Search Results - "Farmer, P. B."

Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration by GARCEA, G, JONES, D. J. L, SINGH, R, DENNISON, A. R, FARMER, P. B, SHARMA, R. A, STEWARD, W. P, GESCHER, A. J, BERRY, D. P

“…Studies in vitro and in animal models of colorectal and hepatocellular cancers suggest that curcumin is an effective chemopreventive agent. In this pilot…”
Get full text

First‐trimester increase in oxidative stress and risk of small‐for‐gestational‐age fetus by Potdar, N, Singh, R, Mistry, V, Evans, MD, Farmer, PB, Konje, JC, Cooke, MS

“…Objective  Investigation of increased oxidative stress in early pregnancy and association with an increased risk of small‐for‐gestational‐age (SGA) fetus…”
Get full text

Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4'-tetramethoxystilbene by SALE, S, VERSCHOYLE, R. D, BOOCOCK, D, JONES, D. J. L, WILSHER, N, RUPARELIA, K. C, POTTER, G. A, FARMER, P. B, STEWARD, W. P, GESCHER, A. J

“…Resveratrol (trans-3,5,4'-trihydroxystilbene) is a naturally occurring polyphenol with cancer chemopreventive properties in preclinical models of…”
Get full text

Human exposure and internal dose assessments of acrylamide in food by Dybing, E., Farmer, P.B., Andersen, M., Fennell, T.R., Lalljie, S.P.D., Müller, D.J.G., Olin, S., Petersen, B.J., Schlatter, J., Scholz, G., Scimeca, J.A., Slimani, N., Törnqvist, M., Tuijtelaars, S., Verger, P.

“…This review provides a framework contributing to the risk assessment of acrylamide in food. It is based on the outcome of the ILSI Europe FOSIE process, a risk…”
Get full text

Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy by Yang, J, Parsons, J, Nicolay, N H, Caporali, S, Harrington, C F, Singh, R, Finch, D, D’Atri, S, Farmer, P B, Johnston, P G, McKenna, W G, Dianov, G, Sharma, R A

“…A significant proportion of human cancers overexpress DNA polymerase beta (Pol β), the major DNA polymerase involved in base excision repair. The underlying…”
Get full text

Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo by LEONG, C-O, GASKELL, M, MARTIN, E. A, HEYDON, R. T, FARMER, P. B, BIBBY, M. C, COOPER, P. A, DOUBLE, J. A, BRADSHAW, T. D, STEVENS, M. F. G

“…2-(4-Aminophenyl)benzothiazoles represent a potent and highly selective class of antitumour agent. In vitro, sensitive carcinoma cells deplete…”
Get full text

Cyclooxygenase-2 expression and oxidative DNA adducts in murine intestinal adenomas: Modification by dietary curcumin and implications for clinical trials by Tunstall, R.G., Sharma, R.A., Perkins, S., Sale, S., Singh, R., Farmer, P.B., Steward, W.P., Gescher, A.J.

“…The natural polphenol, curcumin, retards the growth of intestinal adenomas in the Apc Min+ mouse model of human familial adenomatous polyposis. In other…”
Get full text

Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity by JONES, D. J. L, LAMB, J. H, VERSCHOYLE, R. D, HOWELLS, L. M, BUTTERWORTH, M, LIM, C. K, FERRY, D, FARMER, P. B, GESCHER, A. J

“…Quercetin (3,5,7,3',4'-pentahydroxyflavone) is a flavone with putative ability to prevent cancer and cardiovascular diseases. Its metabolism was evaluated in…”
Get full text

The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1 by Potter, G A, Patterson, L H, Wanogho, E, Perry, P J, Butler, P C, Ijaz, T, Ruparelia, K C, Lamb, J H, Farmer, P B, Stanley, L A, Burke, M D

Get full text

Methods of DNA adduct determination and their application to testing compounds for genotoxicity by Phillips, D. H., Farmer, P. B., Beland, F. A., Nath, R. G., Poirier, M. C., Reddy, M. V., Turteltaub, K. W.

