Search Results - "Farr, Susan A."

The role of amyloid-beta in the regulation of memory by Morley, John E., Farr, Susan A.

“…In this review there is evidence that amyloid-beta peptide is a memory enhancer at physiological (picomolar) concentrations. Pathological overproduction of…”
Get full text

The SAMP8 mouse: a model to develop therapeutic interventions for Alzheimer's disease by Morley, John E, Farr, Susan A, Kumar, Vijaya B, Armbrecht, Harvey J

“…The senescence accelerate mouse P8 (SAMP8) is an excellent model of early learning and memory problems. A number of studies have shown that it has cholinergic…”
Get more information

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease by Hansen, Henrik H, Fabricius, Katrine, Barkholt, Pernille, Niehoff, Michael L, Morley, John E, Jelsing, Jacob, Pyke, Charles, Knudsen, Lotte Bjerre, Farr, Susan A, Vrang, Niels

“…Recent studies indicate that glucagon-like peptide 1 (GLP-1) receptor agonists, currently used in the management of type 2 diabetes, exhibit neurotrophic and…”
Get more information

Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairment by Squillace, Silvia, Niehoff, Michael L, Doyle, Timothy M, Green, Michael, Esposito, Emanuela, Cuzzocrea, Salvatore, Arnatt, Christopher K, Spiegel, Sarah, Farr, Susan A, Salvemini, Daniela

“…Cancer-related cognitive impairment (CRCI) is a major neurotoxicity affecting more than 50% of cancer survivors. The underpinning mechanisms are mostly…”
Get full text

Alzheimer Disease by Morley, John E., MB,BCh, Farr, Susan A., PhD, Nguyen, Andrew D., PhD

“…Alzheimer disease is due to increased amyloid-β coupled with low progranulin. Several brain imaging techniques are helpful in the diagnosis. Drugs available…”
Get full text

Adenosine A3 receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injury by Farr, Susan A, Cuzzocrea, Salvatore, Esposito, Emanuela, Campolo, Michela, Niehoff, Michael L, Doyle, Timothy M, Salvemini, Daniela

“…Abstract Background Traumatic brain injury (TBI) is a common pathological condition that presently lacks a specific pharmacological treatment. Adenosine levels…”
Get full text

Central Nervous System Delivery of Intranasal Insulin: Mechanisms of Uptake and Effects on Cognition by Salameh, Therese S, Bullock, Kristin M, Hujoel, Isabel A, Niehoff, Michael L, Wolden-Hanson, Tami, Kim, Junghyun, Morley, John E, Farr, Susan A, Banks, William A

“…Intranasal insulin has shown efficacy in patients with Alzheimer's disease (AD), but there are no preclinical studies determining whether or how it reaches the…”
Get more information

Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn R493X mouse model of frontotemporal dementia by Smith, Denise M, Niehoff, Michael L, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank, Farr, Susan A, Wilkinson, Miles F, Nguyen, Andrew D

“…A common cause of frontotemporal dementia (FTD) are nonsense mutations in the progranulin (GRN) gene. Because nonsense mutations activate the nonsense-mediated…”
Get full text

Obesity and Hypertriglyceridemia Produce Cognitive Impairment by Farr, Susan A, Yamada, Kelvin A, Butterfield, D. Allan, Abdul, H. Mohammad, Xu, Lin, Miller, Nicole E, Banks, William A, Morley, John E

“…Obesity is associated with cognitive impairments. Long-term mechanisms for this association include consequences of hyperglycemia, dyslipidemia, or other…”
Get full text

Effect of botanical extracts containing carnosic acid or rosmarinic acid on learning and memory in SAMP8 mice by Farr, Susan A, Niehoff, Michael L, Ceddia, Michael A, Herrlinger, Kelli A, Lewis, Brandon J, Feng, Shulin, Welleford, Andrew, Butterfield, D. Allan, Morley, John E

“…Abstract Oxidative damage is one of the hallmarks of the aging process. The current study evaluated effects of two proprietary antioxidant-based ingredients,…”
Get full text

Association Between Metformin Initiation and Incident Dementia Among African American and White Veterans Health Administration Patients by Scherrer, Jeffrey F., PhD, Morley, John E., MBBCh, Salas, Joanne, MPH, Floyd, James S., MD, Farr, Susan A., PhD, Dublin, Sascha, MD

