Search Results - "Farnham, Melissa M J"

Slow but Steady—The Responsiveness of Sympathoadrenal System to a Hypoglycemic Challenge in Ketogenic Diet-Fed Rats by Nedoboy, Polina E, Cohen, Myfanwy, Farnham, Melissa M.-J

“…The sympathoadrenal counterregulatory response to hypoglycemia is critical for individuals with type 1 diabetes due to impaired ability to produce glucagon…”
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Still Excited, but Less Aroused-The Effects of Nutritional Ketosis on Epinephrine Response and Hypothalamic Orexin Neuron Activation Following Recurrent Hypoglycemia in Diabetic Rats by Nedoboy, Polina E, Farnham, Melissa M-J

“…Hypoglycemia-associated autonomic failure (HAAF) is a serious, life-threatening complication of intensive insulin therapy, particularly in people with type 1…”
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PACAP is expressed in sympathoexcitatory bulbospinal C1 neurons of the brain stem and increases sympathetic nerve activity in vivo by Farnham, Melissa M J, Li, Qun, Goodchild, Ann K, Pilowsky, Paul M

“…Pituitary adenylate cyclase-activating polypeptide (PACAP) is an excitatory neuropeptide present in the rat brain stem. The extent of its localization within…”
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Effects of baroreceptor activation on respiratory variability in rat by McMullan, Simon, Dick, Thomas E, Farnham, Melissa M.J, Pilowsky, Paul M

“…Abstract Controversy surrounds the respiratory responses to baroreceptor activation. Although many reflexes that effect respiration (e.g. chemoreflexes and…”
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PACAP-(6-38) or kynurenate microinjections in the RVLM prevent the development of sympathetic long-term facilitation after acute intermittent hypoxia by Kakall, Zohra M, Pilowsky, Paul M, Farnham, Melissa M J

“…Intermittent hypoxia causes a persistent increase in sympathetic activity that progresses to hypertension in chronic conditions such as obstructive sleep…”
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Pentobarbital Anesthesia Suppresses the Glucose Response to Acute Intermittent Hypoxia in Rat by Nedoboy, Polina E, Houlahan, Callum B, Farnham, Melissa M J

“…A key feature of sleep disordered breathing syndromes, such as obstructive sleep apnea is intermittent hypoxia. Intermittent hypoxia is well accepted to drive…”
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Antagonism of PACAP or microglia function worsens the cardiovascular consequences of kainic-acid-induced seizures in rats by Bhandare, Amol M, Mohammed, Suja, Pilowsky, Paul M, Farnham, Melissa M J

“…Seizures are accompanied by cardiovascular changes that are a major cause of sudden unexpected death in epilepsy (SUDEP). Seizures activate inflammatory…”
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Dynamic changes in the relationship of microglia to cardiovascular neurons in response to increases and decreases in blood pressure by Kapoor, Komal, Bhandare, Amol M, Nedoboy, Polina E, Mohammed, Suja, Farnham, Melissa M.J, Pilowsky, Paul M

“…Highlights • Microglia alter spatial distribution in response to changes in blood pressure. • Increased blood pressure causes microglia to contact more…”
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Seizure-Induced Sympathoexcitation Is Caused by Activation of Glutamatergic Receptors in RVLM That Also Causes Proarrhythmogenic Changes Mediated by PACAP and Microglia in Rats by Bhandare, Amol M, Kapoor, Komal, Pilowsky, Paul M, Farnham, Melissa M J

“…Cardiovascular autonomic dysfunction in seizure is a major cause of sudden unexpected death in epilepsy. The catecholaminergic neurons in the rostral…”
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Optogenetics, the intersection between physics and neuroscience: light stimulation of neurons in physiological conditions by Deng, Wei, Goldys, Ewa M, Farnham, Melissa M J, Pilowsky, Paul M

“…Neuronal stimulation by light is a novel approach in the emerging field of optogenetics, where genetic engineering is used to introduce light-activated…”
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PACAP-PAC1 Receptor Activation Is Necessary for the Sympathetic Response to Acute Intermittent Hypoxia by Farnham, Melissa M J, Tallapragada, Vikram J, O'Connor, Edward T, Nedoboy, Polina E, Dempsey, Bowen, Mohammed, Suja, Fong, Angelina Y, Lung, Mandy S Y, Derakhshan, Fatemeh, Wilson, Richard J A, Pilowsky, Paul M

