Search Results - "Farran, Chadi A. EL"

Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells by Yang, Bin Xia, EL Farran, Chadi A., Guo, Hong Chao, Yu, Tao, Fang, Hai Tong, Wang, Hao Fei, Schlesinger, Sharon, Seah, Yu Fen Samantha, Goh, Germaine Yen Lin, Neo, Suat Peng, Li, Yinghui, Lorincz, Matthew C., Tergaonkar, Vinay, Lim, Tit-Meng, Chen, Lingyi, Gunaratne, Jayantha, Collins, James J., Goff, Stephen P., Daley, George Q., Li, Hu, Bard, Frederic A., Loh, Yuin-Han

“…Embryonic stem cells (ESCs) repress the expression of exogenous proviruses and endogenous retroviruses (ERVs). Here, we systematically dissected the cellular…”
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Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges by Seah, Yu Fen Samantha, El Farran, Chadi A, Warrier, Tushar, Xu, Jian, Loh, Yuin-Han

“…Embryonic stem cells (ESCs) are chiefly characterized by their ability to self-renew and to differentiate into any cell type derived from the three main germ…”
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Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors by Cheng, Hui, Ang, Heather Yin-Kuan, A. EL Farran, Chadi, Li, Pin, Fang, Hai Tong, Liu, Tong Ming, Kong, Say Li, Chin, Michael Lingzi, Ling, Wei Yin, Lim, Edwin Kok Hao, Li, Hu, Huber, Tara, Loh, Kyle M., Loh, Yuin-Han, Lim, Bing

“…Recent efforts have attempted to convert non-blood cells into hematopoietic stem cells (HSCs) with the goal of generating blood lineages de novo . Here we show…”
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Chromatin complex dependencies reveal targeting opportunities in leukemia by Najm, Fadi J., DeWeirdt, Peter, Moore, Molly M., Bevill, Samantha M., El Farran, Chadi A., Macias, Kevin A., Hegde, Mudra, Waterbury, Amanda L., Liau, Brian B., van Galen, Peter, Doench, John G., Bernstein, Bradley E.

“…Chromatin regulators are frequently mutated in human cancer and are attractive drug targets. They include diverse proteins that share functional domains and…”
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RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming by Toh, Cheng-Xu Delon, Chan, Jun-Wei, Chong, Zheng-Shan, Wang, Hao Fei, Guo, Hong Chao, Satapathy, Sandeep, Ma, Dongrui, Goh, Germaine Yen Lin, Khattar, Ekta, Yang, Lin, Tergaonkar, Vinay, Chang, Young-Tae, Collins, James J., Daley, George Q., Wee, Keng Boon, Farran, Chadi A. EL, Li, Hu, Lim, Yoon-Pin, Bard, Frederic A., Loh, Yuin-Han

“…Incomplete knowledge of the mechanisms at work continues to hamper efforts to maximize reprogramming efficiency. Here, we present a systematic genome-wide RNAi…”
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RING1B O-GlcNAcylation regulates gene targeting of polycomb repressive complex 1 in human embryonic stem cells by Maury, Julien Jean Pierre, EL Farran, Chadi A., Ng, Daniel, Loh, Yuin-Han, Bi, Xuezhi, Bardor, Muriel, Choo, Andre Boon-Hwa

“…O-linked-N-acetylglucosamine (O-GlcNAc) post-translationally modifies and regulates thousands of proteins involved in various cellular mechanisms. Recently,…”
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Global H3.3 dynamic deposition defines its bimodal role in cell fate transition by Fang, Hai-Tong, EL Farran, Chadi A., Xing, Qiao Rui, Zhang, Li-Feng, Li, Hu, Lim, Bing, Loh, Yuin-Han

