Search Results - "Farman, Cindy"

Proceedings of the 2015 National Toxicology Program Satellite Symposium by Elmore, Susan A., Farman, Cindy A., Hailey, James R., Kovi, Ramesh C., Malarkey, David E., Morrison, James P., Neel, Jennifer, Pesavento, Patricia A., Porter, Brian F., Szabo, Kathleen A., Teixeira, Leandro B. C., Quist, Erin M.

“…The 2015 Annual National Toxicology Program Satellite Symposium, entitled “Pathology Potpourri” was held in Minneapolis, Minnesota, at the American College of…”
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Oligodeoxynucleotide Studies in Primates: Antisense and Immune Stimulatory Indications by Farman, Cindy A., Kornbrust, Doug J.

“…Antisense oligodeoxynucleotide compounds (AS ODN) are being developed as therapeutics for various disease indications. Their safety and pharmacokinetics are…”
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The safety evaluation of long-acting ocular delivery systems by Thackaberry, Evan A., Lorget, Florence, Farman, Cindy, Bantseev, Vladimir

“…•The anatomy and physiology of the eye provides challenges for the development of LAD technologies.•The complexity of LADs further complicates their safety…”
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Oligodeoxynucleotide studies in primates: Antisense and immune stimulatory indications by FARMAN, Cindy A, KORNBRUST, Doug J

“…Antisense oligodeoxynucleotide compounds (AS ODN) are being developed as therapeutics for various disease indications. Their safety and pharmacokinetics are…”
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Evaluation of the Toxicity of Intravitreally Injected PLGA Microspheres and Rods in Monkeys and Rabbits: Effects of Depot Size on Inflammatory Response by Thackaberry, Evan A, Farman, Cindy, Zhong, Fiona, Lorget, Florence, Staflin, Karin, Cercillieux, Angelique, Miller, Paul E, Schuetz, Chris, Chang, Debby, Famili, Amin, Daugherty, Ann L, Rajagopal, Karthik, Bantseev, Vladimir

“…Poly(lactic-co-glycolic) acid (PLGA) inserts have been successfully developed for the treatment of posterior eye disease as a means of reducing injection…”
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Scientific and Regulatory Policy Committee Points to Consider: Fixation, Trimming, and Sectioning of Nonrodent Eyes and Ocular Tissues for Examination in Ocular and General Toxicity Studies by Booler, Helen S., Lejeune, Typhaine, Sorden, Steven, Gruebbel, Margarita M., Schafer, Kenneth A., Short, Brian, Farman, Cindy, Ramos, Meg Ferrell, Bennet, Bindu, Yekkala, Krishna, Atzpodien, Elke-Astrid, Turner, Oliver C., Brassard, Jaqueline, Foley, George

“…A Working Group of the Society of Toxicologic Pathology’s Scientific and Regulatory Policy Committee conducted a technical and scientific review of current…”
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Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs by Katavolos, Paula, Cain, Gary, Farman, Cindy, Romero, F. Anthony, Magnuson, Steven, Ly, Justin Q., Choo, Edna F., Katakam, Anand Kumar, Andaya, Roxanne, Maher, Jonathan

“…Cyclic adenosine monophosphate-response element (CREB)-binding protein (CBP) and EP300E1A-binding protein (p300) are members of the bromodomain and…”
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Lens Capsule Perforation Without Inflammation in 4 Rabbits From Intravitreal Injection Studies by Farman, Cindy, Schuetz, Chris, Lorget, Florence, Bantseev, Vladimir, Calise, David, Thackaberry, Evan A.

“…Historically, it was thought that lens protein was sequestered, and injury to the lens capsule causing release of lens material into the eye would always…”
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Determination of a No-Observable Effect Level for Endotoxin Following a Single Intravitreal Administration to Dutch Belted Rabbits by Bantseev, Vladimir, Miller, Paul E, Bentley, Ellison, Schuetz, Chris, Streit, Tim M, Christian, Brian J, Farman, Cindy, Booler, Helen, Thackaberry, Evan A