“…At the International Workshop on Genotoxicity Test Procedures (IWGTP) held in Washington, DC (March 25–26, 1999), a working group considered the uses of DNA…”
Get full text

Genotoxic damage in mine workers exposed to diesel exhaust, and the effects of glutathione transferase genotypes by Knudsen, L.E., Gaskell, M., Martin, E.A., Poole, J., Scheepers, P.T.J., Jensen, A., Autrup, H., Farmer, P.B

“…This study was performed in an Estonian shale-oil mine with the purpose to develop and apply a number of biomarkers for occupational diesel-exhaust exposure…”
Get full text

Styrene-oxide N-terminal valine haemoglobin adducts in reinforced plastic workers: Possible influence of genetic polymorphism of drug-metabolising enzymes by Teixeira, J.P, Gaspar, J, Roma-Torres, J, Silva, S, Costa, C, Roach, J, Mayan, O, Rueff, J, Farmer, P.B

“…Abstract Styrene is one of the most important organic chemicals used worldwide. In humans, styrene metabolism involves oxidation by cytochrome P450…”
Get full text

Mutagenicity, carcinogenicity, and teratogenicity of acrylonitrile by Léonard, A, Gerber, G.B, Stecca, C, Rueff, J, Borba, H, Farmer, P.B, Sram, R.J, Czeizel, A.E, Kalina, I

“…Acrylonitrile (AN) is an important intermediary for the synthesis of a variety of organic products, such as artificial fibres, household articles and resins…”
Get full text

Styrene-oxide N-terminal valine haemoglobin adducts as biomarkers of occupational exposure to styrene by Teixeira, J.P., Silva, S., Torres, J., Gaspar, J., Roach, J., Farmer, P.B., Rueff, J., Mayan, O.

“…Styrene is widely used in the production of various plastics, synthetic rubber and resins. Occupational exposure occurs mainly via inhalation and relatively…”
Get full text

Determination of malondialdehyde-induced DNA damage in human tissues using an immunoslot blot assay by LEURATTI, C, SINGH, R, LAGNEAU, C, FARMER, P. B, PLASTARAS, J. P, MARNETT, L. J, SHUKER, D. E. G

“…Malondialdehyde (MDA) is a product of lipid peroxidation and prostaglandin biosynthesis. It is mutagenic and carcinogenic and the major adduct formed by…”
Get full text

In vitro genotoxicity of PAH mixtures and organic extract from urban air particles part II: human cell lines by Sevastyanova, O, Binkova, B, Topinka, J, Sram, R J, Kalina, I, Popov, T, Novakova, Z, Farmer, P B

“…Principal aims of this study were at first, to find a relevant human derived cell line to investigate the genotoxic potential of PAH-containing complex…”
Get more information

Benzene and non-Hodgkin's lymphoma by O'Connor, Simon R., Farmer, Peter B., Lauder, Ian

“…Incidence rates for non‐Hodgkin's lymphoma (NHL) have been rising throughout the world for several decades, and no convincing explanation exists for the…”
Get full text

Metabolic fate of [3H]-l-menthol in the rat by Yamaguchi, T, Caldwell, J, Farmer, P B

“…[3-3H]-l-Menthol was administered by oral gavage to intact and bile duct-cannulated male Fischer 344 rats at a dose level of 500 mg/kg. Excreta were collected…”
Get more information

DNA adducts: Mass spectrometry methods and future prospects by Farmer, P.B., Brown, K., Tompkins, E., Emms, V.L., Jones, D.J.L., Singh, R., Phillips, D.H.

“…Detection of DNA adducts is widely used for the monitoring of exposure to genotoxic carcinogens. Knowledge of the nature and amounts of DNA adducts formed in…”
Get full text

Biomonitoring of diesel exhaust-exposed workers. DNA and hemoglobin adducts and urinary 1-hydroxypyrene as markers of exposure by Nielsen, Per Sabro, Andreassen, Åshild, Farmer, Peter B., Ørebø, Steinar, Autrup, Herman

“…Diesel exhaust-exposed workers have been shown to have an increased risk of lung cancer. A battery of biomarkers were evaluated for their ability to assess…”
Get full text