Search Results - "Farlow, M R"

Impact of APOE in mild cognitive impairment by FARLOW, M. R, HE, Y, TEKIN, S, XU, J, LANE, R, CHARLES, H. C

“…The authors aimed to use baseline data of an ongoing large, prospective study in subjects with mild cognitive impairment (MCI) to investigate the impact of…”
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Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment by Nho, K, Corneveaux, J J, Kim, S, Lin, H, Risacher, S L, Shen, L, Swaminathan, S, Ramanan, V K, Liu, Y, Foroud, T, Inlow, M H, Siniard, A L, Reiman, R A, Aisen, P S, Petersen, R C, Green, R C, Jack, C R, Weiner, M W, Baldwin, C T, Lunetta, K, Farrer, L A, Furney, S J, Lovestone, S, Simmons, A, Mecocci, P, Vellas, B, Tsolaki, M, Kloszewska, I, Soininen, H, McDonald, B C, Farlow, M R, Ghetti, B, Huentelman, M J, Saykin, A J

“…Whole-exome sequencing of individuals with mild cognitive impairment, combined with genotype imputation, was used to identify coding variants other than the…”
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Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease by SIEMERS, E. R, QUINN, J. F, SATTERWHITE, J, GONZALES, C, DEAN, R. A, MAY, P. C, KAYE, J, FARLOW, M. R, PORSTEINSSON, A, TARIOT, P, ZOULNOUNI, P, GALVIN, J. E, HOLTZMAN, D. M, KNOPMAN, D. S

“…LY450139 dihydrate, a gamma-secretase inhibitor, was studied in a randomized, controlled trial of 70 patients with Alzheimer disease. Subjects were given 30 mg…”
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Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory by BARRAL, S, BIRD, T, WILSON, R. S, FOROUD, T, OTT, J, MAYEUX, R, GOATE, A, FARLOW, M. R, DIAZ-ARRASTIA, R, BENNETT, D. A, GRAFF-RADFORD, N, BOEVE, B. F, SWEET, R. A, STERN, Y

“…Several genome-wide association studies (GWAS) have associated variants in late-onset Alzheimer disease (LOAD) susceptibility genes; however, these single…”
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Adipose stromal cells-secreted neuroprotective media against neuronal apoptosis by Wei, X., Zhao, L., Zhong, J., Gu, H., Feng, D., Johnstone, B.H., March, K.L., Farlow, M.R., Du, Y.

“…Transplantation of pluripotent adipose stem/stromal cells (ASC) alleviates tissue damage and improves functional deficits in both stroke and cardiovascular…”
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Phenotypic variability in three families with valosin-containing protein mutation by Spina, S., Van Laar, A. D., Murrell, J. R., Hamilton, R. L., Kofler, J. K., Epperson, F., Farlow, M. R., Lopez, O. L., Quinlan, J., DeKosky, S. T., Ghetti, B.

“…Background and purpose The phenotype of IBMPFD [inclusion body myopathy with Paget's disease of the bone and frontotemporal dementia (FTD)] associated with…”
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Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration by Fontanilla, C.V, Ma, Z, Wei, X, Klotsche, J, Zhao, L, Wisniowski, P, Dodel, R.C, Farlow, M.R, Oertel, W.H, Du, Y

“…Abstract Parkinson's disease is associated with the loss of dopaminergic neurons in the substantia nigra and decreased striatal dopamine levels. We now report…”
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The role of choroid plexus in IVIG-induced beta-amyloid clearance by Gu, H, Zhong, Z, Jiang, W, Du, E, Dodel, R, Liu, J, Farlow, M.R, Zheng, W, Du, Y

“…Highlights • IVIG reduces brain Aβ levels. • IVIG induces Aβ efflux through the in vitro BCB membrane. • RAP and LRP1 siRNA significantly inhibit Aβ efflux…”
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Caffeic acid phenethyl ester extends survival of a mouse model of amyotrophic lateral sclerosis by Fontanilla, C.V, Wei, X, Zhao, L, Johnstone, B, Pascuzzi, R.M, Farlow, M.R, Du, Y