“…Repetitive hypoxia is a key feature of obstructive sleep apnoea (OSA), a condition characterized by intermittent airways obstruction. Patients with OSA present…”
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Intrathecal PACAP-38 causes prolonged widespread sympathoexcitation via a spinally mediated mechanism and increases in basal metabolic rate in anesthetized rat by Inglott, Melissa A, Farnham, Melissa M J, Pilowsky, Paul M

“…The rostral ventrolateral medulla differentially regulates sympathetic output to different vascular beds, possibly through the release of various…”
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Gene Interference with Morpholinos in a Gold Nanoparticle-Based Delivery Platform in Rat PC12 Cells by Deng, Wei, Farnham, Melissa M J, Goldys, Ewa M, Mohammed, Suja, Pilowsky, Paul M

“…For the first time the efficiency of gene knockdown of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor 1 (PAC1R) is demonstrated by…”
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Catestatin has an unexpected effect on the intrathecal actions of PACAP dramatically reducing blood pressure by Gaede, Andrea H, Inglott, Melissa A, Farnham, Melissa M J, Pilowsky, Paul M

“…This study focuses on presympathetic neurons of the rostral ventrolateral medulla (RVLM) that regulate sympathetic vasomotor tone. Many neurotransmitters are…”
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Intermittent hypoxia enhances the expression of hypoxia inducible factor HIF1A through histone demethylation by Martinez, Chloe-Anne, Jiramongkol, Yannasittha, Bal, Neha, Alwis, Imala, Nedoboy, Polina E., Farnham, Melissa M.J., White, Mark D., Cistulli, Peter A., Cook, Kristina M.

“…The cellular response to hypoxia is regulated through enzymatic oxygen sensors, including the prolyl hydroxylases, which control degradation of the well-known…”
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Acute intermittent hypoxia with concurrent hypercapnia evokes P2X and TRPV1 receptor‐dependent sensory long‐term facilitation in naïve carotid bodies by Roy, Arijit, Farnham, Melissa M. J., Derakhshan, Fatemeh, Pilowsky, Paul M., Wilson, Richard J. A.

“…Key points Activity‐dependent plasticity can be induced in carotid body (CB) chemosensory afferents without chronic intermittent hypoxia (CIH) preconditioning…”
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Local anaesthetics for acute reversible blockade of the sympathetic baroreceptor reflex in the rat by Farnham, Melissa M.J., Pilowsky, Paul M.

“…Sinoaortic denervation is a common method used in the investigation of function in the cardiovascular system. In the rat, this is usually accomplished by…”
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Inhibition of microglial activation with minocycline at the intrathecal level attenuates sympathoexcitatory and proarrhythmogenic changes in rats with chronic temporal lobe epilepsy by Bhandare, Amol M., Kapoor, Komal, Powell, Kim L., Braine, Emma, Casillas-Espinosa, Pablo, O'Brien, Terence J., Farnham, Melissa M.J., Pilowsky, Paul M.

“…•Epilepsy-induced altered cardiovascular function, regulated by autonomic nervous system, is a major cause of death.•Chronic spontaneous seizures in rats…”
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Alerted microglia and the sympathetic nervous system: A novel form of microglia in the development of hypertension by Kapoor, Komal, Bhandare, Amol M, Farnham, Melissa M.J, Pilowsky, Paul M

“…Highlights • Microglia are ubiquitously expressed in sympathetic nervous system. • Microglia are capable of modulating sympathetic nerve activity. • Microglial…”
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Integration of hindbrain and carotid body mechanisms that control the autonomic response to cardiorespiratory and glucoprivic insults by Kakall, Zohra M., Cohen, E. Myfanwy, Farnham, Melissa M.J., Kim, Seung Jae, Nedoboy, Polina E., Pilowsky, Paul M.

“…•Autonomic reflex responses are critical to ensure survival.•Hypoxia triggers the carotid body mediated sympathoexcitatory peripheral chemoreflex…”
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