Patterns of Host Genome—Wide Gene Transcript Abundance in the Peripheral Blood of Patients with Acute Dengue Hemorrhagic Fever

Responses by peripheral blood leukocytes may contribute to the pathogenesis of dengue hemorrhagic fever (DHF). We used DNA microarrays to reveal transcriptional patterns in the blood of 14 adults with DHF. Acute DHF was defined by an abundance of transcripts from cell cycle— and endoplasmic reticulu...

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Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 195; no. 8; pp. 1097 - 1107
Main Authors:	Simmons, Cameron P., Popper, Stephen, Dolocek, Christiane, Chau, Tran Nguyen Bich, Griffiths, Michael, Dung, Nguyen Thi Phuong, Long, Troung Hoang, Hoang, Dang Minh, Chau, Nguyen Vinh, Thao, Le Thi Thu, Hien, Tran Tinh, Relman, David A., Farrar, Jerremy
Format:	Journal Article
Language:	English
Published:	Chicago, IL The University of Chicago Press 15-04-2007 University of Chicago Press
Subjects:	Acute Disease Adolescent Adult B lymphocytes B-Lymphocytes - immunology B-Lymphocytes - virology Biological and medical sciences Blood CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell cycle Child Convalescence Cytokines - genetics Dengue Dengue hemorrhagic fever Dengue virus Dengue Virus - genetics Dengue Virus - immunology Dengue Virus - physiology Diseases DNA Primers - chemistry Female Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Viral - physiology Genes Genes, cdc - physiology Humans Infections Infectious diseases Major and Brief Reports Male Medical sciences Microbiology Multigene Family - genetics Oligonucleotide Array Sequence Analysis - methods RNA, Messenger - blood RNA, Viral - blood Severe Dengue - immunology Severe Dengue - virology Transcription, Genetic Vietnam Viruses Vietnam Human Hemorrhagic fever Dengue hemorrhagic fever Microbiology Dengue Acute Peripheral blood circulation Infection Messenger RNA Gene Viral disease Arbovirus disease Genome
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Summary:	Responses by peripheral blood leukocytes may contribute to the pathogenesis of dengue hemorrhagic fever (DHF). We used DNA microarrays to reveal transcriptional patterns in the blood of 14 adults with DHF. Acute DHF was defined by an abundance of transcripts from cell cycle— and endoplasmic reticulum (ER)—related genes, suggesting a proliferative response accompanied by ER stress. Transcript-abundance levels for immunoresponse-associated genes, including cell surface markers, immunoglobulin, and innate response elements, were also elevated. Twenty-four genes were identified for which transcript abundance distinguished patients with dengue shock syndrome (DSS) from those without DSS. All the gene transcripts associated with DSS, many of which are induced by type I interferons, were less abundant in patients with DSS than in those without DSS. To our knowledge, these data provide the first snapshot of gene-expression patterns in peripheral blood during acute dengue and suggest that DSS is associated with attenuation of selected aspects of the innate host response.
Bibliography:	Both authors contributed equally to this work. istex:6D509DEE7E2ABB7AF383D8A1BE7C92EFDD8CE820 ark:/67375/HXZ-9WV7BF1D-B ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-1899 1537-6613
DOI:	10.1086/512162