“…AbstractPurposeAfrican American patients are more likely to experience cognitive decline after type 2 diabetes mellitus onset than white patients. Metformin…”
Get full text

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease by Roby, Deborah A, Ruiz, Fernanda, Kermath, Bailey A, Voorhees, Jaymie R, Niehoff, Michael, Zhang, Jinsong, Morley, John E, Musiek, Erik S, Farr, Susan A, Burris, Thomas P

“…Alzheimer's disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the…”
Get full text

Intranasal delivery of N-terminal modified leptin-pluronic conjugate for treatment of obesity by Yuan, Dongfen, Yi, Xiang, Zhao, Yuling, Poon, Chi-Duen, Bullock, Kristin M., Hansen, Kim M., Salameh, Therese S., Farr, Susan A., Banks, William A., Kabanov, Alexander V.

“…Leptin is an adipocyte-secreted hormone that is delivered via a specific transport system across the blood-brain barrier (BBB) to the brain where it acts on…”
Get full text

Ghrelin controls hippocampal spine synapse density and memory performance by Horvath, Tamas L, Diano, Sabrina, Farr, Susan A, Benoit, Stephen C, McNay, Ewan C, da Silva, Ivaldo, Horvath, Balazs, Gaskin, F Spencer, Nonaka, Naoko, Jaeger, Laura B, Banks, William A, Morley, John E, Pinto, Shirly, Sherwin, Robert S, Xu, Lin, Yamada, Kelvin A, Sleeman, Mark W, Tschöp, Matthias H

“…The gut hormone and neuropeptide ghrelin affects energy balance and growth hormone release through hypothalamic action that involves synaptic plasticity in the…”
Get full text

Extra virgin olive oil improves learning and memory in SAMP8 mice by Farr, Susan A, Price, Tulin O, Dominguez, Ligia J, Motisi, Antonio, Saiano, Filippo, Niehoff, Michael L, Morley, John E, Banks, William A, Ercal, Nuran, Barbagallo, Mario

“…Polyphenols are potent antioxidants found in extra virgin olive oil (EVOO); antioxidants have been shown to reverse age- and disease-related learning and…”
Get more information

Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice by Singh, Anand Kumar, Mahalingam, Rajasekaran, Squillace, Silvia, Jacobson, Kenneth A, Tosh, Dilip K, Dharmaraj, Shruti, Farr, Susan A, Kavelaars, Annemieke, Salvemini, Daniela, Heijnen, Cobi J

“…Abstract Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often develop cognitive impairments, sensorimotor deficits, and…”
Get full text

Neurovascular protection by adropin in experimental ischemic stroke through an endothelial nitric oxide synthase-dependent mechanism by Yang, Changjun, Lavayen, Bianca P., Liu, Lei, Sanz, Brian D., DeMars, Kelly M., Larochelle, Jonathan, Pompilus, Marjory, Febo, Marcelo, Sun, Yu-Yo, Kuo, Yi-Min, Mohamadzadeh, Mansour, Farr, Susan A., Kuan, Chia-Yi, Butler, Andrew A., Candelario-Jalil, Eduardo

“…Adropin is a highly-conserved peptide that has been shown to preserve endothelial barrier function. Blood-brain barrier (BBB) disruption is a key pathological…”
Get full text

Delivery of galanin-like peptide to the brain: targeting with intranasal delivery and cyclodextrins by Nonaka, Naoko, Farr, Susan A, Kageyama, Haruaki, Shioda, Seiji, Banks, William A

“…Galanin-like peptide (GALP) shows potential as a therapeutic in the treatment of obesity and related conditions. In this study, we compared the uptake by brain…”
Get more information

Alzheimer Mythology: A Time to Think Out of the Box by Morley, John E., MB, BCh, Farr, Susan A., PhD

Get full text

Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ42 oligomers via a metalloproteinase-dependent mechanism by Sandoval, Karin E, Farr, Susan A, Banks, William A, Crider, Albert M, Morley, John E, Witt, Ken A

“…Abstract Soluble amyloid-β peptide (Aβ) oligomers have been hypothesized to be primary mediators of Alzheimer's disease progression. In this regard, reduction…”
Get full text