Search Results - "Farman, Nicolette"
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Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis
Published in Progress in retinal and eye research (01-09-2015)“…Central serous chorioretinopathy (CSCR) is a major cause of vision threat among middle-aged male individuals. Multimodal imaging led to the description of a…”
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Cutaneous Wound Healing in Diabetic Mice Is Improved by Topical Mineralocorticoid Receptor Blockade
Published in Journal of investigative dermatology (01-01-2020)“…Skin ulcers resulting from impaired wound healing are a serious complication of diabetes. Unresolved inflammation, associated with the dysregulation of both…”
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3
Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy
Published in The Journal of clinical investigation (01-07-2012)“…Central serous chorioretinopathy (CSCR) is a vision-threatening eye disease with no validated treatment and unknown pathogeny. In CSCR, dilation and leakage of…”
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Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration
Published in Nature communications (21-01-2019)“…Choroidal neovascularization (CNV) is a major cause of visual impairment in patients suffering from wet age-related macular degeneration (AMD), particularly…”
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Nanostructured Dense Collagen‐Polyester Composite Hydrogels as Amphiphilic Platforms for Drug Delivery
Published in Advanced science (01-04-2021)“…Associating collagen with biodegradable hydrophobic polyesters constitutes a promising method for the design of medicated biomaterials. Current…”
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6
endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure
Published in The FASEB journal (01-07-2010)“…Pathophysiological aldosterone (aldo)/mineralocorticoid receptor (MR) signaling has significant effects on the cardiovascular system, resulting in hypertension…”
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neuroretina is a novel mineralocorticoid target: aldosterone up-regulates ion and water channels in Müller glial cells
Published in The FASEB journal (01-09-2010)“…Glucocorticoids reduce diabetic macular edema, but the mechanisms underlying glucocorticoid effects are imperfectly elucidated. Glucocorticoids may bind to…”
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Aldosterone-Specific Activation of Cardiomyocyte Mineralocorticoid Receptor In Vivo
Published in Hypertension (Dallas, Tex. 1979) (01-02-2013)“…Inappropriate mineralocorticoid receptor (MR) activation is involved in cardiac diseases. Whether and how aldosterone is involved in the deleterious effects of…”
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Differential regulations of AQP4 and Kir4.1 by triamcinolone acetonide and dexamethasone in the healthy and inflamed retina
Published in Investigative ophthalmology & visual science (11-08-2011)“…Glucocorticoids are used to treat macular edema, although the mechanisms underlying this effect remain largely unknown. The authors have evaluated in the…”
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Regulation of WNK1 Expression by miR-192 and Aldosterone
Published in Journal of the American Society of Nephrology (01-10-2010)“…WNK1 and WNK4 encode two members of the WNK serine-threonine kinase subfamily. Greater WNK1 expression associates with higher BP. A combination of promoters,…”
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Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias
Published in Circulation (New York, N.Y.) (14-06-2005)“…Life-threatening cardiac arrhythmia is a major source of mortality worldwide. Besides rare inherited monogenic diseases such as long-QT or Brugada syndromes,…”
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Multiple aspects of mineralocorticoid selectivity
Published in American journal of physiology. Renal physiology (01-02-2001)“…Aldosterone regulates renal sodium reabsorption through binding to the mineralocorticoid receptor (MR). Because the glucocorticoid receptor (GR) is expressed…”
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Molecular Signature of Mineralocorticoid Receptor Signaling in Cardiomyocytes: From Cultured Cells to Mouse Heart
Published in Endocrinology (Philadelphia) (01-09-2010)“…Excess mineralocorticoid signaling is deleterious for cardiovascular functions, as demonstrated by the beneficial effects of mineralocorticoid receptor (MR)…”
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The aldosterone-mineralocorticoid receptor pathway exerts anti-inflammatory effects in endotoxin-induced uveitis
Published in PloS one (09-11-2012)“…We have previously shown that the eye is a mineralocorticoid-sensitive organ and we now question the role of mineralocorticoid receptor (MR) in ocular…”
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The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling
Published in PloS one (23-01-2012)“…Experimental and clinical studies have shown that aldosterone/mineralocorticoid receptor (MR) activation has deleterious effects in the cardiovascular system;…”
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Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia
Published in The American journal of pathology (01-09-2007)“…The mineralocorticoid receptor (MR) is a transcription factor of the nuclear receptor family, activation of which by aldosterone enhances salt reabsorption in…”
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The Mineralocorticoid Receptor Is a Constitutive Nuclear Factor in Cardiomyocytes due to Hyperactive Nuclear Localization Signals
Published in Endocrinology (Philadelphia) (01-08-2010)“…The mineralocorticoid receptor (MR), a member of the nuclear receptor family, mediates the action of aldosterone in target epithelia, enhancing sodium…”
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The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon?
Published in Experimental dermatology (01-02-2010)“…Please cite this paper as: The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon? Experimental Dermatology 2010; 19:…”
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Cloning and Expression of a Novel pH-sensitive Two Pore Domain K+ Channel from Human Kidney
Published in The Journal of biological chemistry (20-11-1998)“…A complementary DNA encoding a novel K+ channel, called TASK-2, was isolated from human kidney and its gene was mapped to chromosome 6p21. TASK-2 has a low…”
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Aldosterone promotes cardiac endothelial cell proliferation in vivo
Published in Journal of the American Heart Association (06-01-2015)“…Experimentally, aldosterone in association with NaCl induces cardiac fibrosis, oxidative stress, and inflammation through mineralocorticoid receptor…”
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