THYROID FUNCTION AND GHRELIN AND LEPTIN LEVELS IN OBESE CHILDREN AND ADOLESCENTS WITH AND WITHOUT INSULIN RESISTANCE

THYROID FUNCTION AND GHRELIN AND LEPTIN LEVELS IN OBESE CHILDREN AND ADOLESCENTS WITH AND WITHOUT INSULIN RESISTANCE

INTRODUCTION: Thyroid hormones ghrelin, leptin, and insulin are implicated in energy metabolism. OBJECTIVE: The objective of this study was to investigate any relationship between thyroid function and ghrelin and leptin levels in selected euthyroid (thyrotropin: 0.35–4.94; free thyroxine [fT4]: 0.8–...

Full description

Saved in:
Bibliographic Details
Published in:Pediatrics (Evanston) Vol. 121; no. Supplement_2; p. S150
Main Authors: Stylianou, Charilaos, Galli-Tsinopoulou, Assimina, Kokka, Paraskevi, Farmakiotis, Demetrios, Koliakos, George, Varlamis, George
Format: Journal Article
Language:English
Published: Evanston American Academy of Pediatrics 01-01-2008
Subjects:
Children & youth
Drug resistance
Hormones
Insulin
Obesity
Pediatrics
Studies
Thyroid gland
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:INTRODUCTION: Thyroid hormones ghrelin, leptin, and insulin are implicated in energy metabolism. OBJECTIVE: The objective of this study was to investigate any relationship between thyroid function and ghrelin and leptin levels in selected euthyroid (thyrotropin: 0.35–4.94; free thyroxine [fT4]: 0.8–1.8; no autoimmune thyroiditis or iodine deficiency, no medications intake) obese children and adolescents with and without insulin resistance (IR). METHODS: Forty obese children and 40 obese adolescents were enrolled. BMI, percentage of body fat, fasting glucose, insulin, ghrelin, leptin, thyrotropin, free triiodothyronine (fT3), and fT4 were measured. IR was estimated with homeostasis model assessment of IR index. The Mann-Whitney U test for independent samples was applied. Correlations were assessed by the Spearman coefficient. RESULTS: In adolescents, fT3 levels were positively correlated with insulin and homeostasis model assessment of IR. In children, fT4 levels were negatively correlated with BMI and percentage of body fat (Table 1). CONCLUSIONS: The observed positive correlation between IR and fT3 in adolescents might indicate an interplay between thyroid function and IR. Ghrelin levels are negatively affected by IR but not directly associated with thyroid hormone concentrations. TABLE 1.Thyroid Function and Ghrelin and Leptin Levels in Obese Children and Adolescents With and Without Insulin ResistanceObese ChildrenObese AdolescentsIRNIR P IRNIR P n 20202020BMI, kg/m228.87 ± 3.8427.11 ± 4.53.12130.54 ± 4.7429.43 ± 3.87.678Body fat, %35.68 ± 4.7133.28 ± 4.98.15735.59 ± 6.0134.33 ± 5.14.461Homeostasis model assessment, IR5.00 ± 4.041.55 ± 0.64.0004.51 ± 1.531.80 ± 0.56.000Insulin, μIU/mL22.53 ± 15.027.33 ± 2.64.00020.04 ± 5.769.01 ± 2.65.000Ghrelin, pmol/L831.29 ± 379.19902.96 ± 360.49.355860.12 ± 289.891102.09 ± 366.10.043Leptin, ng/mL36.22 ± 14.9435.20 ± 23.43.30142.31 ± 21.8134.75 ± 17.93.221Thyrotropin, μIU/mL2.28 ± 1.222.15 ± 0.75.7792.20 ± 1.152.06 ± 1.24.659fT3, pg/mL4.61 ± 0.924.59 ± 0.64.9894.19 ± 0.684.12 ± 1.08.529fT4, ng/dL1.32 ± 0.141.37 ± 0.22.4951.22 ± 0.121.29 ± 0.17.398
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2007-2022IIIIII