“…H3.3 is a histone variant, which is deposited on genebodies and regulatory elements, by Hira, marking active transcription. Moreover, H3.3 is deposited on…”
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Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations by Miller, Tyler E., Lareau, Caleb A., Verga, Julia A., DePasquale, Erica A. K., Liu, Vincent, Ssozi, Daniel, Sandor, Katalin, Yin, Yajie, Ludwig, Leif S., El Farran, Chadi A., Morgan, Duncan M., Satpathy, Ansuman T., Griffin, Gabriel K., Lane, Andrew A., Love, J. Christopher, Bernstein, Bradley E., Sankaran, Vijay G., van Galen, Peter

“…The combination of single-cell transcriptomics with mitochondrial DNA variant detection can be used to establish lineage relationships in primary human cells,…”
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Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility by Xing, Qiao Rui, Farran, Chadi A El, Zeng, Ying Ying, Yi, Yao, Warrier, Tushar, Gautam, Pradeep, Collins, James J, Xu, Jian, Dröge, Peter, Koh, Cheng-Gee, Li, Hu, Zhang, Li-Feng, Loh, Yuin-Han

“…Joint profiling of transcriptome and chromatin accessibility within single cells allows for the deconstruction of the complex relationship between…”
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Dissection of a CTCF topological boundary uncovers principles of enhancer-oncogene regulation by Kim, Kyung Lock, Rahme, Gilbert J, Goel, Viraat Y, El Farran, Chadi A, Hansen, Anders S, Bernstein, Bradley E

“…Enhancer-gene communication is dependent on topologically associating domains (TADs) and boundaries enforced by the CCCTC-binding factor (CTCF) insulator, but…”
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Impact of supraphysiologic MDM2 expression on chromatin networks and therapeutic responses in sarcoma by Bevill, Samantha M., Casaní-Galdón, Salvador, El Farran, Chadi A., Cytrynbaum, Eli G., Macias, Kevin A., Oldeman, Sylvie E., Oliveira, Kayla J., Moore, Molly M., Hegazi, Esmat, Adriaens, Carmen, Najm, Fadi J., Demetri, George D., Cohen, Sonia, Mullen, John T., Riggi, Nicolò, Johnstone, Sarah E., Bernstein, Bradley E.

“…Amplification of MDM2 on supernumerary chromosomes is a common mechanism of P53 inactivation across tumors. Here, we investigated the impact of MDM2…”
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Mitochondrial variant enrichment from high-throughput single-cell RNA-seq resolves clonal populations by Miller, Tyler E., Lareau, Caleb A., Verga, Julia A., DePasquale, Erica A.K., Liu, Vincent, Ssozi, Daniel, Sandor, Katalin, Yin, Yajie, Ludwig, Leif S., El Farran, Chadi A., Morgan, Duncan M., Satpathy, Ansuman T., Griffin, Gabriel K., Lane, Andrew A., Love, J. Christopher, Bernstein, Bradley E., Sankaran, Vijay G., van Galen, Peter

“…Combining single-cell transcriptomics with mitochondrial DNA (mtDNA) variant detection can be used to establish lineage relationships in primary human cells,…”
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Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility by Xing, Qiao Rui, El Farran, Chadi A, Zeng, Ying Zeng, Yi, Yao, Warrier, Tushar, Gautam, Pradeep, Collins, James J, Xu, Jian, Dröge, Peter, Koh, Cheng-Gee, Li, Hu, Zhang, Li-Feng, Loh, Yuin-Han

“…Joint profiling of transcriptome and chromatin accessibility within single cells allows for the deconstruction of the complex relationship between…”
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Diversification of reprogramming trajectories revealed by parallel single-cell transcriptome and chromatin accessibility sequencing by Xing, Q R, El Farran, Chadi A, Gautam, Pradeep, Chuah, Yu Song, Warrier, Tushar, Toh, Cheng-Xu Delon, Kang, Nam-Young, Sugii, Shigeki, Chang, Young-Tae, Xu, Jian, Collins, James J, Daley, George Q, Li, Hu, Zhang, Li-Feng, Loh, Yuin-Han

“…Cellular reprogramming suffers from low efficiency especially for the human cells. To deconstruct the heterogeneity and unravel the mechanisms for successful…”
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