Search Results - "Farrant, R. Duncan"

Metabonomic Deconvolution Of Embedded Toxicity:  Application To Thioacetamide Hepato- and Nephrotoxicity by Waters, Nigel J, Waterfield, Catherine J, Farrant, R. Duncan, Holmes, Elaine, Nicholson, Jeremy K

“…We present here the potential of an integrated metabonomic strategy to deconvolute the biofluid metabolic signatures in experimental animals following multiple…”
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Integrated Metabonomic Analysis of Bromobenzene-Induced Hepatotoxicity:  Novel Induction of 5-Oxoprolinosis by Waters, Nigel J, Waterfield, Catherine J, Farrant, R. Duncan, Holmes, Elaine, Nicholson, Jeremy K

“…We present here a definitive metabonomic analysis in order to detect novel biomarker and metabolite information, implicating specific putative protein targets…”
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NMR and pattern recognition studies on liver extracts and intact livers from rats treated with α-naphthylisothiocyanate by Waters, Nigel J, Holmes, Elaine, Waterfield, Catherine J, Farrant, R.Duncan, Nicholson, Jeremy K

“…The metabolite profiles from livers of toxin-treated rats were investigated using high resolution 1 H NMR spectroscopy of aqueous (acetonitrile/water), lipidic…”
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NMR and Pattern Recognition Studies on the Time-Related Metabolic Effects of α-Naphthylisothiocyanate on Liver, Urine, and Plasma in the Rat:  An Integrative Metabonomic Approach by Waters, Nigel J, Holmes, Elaine, Williams, Ann, Waterfield, Catherine J, Farrant, R. Duncan, Nicholson, Jeremy K

“…We present here a novel integrative metabonomic approach to probe toxic effects of drugs in experimental animals using α-naphthylisothiocyanate (ANIT) as a…”
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Identification of the Positional Isomers of 2-Fluorobenzoic acid 1-O-Acyl Glucuronide by Directly Coupled HPLC-NMR by Sidelmann, Ulla G, Gavaghan, Claire, Carless, Howard A. J, Farrant, R. Duncan, Lindon, John C, Wilson, Ian D, Nicholson, Jeremy K

“…Directly coupled HPLC-1H NMR was used in the "stop-flow" mode to separate and rapidly identify an equilibrated mixture of esther glucuronide isomers formed…”
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NMR and HPLC-NMR spectroscopic studies of futile deacetylation in paracetamol metabolites in rat and man by Nicholls, Andrew W, Duncan Farrant, R, Shockcor, John P, Unger, Steve E, Wilson, Ian D, Lindon, John C, Nicholson, Jeremy K

“…HPLC-NMR spectroscopy has been used to investigate the level of deacetylation followed by reacetylation (futile deacetylation) of metabolites of paracetamol…”
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Discovery of 4-[3-(trans-3-Dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]- (4S)-oxazolidin-2-one (4991W93), a 5HT1B/1D Receptor Partial Agonist and a Potent Inhibitor of Electrically Induced Plasma Extravasation by Jandu, Karamjit Singh, Barrett, Vikki, Brockwell, Michael, Cambridge, David, Farrant, Duncan R, Foster, Christopher, Giles, Heather, Glen, Robert C, Hill, Alan P, Hobbs, Heather, Honey, Andrew, Martin, Graeme R, Salmon, John, Smith, Donna, Woollard, Patrick, Selwood, David L

“…Utilizing a pharmacophoric model of binding of 3-(2-aminoethyl)indoles to 5HT1B/1D receptors, we identified the 3-aminocyclobutyl group as a potential…”
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750 MHz 1H and 1H-13C NMR Spectroscopy of Human Blood Plasma by Nicholson, Jeremy K, Foxall, Peta J. D, Spraul, Manfred, Farrant, R. Duncan, Lindon, John C

“…High-resolution 750 MHz 1H NMR spectra of control human blood plasma have been measured and assigned by the concerted use of a range of spin-echo,…”
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Internal temperature calibration for 1H NMR spectroscopy studies of blood plasma and other biofluids by Farrant, R D, Lindon, J C, Nicholson, J K

“…A method for temperature calibration of human blood plasma and cerebrospinal fluid (CSF) samples inside a high resolution NMR spectrometer is presented. This…”
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A novel pyrroline-5-carboxylic acid and acetoacetic acid adduct in hyperprolinaemia type II by Walker, Valerie, Mills, Graham A, Mellor, John M, Langley, G.John, Farrant, R.Duncan

“…Background: From investigations of a child with hyperprolinaemia type II, we demonstrated in vitro that pyridoxal phosphate forms a novel adduct with a proline…”
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Pyridoxal Phosphate De-activation by Pyrroline-5-carboxylic Acid by Farrant, R. Duncan, Walker, Valerie, Mills, Graham A., Mellor, John M., Langley, G. John