“…Abstract There is currently very limited effective pharmacological treatment for amyotrophic lateral sclerosis. Recent evidence suggests that caffeic acid…”
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Estrogen for Alzheimer's disease in women : Randomized, double-blind, placebo-controlled trial by HENDERSON, V. W, PAGANINI-HILL, A, MILLER, B. L, ELBLE, R. J, REYES, P. F, SHOUPE, D, MCCLEARY, C. A, KLEIN, R. A, HAKE, A. M, FARLOW, M. R

“…AD, the most prevalent cause of dementia, affects twice as many women as men. Therapeutic options are limited, but results of prior studies support the…”
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Cholesterol and APOE genotype interact to influence Alzheimer disease progression by EVANS, R. M, HUI, S, PERKINS, A, LAHIRI, D. K, POIRIER, J, FARLOW, M. R

“…In this retrospective analysis of 443 Alzheimer disease (AD) patients from a 30-week tacrine trial, change in Alzheimer's Disease Assessment Scale score from…”
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Association of statin use with cognitive decline in elderly African Americans by SZWAST, S. J, HENDRIE, H. C, HALL, K. S, LANE, K. A, GAO, S, TAYLOR, S. E, UNVERZAGT, F, MURRELL, J, DEEG, M, OGUNNIYI, A, FARLOW, M. R

“…Previously reported associations between statin use and incident dementia or cognitive decline have been inconsistent. We report the results from a 3-year…”
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Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity by Wei, X, Ma, Z, Fontanilla, C.V, Zhao, L, Xu, Z.C, Taggliabraci, V, Johnstone, B.H, Dodel, R.C, Farlow, M.R, Du, Y

“…Abstract Caffeic acid phenethyl ester (CAPE) is an active component of propolis obtained from honeybee hives and is found to have the following properties:…”
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Minocycline prevents gentamicin-induced ototoxicity by inhibiting p38 MAP kinase phosphorylation and caspase 3 activation by Wei, X., Zhao, L., Liu, J., Dodel, R.C., Farlow, M.R., Du, Y.

“…Aminoglycosides are commonly used antibiotics that often induce ototoxicity leading to permanent hair cell loss and hearing impairment. We hereby examined…”
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Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease : A population-based study of African Americans by EVANS, R. M, EMSLEY, C. L, GAO, S, SAHOTA, A, HALL, K. S, FARLOW, M. R, HENDRIE, H

“…A significant interaction among total serum cholesterol (TC), APOE genotype, and AD risk was found in a population-based study of elderly African Americans…”
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Association of an interleukin 1α polymorphism with Alzheimer's disease by DU, Y, DODEL, R. C, HAKE, A, GASSER, T, OERTEL, W. H, GRIFFIN, W. S. T, PAUL, S. M, FARLOW, M. R, EASTWOOD, B. J, BALES, K. R, GAO, F, LOHMÜLLER, F, MÜLLER, U, KURZ, A, ZIMMER, R, EVANS, R. M

“…Retrospective epidemiologic studies suggest that individuals exposed to anti-inflammatory agents such as nonsteroidal anti-inflammatory drugs have a lower…”
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A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease by ROGERS, S. L, FARLOW, M. R, DOODY, R. S, MOHS, R, FRIEDHOFF, L. T

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Safety and tolerability of rivastigmine transdermal patch compared with rivastigmine capsules in patients switched from donepezil: data from three clinical trials by Sadowsky, C H, Farlow, M R, Meng, X, Olin, J T

“…To compare the safety and tolerability of switching patients with mild-to-moderate Alzheimer's disease from donepezil to either rivastigmine capsule or…”
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Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease by FARLOW, M. R, LAHIRI, D. K, POIRIER, J, DAVIGNON, J, SCHNEIDER, L, HUI, S. L

“…We studied the effects of apolipoprotein E (APOE) genotype and gender on clinical response to tacrine in patients with mild to moderate Alzheimer's disease…”
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A randomized controlled trial of prednisone in Alzheimer's disease by AISEN, P. S, DAVIS, K. L, THAL, L. J, BERG, J. D, SCHAFER, K, CAMPBELL, K, THOMAS, R. G, WEINER, M. F, FARLOW, M. R, SANO, M, GRUNDMAN, M

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