even more difficult considering the unexpected onset of the disease. In the last…”
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Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices by Patiño, Paloma, Parada, Esther, Farré-Alins, Victor, Molz, Simone, Cacabelos, Ramón, Marco-Contelles, José, López, Manuela G., Tasca, Carla I., Ramos, Eva, Romero, Alejandro, Egea, Javier

“…•Melatonin decreased cell death of hippocampal slices subjected to OGD/Reox.•Melatonin reduced superoxide anion, main source of ROS generation during…”
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Activation of NLRP3 Is Required for a Functional and Beneficial Microglia Response after Brain Trauma by Lopez-Rodriguez, Ana Belen, Decouty-Perez, Céline, Farré-Alins, Victor, Palomino-Antolín, Alejandra, Narros-Fernández, Paloma, Egea, Javier

“…Despite the numerous research studies on traumatic brain injury (TBI), many physiopathologic mechanisms remain unknown. TBI is a complex process, in which…”
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In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases by Więckowska, Anna, Szałaj, Natalia, Góral, Izabella, Bucki, Adam, Latacz, Gniewomir, Kiec-Kononowicz, Katarzyna, Bautista-Aguilera, Òscar. M, Romero, Alejandro, Ramos, Eva, Egea, Javier, Farré Alíns, Victor, González-Rodríguez, Águeda, López-Muñoz, Francisco, Chioua, Mourad, Marco-Contelles, José

“…Herein we report in vitro metabolic stability in human liver microsomes (HLMs), interactions with cytochrome P450 isoenzymes (CYP3A4, CYP2D6, and CYP2C9), and…”
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Neuroprotective effects of E‐PodoFavalin‐15999 (Atremorine®) by Romero, Alejandro, Parada, Esther, González‐Lafuente, Laura, Farré‐Alins, Victor, Ramos, Eva, Cacabelos, Ramón, Egea, Javier

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TLR4 pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury by Rosa, Juliana M., Farré‐Alins, Víctor, Ortega, María Cristina, Navarrete, Marta, Lopez‐Rodriguez, Ana Belen, Palomino‐Antolín, Alejandra, Fernández‐López, Elena, Vila‐del Sol, Virginia, Decouty, Céline, Narros‐Fernández, Paloma, Clemente, Diego, Egea, Javier

“…Background and Purpose Activation of astrocytes contributes to synaptic remodelling, tissue repair and neuronal survival following traumatic brain injury…”
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Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis‐mediated cell death by Guerrero‐Hue, Melania, García‐Caballero, Cristina, Palomino‐Antolín, Alejandra, Rubio‐Navarro, Alfonso, Vázquez‐Carballo, Cristina, Herencia, Carmen, Martín‐Sanchez, Diego, Farré‐Alins, Víctor, Egea, Javier, Cannata, Pablo, Praga, Manuel, Ortiz, Alberto, Egido, Jesús, Sanz, Ana Belén, Moreno, Juan Antonio

“…ABSTRACT Acute kidney injury is a common complication of rhabdomyolysis. A better understanding of this syndrome may be useful to identify novel therapeutic…”
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Alternative to In Vivo Tests During the COVID-19 Pandemic: Multiple Allergen Simultaneous Tests as a Useful First Screening by Bartolome, Clara San, Farre, Victor, Rius, Josefina, Torradeflot, Maria, Espanol-Rego, Marta, Pascal, Mariona

“…In allergy diagnosis we sometimes find some clinical or logistic limitations to be able to carry out in vivo tests, so the detection of serum allergic-specific…”
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Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases by Bautista‐Aguilera, Óscar M., Hagenow, Stefanie, Palomino‐Antolin, Alejandra, Farré‐Alins, Víctor, Ismaili, Lhassane, Joffrin, Pierre‐Louis, Jimeno, María L., Soukup, Ondřej, Janočková, Jana, Kalinowsky, Lena, Proschak, Ewgenij, Iriepa, Isabel, Moraleda, Ignacio, Schwed, Johannes S., Romero Martínez, Alejandro, López‐Muñoz, Francisco, Chioua, Mourad, Egea, Javier, Ramsay, Rona R., Marco‐Contelles, José, Stark, Holger

“…The therapy of complex neurodegenerative diseases requires the development of multitarget‐directed drugs (MTDs). Novel indole derivatives with inhibitory…”
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Time‐dependent dual effect of NLRP3 inflammasome in brain ischaemia by Palomino‐Antolin, Alejandra, Narros‐Fernández, Paloma, Farré‐Alins, Víctor, Sevilla‐Montero, Javier, Decouty‐Pérez, Celine, Lopez‐Rodriguez, Ana Belen, Fernández, Nuria, Monge, Luis, Casas, Ana I., Calzada, María José, Egea, Javier