“…We previously identified vitamin B6 deficiency in a child presenting with seizures whose primary diagnosis was the inherited disorder hyperprolinemia type II…”
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Measurement of Internal Acyl Migration Reaction Kinetics Using Directly Coupled HPLC−NMR:  Application for the Positional Isomers of Synthetic (2-Fluorobenzoyl)-d-glucopyranuronic Acid by Sidelmann, Ulla G., Hansen, Steen H., Gavaghan, Claire, Carless, Howard A. J., Lindon, John C., Farrant, R. Duncan, Wilson, Ian D., Nicholson, Jeremy K.

“…Ester glucuronides (1-O-acyl-β-d-glucopyranuronates) of many drugs may undergo internal acyl migration reactions, resulting in the formation of new positional…”
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NMR Spectroscopic and Theoretical Chemistry Studies on the Internal Acyl Migration Reactions of the 1-O-Acyl-β-d-glucopyranuronate Conjugates of 2-, 3-, and 4-(Trifluoromethyl)benzoic Acids by Nicholls, Andrew W, Akira, Kazuki, Lindon, John C, Farrant, R. Duncan, Wilson, Ian D, Harding, John, Killick, David A, Nicholson, Jeremy K

“…High resolution 19F NMR spectroscopy has been used to investigate the kinetics of internal acyl migration and hydrolysis of the synthetic…”
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Pyridoxal phosphate de-activation by pyrroline-5-carboxylic acid. Increased risk of vitamin B6 deficiency and seizures in hyperprolinemia type II by Farrant, R D, Walker, V, Mills, G A, Mellor, J M, Langley, G J

“…We previously identified vitamin B6 deficiency in a child presenting with seizures whose primary diagnosis was the inherited disorder hyperprolinemia type II…”
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Metabonomic Investigations into Hydrazine Toxicity in the Rat by Nicholls, Andrew W, Holmes, Elaine, Lindon, John C, Shockcor, John P, Farrant, R. Duncan, Haselden, John N, Damment, Stephen J. P, Waterfield, Catherine J, Nicholson, Jeremy K

“…The systemic biochemical effects of oral hydrazine administration (dosed at 75, 90, and 120 mg/kg) have been investigated in male Han Wistar rats using…”
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Synthesis of an external β-turn based on the GLDV motif of cell adhesion proteins by Davies, David E., Doyle, Paul M., Farrant, R.Duncan, Hill, Richard D., Hitchcock, Peter B., Sanderson, Paul N., Young, Douglas W.

“…The (3 S,6 S,10 S)-7/5 bicyclic lactam 4 , designed as an external turn constraint, was synthesised by a new stereoselective route involving Eschenmoser…”
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Measurement of longitudinal relaxation times in crowded 1H NMR spectra using one- and two-dimensional maximum quantum (MAXY) NMR spectroscopy by LIU, MAILI, YE, CHAOHUI, FARRANT, R. DUNCAN, NICHOLSON, JEREMY K., LINDON, JOHN C.

“…Methods for measuring longitudinal relaxation times of protons in heavily overlapped 1 H NMR spectra are introduced and exemplified using a solution of…”
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Measurement of longitudinal relaxation times in crowded 1 H NMR spectra using one- and two-dimensional maximum quantum (MAXY) NMR spectroscopy by LIU, MAILI, YE, CHAOHUI, FARRANT, R. DUNCAN, NICHOLSON, JEREMY K., LINDON, JOHN C.

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Discovery of 4-[3-( trans -3-Dimethylaminocyclobutyl)-1 H -indol-5-ylmethyl]- (4 S )-oxazolidin-2-one (4991W93), a 5HT 1B/1D Receptor Partial Agonist and a Potent Inhibitor of Electrically Induced Plasma Extravasation by Jandu, Karamjit Singh, Barrett, Vikki, Brockwell, Michael, Cambridge, David, Farrant, Duncan R., Foster, Christopher, Giles, Heather, Glen, Robert C., Hill, Alan P., Hobbs, Heather, Honey, Andrew, Martin, Graeme R., Salmon, John, Smith, Donna, Woollard, Patrick, Selwood, David L.

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Directly-coupled HPLC-NMR spectroscopic studies of metabolism and futile deacetylation of phenacetin in the rat by Nicholls, Andrew W, Lindon, John C, Farrant, R.Duncan, Shockcor, John P, Wilson, Ian D, Nicholson, Jeremy K

“…The metabolism and futile deacetylation of phenacetin has been investigated in the rat via 1H NMR spectroscopic analysis of urine. Animals were dosed with…”
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