“…The purpose of this study was to characterize the inflammatory response and determine a no-observable effect level (NOEL) in rabbit eyes after endotoxin…”
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Rapid Development of Glaucoma Via ITV Nonselective ANGPT 1/2 Antibody: A Potential Role for ANGPT/TIE2 Signaling in Primate Aqueous Humor Outflow by Thackaberry, Evan A, Zhou, Yi, Zuch de Zafra, Christina L, Fuh, Germaine, Lee, Chingwei V, Sanowar, Sarah, Ridgway, John B, Kusi, Aija M, Farman, Cindy, Booler, Helen, Sheinson, Daniel, Rasmussen, Carol A, Miller, Paul E, Wakshull, Eric, Yan, Minhong, Bantseev, Vladimir

“…Investigate a significant, dose-related increase in IOP, leading to glaucomatous damage to the neuroretina and optic nerve following intravitreal (ITV)…”
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Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics by de Zafra, Christina L.Zuch, Sasseville, Vito G., Matsumoto, Steven, Freichel, Christian, Milton, Mark, MacLachlan, Timothy K., Farman, Cindy, Raymond, Iona, Gupta, Swati, Newton, Ronald, Atzpodien, Elke-Astrid, Thackaberry, Evan A.

“…The nonclinical safety evaluation of therapeutic drug candidates is commonly conducted in two species (rodent and non-rodent) in keeping with international…”
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Centriacinar Remodeling and Sustained Procollagen Gene Expression after Exposure to Ozone and Nitrogen Dioxide by Farman, Cindy A, Watkins, Karen, van Hoozen, Brent, Last, Jerold A, Witschi, Hanspeter, Pinkerton, Kent E

“…Sprague-Dawley rats were exposed to 0.8 ppm ozone (O3), to 14.4 ppm nitrogen dioxide (NO2), or to both gases simultaneously for 6 h per day for up to 90 d. The…”
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Meningoencephalitis Due to a Sarcocystis Neurona-like Protozoan in Pacific Harbor Seals (Phoca vitulina richardsi) by Lapointe, Jean-Martin, Duignan, Padraig J., Marsh, Antoinette E., Gulland, Frances M., Barr, Bradd C., Naydan, Diane K., King, Don P., Farman, Cindy A., Kathy A. Burek Huntingdon, Lowenstine, Linda J.

“…Seven Pacific harbor seals with meningoencephalitis associated with Sarcocystis neurona-like protozoa are described. Six of the 7 seals were free-ranging and…”
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Corrigendum to “Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics” [Regul. Toxicol. Pharmacol. (2017) 221–230] by de Zafra, Christina L.Zuch, Sasseville, Vito G., Matsumoto, Steven, Freichel, Christian, Milton, Mark, MacLachlan, Timothy K., Farman, Cindy, Raymond, Iona, Gupta, Swati, Newton, Ronald, Atzpodien, Elke-Astrid, Thackaberry, Evan A.

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Chronic inhalation of mixtures of ozone and nitrogen dioxide by Sprague-Dawley rats: A model of chronic pulmonary injury, inflammation, fibrosis and repair by Farman, Cindy Ann Carlson

“…Simultaneous exposure of Sprague-Dawley rats to 0.8 ppm ozone (O 3) and 14.4 ppm nitrogen dioxide (NO2) causes centriacinar damage, characterized by epithelial…”
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Pharmacologic and pharmacokinetic profile of repifermin (KGF-2) in monkeys and comparative pharmacokinetics in humans by Sung, Cynthia, Parry, Tom J., Riccobene, Todd A., Mahoney, Angela, Roschke, Viktor, Murray, James, Gu, Mi Li, Glenn, Jeffrey K., Caputo, Florence, Farman, Cindy, Odenheimer, Daniel J.

“…Repifermin (truncated, recombinant human keratinocyte growth factor-2, KGF-2) was evaluated in cynomolgus monkeys and healthy humans during a phase 1 trial…”
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Pharmacologic and pharmacokinetic profile of repifermin (KGF-2) in monkeys and comparative pharmacokinetics in humans by Sung, Cynthia, Parry, Tom J, Riccobene, Todd A, Mahoney, Angela, Roschke, Viktor, Murray, James, Gu, Mi Li, Glenn, Jeffrey K, Caputo, Florence, Farman, Cindy, Odenheimer, Daniel J

“…Repifermin (truncated, recombinant human keratinocyte growth factor-2, KGF-2) was evaluated in cynomolgus monkeys and healthy humans during a phase 1 trial…”
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