“…Background Inflammasomes are cytosolic multiprotein complexes which, upon assembly, activate the maturation and secretion of the inflammatory cytokines IL‐1β…”
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Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux by Farré-Alins, Víctor, Narros-Fernández, Paloma, Palomino-Antolín, Alejandra, Decouty-Pérez, Céline, Lopez-Rodriguez, Ana Belen, Parada, Esther, Muñoz-Montero, Alicia, Gómez-Rangel, Vanessa, López-Muñoz, Francisco, Ramos, Eva, González-Rodríguez, Águeda, Gandía, Luis, Romero, Alejandro, Egea, Javier

“…Microglia controls the immune system response in the brain. Specifically, the activation and dysregulation of the NLRP3 inflammasome is responsible for the…”
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Randomized controlled trial on healthy volunteers of pharmacokinetic and antimicrobial activity of a novel hydrogel-containing chlorhexidine dressing to prevent catheter-related bloodstream infection by Masferrer, Emili, Riera-Rodríguez, Laura, Farré-Alins, Víctor, Vilà de Muga, Sandra, Arroyo-Muñoz, Francisco-Javier, González-Caro, María-Dolores

“…Catheter-related blood stream infection (CRBSI) is one of the most relevant complications associated to the use of intravascular catheters. In this context,…”
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Evolución 2001-2018 de los niveles de colesterol sérico en una población de Cataluña (Osona, Barcelona) by Deniel Rosanas, Joan, Prat Quinzaños, Jordi, Roura Poch, Pere, Casas Capdevila, Maria-Àngels, Farré Guerrero, Victor

“…Estudiar la evolución del nivel sérico de colesterol de una población en un intervalo de tiempo de 18 años (2001-2018). Atención primaria y especialidades…”
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Redox Regulation of Microglial Inflammatory Response: Fine Control of NLRP3 Inflammasome through Nrf2 and NOX4 by Palomino-Antolín, Alejandra, Decouty-Pérez, Céline, Farré-Alins, Víctor, Narros-Fernández, Paloma, Lopez-Rodriguez, Ana Belen, Álvarez-Rubal, María, Valencia, Inés, López-Muñoz, Francisco, Ramos, Eva, Cuadrado, Antonio, Casas, Ana I, Romero, Alejandro, Egea, Javier

“…The role of inflammation and immunity in the pathomechanism of neurodegenerative diseases has become increasingly relevant within the past few years. In this…”
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Synthesis and Pharmacological Evaluation of New N‑Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout by Narros-Fernández, Paloma, Chioua, Mourad, Petcu, Sonia A, Diez-Iriepa, Daniel, Cerrada-Gálvez, Laura, Decouty-Pérez, Céline, Palomino-Antolín, Alejandra, Ramos, Eva, Farré-Alins, Víctor, López-Rodríguez, Ana Belén, Romero, Alejandro, Marco-Contelles, José, Egea, Javier

“…NLRP3 is involved in the pathophysiology of several inflammatory diseases. Therefore, there is high current interest in the clinical development of new NLRP3…”
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Effectiveness of different methods for anti-Sm antibody identification. A multicentre study by Llorente, María Jesús, Jiménez, Juana, González, Concepción, Alarcón, Inmaculada, Alsina, Monserrat, Casas, Luisa María, Benedito, José Enrique, Luis Araquistain, José, Farre, Victor, González-Buitrago, José Manuel

“…Methods for the measurement of autoantibodies frequently provide controversial results. The objective of the present study was to evaluate the performance of…”
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Multipotente Liganden mit kombinierter Cholinesterase‐ und Monoaminooxidase‐Inhibition sowie Histamin‐H3R‐Antagonismus bei neurodegenerativen Erkrankungen by Bautista‐Aguilera, Óscar M., Hagenow, Stefanie, Palomino‐Antolin, Alejandra, Farré‐Alins, Víctor, Ismaili, Lhassane, Joffrin, Pierre‐Louis, Jimeno, María L., Soukup, Ondřej, Janočková, Jana, Kalinowsky, Lena, Proschak, Ewgenij, Iriepa, Isabel, Moraleda, Ignacio, Schwed, Johannes S., Romero Martínez, Alejandro, López‐Muñoz, Francisco, Chioua, Mourad, Egea, Javier, Ramsay, Rona R., Marco‐Contelles, José, Stark, Holger

“…Die Therapie von komplexen neurodegenerativen Erkrankungen erfordert eine Entwicklung von Multitarget‐orientierten Wirkstoffen. Durch strukturelle Optimierung…”
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Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H 3 R Antagonism for Neurodegenerative Diseases by Bautista-Aguilera, Óscar M, Hagenow, Stefanie, Palomino-Antolin, Alejandra, Farré-Alins, Víctor, Ismaili, Lhassane, Joffrin, Pierre-Louis, Jimeno, María L, Soukup, Ondřej, Janočková, Jana, Kalinowsky, Lena, Proschak, Ewgenij, Iriepa, Isabel, Moraleda, Ignacio, Schwed, Johannes S, Romero Martínez, Alejandro, López-Muñoz, Francisco, Chioua, Mourad, Egea, Javier, Ramsay, Rona R, Marco-Contelles, José, Stark, Holger

“…The therapy of complex neurodegenerative diseases requires the development of multitarget-directed drugs (MTDs). Novel indole derivatives with inhibitory…”
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