Search Results - "Farny, Daniel"

Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons by Riemenschneider, Henrick, Guo, Qiang, Bader, Jakob, Frottin, Frédéric, Farny, Daniel, Kleinberger, Gernot, Haass, Christian, Mann, Matthias, Hartl, F. Ulrich, Baumeister, Wolfgang, Hipp, Mark S, Meissner, Felix, Fernández‐Busnadiego, Rubén, Edbauer, Dieter

“…Aggregation of the multifunctional RNA‐binding protein TDP‐43 defines large subgroups of amyotrophic lateral sclerosis and frontotemporal dementia and…”
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Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model by Zhou, Qihui, Mareljic, Nikola, Michaelsen, Meike, Parhizkar, Samira, Heindl, Steffanie, Nuscher, Brigitte, Farny, Daniel, Czuppa, Mareike, Schludi, Carina, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Feederle, Regina, Roth, Stefan, Haass, Christian, Arzberger, Thomas, Liesz, Arthur, Edbauer, Dieter

“…The C9orf72 repeat expansion is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Non‐canonical…”
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Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity by Hartmann, Hannelore, Hornburg, Daniel, Czuppa, Mareike, Bader, Jakob, Michaelsen, Meike, Farny, Daniel, Arzberger, Thomas, Mann, Matthias, Meissner, Felix, Edbauer, Dieter

“…Frontotemporal dementia and amyotrophic lateral sclerosis patients with mutation show cytoplasmic poly-GR and poly-PR aggregates. Short poly-(Gly-Arg) and…”
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Antibodies inhibit transmission and aggregation of C9orf72 poly‐GA dipeptide repeat proteins by Zhou, Qihui, Lehmer, Carina, Michaelsen, Meike, Mori, Kohji, Alterauge, Dominik, Baumjohann, Dirk, Schludi, Martin H, Greiling, Johanna, Farny, Daniel, Flatley, Andrew, Feederle, Regina, May, Stephanie, Schreiber, Franziska, Arzberger, Thomas, Kuhm, Christoph, Klopstock, Thomas, Hermann, Andreas, Haass, Christian, Edbauer, Dieter

“…Cell‐to‐cell transmission of protein aggregates is an emerging theme in neurodegenerative disease. Here, we analyze the dipeptide repeat (DPR) proteins that…”
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Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo by Riemenschneider, Henrick, Simonetti, Francesca, Sheth, Udit, Katona, Eszter, Roth, Stefan, Hutten, Saskia, Farny, Daniel, Michaelsen, Meike, Nuscher, Brigitte, Schmidt, Michael K, Flatley, Andrew, Schepers, Aloys, Gruijs da Silva, Lara A, Zhou, Qihui, Klopstock, Thomas, Liesz, Arthur, Arzberger, Thomas, Herms, Jochen, Feederle, Regina, Gendron, Tania F, Dormann, Dorothee, Edbauer, Dieter

“…Cytoplasmic aggregation and concomitant nuclear clearance of the RNA-binding protein TDP-43 are found in ~ 90% of cases of amyotrophic lateral sclerosis and ~…”
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Cell‐to‐cell transmission of C9orf72 poly‐(Gly‐Ala) triggers key features of ALS/FTD by Khosravi, Bahram, LaClair, Kathrine D, Riemenschneider, Henrick, Zhou, Qihui, Frottin, Frédéric, Mareljic, Nikola, Czuppa, Mareike, Farny, Daniel, Hartmann, Hannelore, Michaelsen, Meike, Arzberger, Thomas, Hartl, F Ulrich, Hipp, Mark S, Edbauer, Dieter

“…The C9orf72 repeat expansion causes amyotrophic lateral sclerosis and frontotemporal dementia, but the poor correlation between C9orf72 ‐specific pathology and…”
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Author Correction: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons by Riemenschneider, Henrick, Guo, Qiang, Bader, Jakob, Frottin, Frédéric, Farny, Daniel, Kleinberger, Gernot, Haass, Christian, Mann, Matthias, Hartl, F Ulrich, Baumeister, Wolfgang, Hipp, Mark S, Meissner, Felix, Fernández-Busnadiego, Rubén, Edbauer, Dieter

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Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS by LaClair, Katherine D., Zhou, Qihui, Michaelsen, Meike, Wefers, Benedikt, Brill, Monika S., Janjic, Aleksandar, Rathkolb, Birgit, Farny, Daniel, Cygan, Mikolaj, de Angelis, Martin Hrabe, Wurst, Wolfgang, Neumann, Manuela, Enard, Wolfgang, Misgeld, Thomas, Arzberger, Thomas, Edbauer, Dieter

“…Expansion of a (G 4 C 2 ) n repeat in C9orf72 causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the link of the five…”
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Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G 4 C 2 ) n expression in C9orf72 ALS/FTD by Czuppa, Mareike, Dhingra, Ashutosh, Zhou, Qihui, Schludi, Carina, König, Laura, Scharf, Elisabeth, Farny, Daniel, Dalmia, Anupriya, Täger, Joachim, Castillo-Lizardo, Melissa, Katona, Eszter, Mori, Kohji, Aumer, Tina, Schelter, Florian, Müller, Markus, Carell, Thomas, Kalliokoski, Tuomo, Messinger, Josef, Rizzu, Patrizia, Heutink, Peter, Edbauer, Dieter

“…An intronic (G C ) expansion in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal dementia primarily through gain-of-function mechanisms: the…”
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