Search Results - "Farnham, P."

ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells by Krig, S R, Miller, J K, Frietze, S, Beckett, L A, Neve, R M, Farnham, P J, Yaswen, P I, Sweeney, C A

“…Understanding the mechanisms underlying ErbB3 overexpression in breast cancer will facilitate the rational design of therapies to disrupt ErbB2-ErbB3 oncogenic…”
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Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters by Weinmann, Amy S., Bartley, Stephanie M., Zhang, Theresa, Zhang, Michael Q., Farnham, Peggy J.

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T-bet Regulates the Terminal Maturation and Homeostasis of NK and V alpha 14i NKT Cells by Townsend, MJ, Weinmann, A S, Matsuda, J L, Salomon, R, Farnham, P J, Biron, CA, Gapin, L, Glimcher, L H

“…Natural killer (NK) and CD1d-restricted V alpha 14i natural killer T (NKT) cells play a critical early role in host defense. Here we show that mice with a…”
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Target Gene Specificity of E2F and Pocket Protein Family Members in Living Cells by Wells, Julie, Boyd, Kathryn E., Fry, Christopher J., Bartley, Stephanie M., Farnham, Peggy J.

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Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27 by Kirmizis, Antonis, Bartley, Stephanie M, Kuzmichev, Andrei, Margueron, Raphael, Reinberg, Danny, Green, Roland, Farnham, Peggy J

“…Polycomb group (PcG) complexes 2 and 3 are involved in transcriptional silencing. These complexes contain a histone lysine methyltransferase (HKMT) activity…”
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Introduction to the E2F family: protein structure and gene regulation by Slansky, J E, Farnham, P J

“…E2F is a heterodimer composed of two partners, such as E2F1 and DP1. Although E2F1 can bind DNA as a homodimer and increase promoter activity, optimal…”
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Mre11 Complex and DNA Replication: Linkage to E2F and Sites of DNA Synthesis by Maser, Richard S., Mirzoeva, Olga K., Wells, Julie, Olivares, Heidi, Williams, Bret R., Zinkel, Robert A., Farnham, Peggy J., Petrini, John H. J.

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Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis by Weinmann, Amy S, Yan, Pearlly S, Oberley, Matthew J, Huang, Tim Hui-Ming, Farnham, Peggy J

“…Previously, identification of promoters regulated by mammalian transcription factors has relied upon overexpression studies. Here we present the identification…”
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Myc Recruits P-TEFb to Mediate the Final Step in the Transcriptional Activation of the cad Promoter by Eberhardy, Scott R, Farnham, Peggy J

“…The c-Myc protein is up-regulated in many different types of cancer, suggesting that a detailed understanding of Myc function is an important goal. Our…”
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c-Myc Mediates Activation of the cad Promoter via a Post-RNA Polymerase II Recruitment Mechanism by Eberhardy, Scott R., Farnham, Peggy J.

“…The c-Myc protein is a site-specific DNA-binding transcription factor that is up-regulated in a number of different cancers. We have previously shown that…”
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Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties by Kaelin, Jr, W G, Krek, W, Sellers, W R, DeCaprio, J A, Ajchenbaum, F, Fuchs, C S, Chittenden, T, Li, Y, Farnham, P J, Blanar, M A

“…An expression vector was modified to permit the rapid synthesis of purified, 32P-labeled, glutathione S-transferase (GST)-retinoblastoma (RB) fusion proteins…”
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Myc versus USF: discrimination at the cad gene is determined by core promoter elements by Boyd, Kathryn E., Farnham, Peggy J.

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A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter by SLANSKY, J. E, YUE LI, KAELIN, W. G, FARNHAM, P. J

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Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter by Hsiao, K M, McMahon, S L, Farnham, P J

“…To prepare for the DNA synthesis (S) phase of the cell cycle, transcription of many genes required for nucleotide biosynthesis increases. The promoters of…”
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Analysis of Myc Bound Loci Identified by CpG Island Arrays Shows that Max Is Essential for Myc-Dependent Repression by Mao, Daniel Y.L., Watson, John D., Yan, Pearlly S., Barsyte-Lovejoy, Dalia, Khosravi, Fereshteh, Wong, W.Wei-Lynn, Farnham, Peggy J., Huang, Tim H.-M., Penn, Linda Z.

“…The c-myc proto-oncogene encodes a transcription factor, c-Myc, which is deregulated and/or overexpressed in many human cancers. Despite c-Myc's importance,…”
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Coexamination of Site-Specific Transcription Factor Binding and Promoter Activity in Living Cells by Boyd, Kathryn E., Farnham, Peggy J.

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Identification of novel pRb binding sites using CpG microarrays suggests that E2F recruits pRb to specific genomic sites during S phase by WELLS, Julie, YAN, Pearlly S, CECHVALA, Meredith, TIM HUANG, FARNHAM, Peggy J

“…The retinoblastoma (Rb) tumor suppressor protein is an important regulator of cell proliferation and differentiation. Many studies have shown that pRb can…”
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Exogenous E2F expression is growth inhibitory before, during, and after cellular transformation by LEE, T. A, FARNHAM, P. J

“…To gain insight into the tumor suppressor properties of E2F1, we investigated growth inhibition by the E2F family of transcription factors using a tissue…”
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c-Myc Target Gene Specificity is Determined by a Post-DNA-Binding Mechanism by Boyd, Kathryn E., Wells, Julie, Gutman, Julie, Bartley, Stephanie M., Farnham, Peggy J.

“…Uncertainty as to which member of a family of DNA-binding transcription factors regulates a specific promoter in intact cells is a problem common to many…”
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Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors by Kel, Alexander E., Kel-Margoulis, Olga V., Farnham, Peggy J., Bartley, Stephanie M., Wingender, Edgar, Zhang, Michael Q.

“…The processes that take place during development and differentiation are directed through coordinated regulation of expression of a large number of genes. One…”
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