Search Results - "Farrar, Conrad A"

Rationale for targeting complement in COVID‐19 by Polycarpou, Anastasia, Howard, Mark, Farrar, Conrad A, Greenlaw, Roseanna, Fanelli, Giorgia, Wallis, Russell, Klavinskis, Linda S, Sacks, Steven

“…A novel coronavirus, SARS‐CoV‐2, has recently emerged in China and spread internationally, posing a health emergency to the global community. COVID‐19 caused…”
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Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury by Farrar, Conrad A, Tran, David, Li, Ke, Wu, Weiju, Peng, Qi, Schwaeble, Wilhelm, Zhou, Wuding, Sacks, Steven H

“…Physiochemical stress induces tissue injury as a result of the detection of abnormal molecular patterns by sensory molecules of the innate immune system. Here,…”
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Collectin-11 Promotes the Development of Renal Tubulointerstitial Fibrosis by Wu, Weiju, Liu, Chengfei, Farrar, Conrad A, Ma, Liang, Dong, Xia, Sacks, Steven H, Li, Ke, Zhou, Wuding

“…Collectin-11 is a recently described soluble C-type lectin, a pattern recognition molecule of the innate immune system that has distinct roles in host defense,…”
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Mannan‐binding lectin‐associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4 by Asgari, Elham, Farrar, Conrad A., Lynch, Nicholas, Ali, Youssif M., Roscher, Silke, Stover, Cordula, Zhou, Wuding, Schwaeble, Wilhelm J., Sacks, Steven H.

“…Mannan‐binding lectin‐associated serine protease 2 (MASP‐2) has been described as the essential enzyme for the lectin pathway (LP) of complement activation…”
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Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury by Schwaeble, Wilhelm J, Lynch, Nicholas J, Clark, James E, Marber, Michael, Samani, Nilesh J, Ali, Youssif Mohammed, Dudler, Thomas, Parent, Brian, Lhotta, Karl, Wallis, Russell, Farrar, Conrad A, Sacks, Steven, Lee, Haekyung, Zhang, Ming, Iwaki, Daisuke, Takahashi, Minoru, Fujita, Teizo, Tedford, Clark E, Stover, Cordula M

“…Complement research experienced a renaissance with the discovery of a third activation route, the lectin pathway. We developed a unique model of total lectin…”
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Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia‐reperfusion injury by Farrar, Conrad A., Keogh, Brian, McCormack, William, O'Shaughnessy, Aisling, Parker, Andrew, Reilly, Mary, Sacks, Steven H.

“…ABSTRACT Toll‐like receptors (TLRs) are important molecules involved in the activation of innate and subsequent development of adaptive immunity. TLRs are…”
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Local extravascular pool of C3 is a determinant of postischemic acute renal failure by Farrar, Conrad A., Zhou, Wuding, Lin, Tao, Sacks, Steven H.

“…ABSTRACT The third complement component (C3) is an acute phase protein that plays a central role in reperfusion injury in several organ models. To investigate…”
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Collectin-11 (CL-11) Is a Major Sentinel at Epithelial Surfaces and Key Pattern Recognition Molecule in Complement-Mediated Ischaemic Injury by Nauser, Christopher L, Howard, Mark C, Fanelli, Giorgia, Farrar, Conrad A, Sacks, Steven

“…The complement system is a dynamic subset of the innate immune system, playing roles in host defense, clearance of immune complexes and cell debris, and…”
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Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a–C3aR interaction by Peng, Qi, Li, Ke, Anderson, Katie, Farrar, Conrad A., Lu, Bao, Smith, Richard A.G., Sacks, Steven H., Zhou, Wuding

“…Donor cell expression of C3 enhances the alloimmune response and is associated with the fate of transplantation. To clarify the mechanism for enhancement of…”
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Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress by Fanelli, Giorgia, Gonzalez-Cordero, Anai, Gardner, Peter J., Peng, Qi, Fernando, Milan, Kloc, Magdalena, Farrar, Conrad A., Naeem, Arifa, Garred, Peter, Ali, Robin R., Sacks, Steven H.

“…Age-related macular degeneration (AMD) is a major cause of blindness and is associated with complement dysregulation. The disease is a potential target for…”
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Deficiency of C5aR Prolongs Renal Allograft Survival by QIJUN LI, QI PENG, GUOLAN XING, KE LI, NAIYIN WANG, FARRAR, Conrad A, MEADER, Lucy, SACKS, Steven H, WUDING ZHOU

“…Interaction between C5a, a product of complement activation, and its receptor (C5aR) upregulates antigen-specific T cell responses by modulating the activation…”
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Complement Recognition Pathways in Renal Transplantation by Nauser, Christopher L, Farrar, Conrad A, Sacks, Steven H

“…The complement system, consisting of soluble and cell membrane-bound components of the innate immune system, has defined roles in the pathophysiology of renal…”
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Structural and functional diversity of collectins and ficolins and their relationship to disease by Howard, Mark, Farrar, Conrad A., Sacks, Steven H.

“…Pattern recognition molecules are sensors for the innate immune system and trigger a number of pathophysiological functions after interaction with the…”
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Complement in ischaemia–reperfusion injury and transplantation by Howard, Mark C., Nauser, Christopher L., Farrar, Conrad A., Sacks, Steven H.

“…Until recently, the only known condition in which complement could mediate transplant injury was the rare occurrence of antibody-mediated rejection, in which…”
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l‐Fucose prevention of renal ischaemia/reperfusion injury in Mice by Howard, Mark C., Nauser, Christopher L., Farrar, Conrad A., Wallis, Russell, Sacks, Steven H.

“…In a recent study, we identified a fucosylated damage‐associated ligand exposed by ischemia on renal tubule epithelial cells, which after recognition by…”
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The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis by Choudhry, Naheed, Li, Ke, Zhang, Ting, Wu, Kun-Yi, Song, Yun, Farrar, Conrad A, Wang, Na, Liu, Cheng-Fei, Peng, Qi, Wu, Weiju, Sacks, Steven H, Zhou, Wuding

“…Complement factor 5a (C5a) interaction with its receptor (C5aR1) contributes to the pathogenesis of inflammatory diseases, including acute kidney injury…”
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Deficiency of C4 from Donor or Recipient Mouse Fails to Prevent Renal Allograft Rejection by Lin, Tao, Zhou, Wuding, Farrar, Conrad A., Hargreaves, Roseanna E.G., Sheerin, Neil S., Sacks, Steven H.

“…Complement effector products generated in the transplanted kidney are known to mediate transplant rejection, but which of the three main activation pathways of…”
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Role of the lectin complement pathway in kidney transplantation by Farrar, Conrad A, Zhou, Wuding, Sacks, Steven H

“…Abstract In the last 15 years two major advances in the role of complement in the kidney transplant have come about. The first is that ischaemia reperfusion…”
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Correction to: Complement in ischaemia–reperfusion injury and transplantation by Howard, Mark C., Nauser, Christopher L., Farrar, Conrad A., Sacks, Steven H.

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C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli by Li, Ke, Wu, Kun-Yi, Wu, Weiju, Wang, Na, Zhang, Ting, Choudhry, Naheed, Song, Yun, Farrar, Conrad A, Ma, Liang, Wei, Lin-Lin, Duan, Zhao-Yang, Dong, Xia, Liu, En-Qi, Li, Zong-Fang, Sacks, Steven H, Zhou, Wuding

“…C5a receptor 1 (C5aR1) is a G protein-coupled receptor for C5a and also an N-linked glycosylated protein. In addition to myeloid cells, C5aR1 is expressed on…”
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