Search Results - "Farizatto, Karen L.G."

Distinct and dementia‐related synaptopathy in the hippocampus after military blast exposures by Almeida, Michael F., Piehler, Thuvan, Carstens, Kelly E., Zhao, Meilan, Samadi, Mahsa, Dudek, Serena M., Norton, Christopher J., Parisian, Catherine M., Farizatto, Karen L.G., Bahr, Ben A.

“…Explosive shockwaves, and other types of blast exposures, are linked to injuries commonly associated with military service and to an increased risk for the…”
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The Role of Lysosomes in a Broad Disease-Modifying Approach Evaluated across Transgenic Mouse Models of Alzheimer's Disease and Parkinson's Disease and Models of Mild Cognitive Impairment by Hwang, Jeannie, Estick, Candice M, Ikonne, Uzoma S, Butler, David, Pait, Morgan C, Elliott, Lyndsie H, Ruiz, Sarah, Smith, Kaitlan, Rentschler, Katherine M, Mundell, Cary, Almeida, Michael F, Stumbling Bear, Nicole, Locklear, James P, Abumohsen, Yara, Ivey, Cecily M, Farizatto, Karen L G, Bahr, Ben A

“…Many neurodegenerative disorders have lysosomal impediments, and the list of proposed treatments targeting lysosomes is growing. We investigated the role of…”
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Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to Nicotine by Chadi, Gerson, Coelho, Emerson F., Farizatto, Karen L. G., Fior-Chadi, Debora R., Ferrari, Merari F. R.

“…Considering that nicotine instantly interacts with central and peripheral nervous systems promoting cardiovascular effects after tobacco smoking, we evaluated…”
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Astrocyte-synapse interactions during brain development by Farizatto, Karen L.G., Baldwin, Katherine T.

“…Bidirectional communication between astrocytes and neurons is essential for proper brain development. Astrocytes, a major glial cell type, are morphologically…”
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Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies by Almeida, Michael F, Farizatto, Karen L G, Almeida, Renato S, Bahr, Ben A

“…Unhealthy lifestyle choices, poor diet, and aging can have negative influences on cognition, gradually increasing the risk for mild cognitive impairment (MCI)…”
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Early Synaptic Alterations and Selective Adhesion Signaling in Hippocampal Dendritic Zones Following Organophosphate Exposure by Farizatto, Karen L. G., Almeida, Michael F., Long, Ronald T., Bahr, Ben A.

“…Organophosphates account for many of the world’s deadliest poisons. They inhibit acetylcholinesterase causing cholinergic crises that lead to seizures and…”
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Excitotoxic stimulation activates distinct pathogenic and protective expression signatures in the hippocampus by Caba, Ebru, Sherman, Marcus D., Farizatto, Karen L. G., Alcira, Britney, Wang, Hsin‐wei, Giardina, Charles, Shin, Dong‐Guk, Sandefur, Conner I., Bahr, Ben A.

“…Excitotoxic events underlying ischaemic and traumatic brain injuries activate degenerative and protective pathways, particularly in the hippocampus. To…”
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Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology by Lamani, Manjunath, Malamas, Michael S., Farah, Shrouq I., Shukla, Vidyanand G., Almeida, Michael F., Weerts, Catherine M., Anderson, Joseph, Wood, JodiAnne T., Farizatto, Karen L.G., Bahr, Ben A., Makriyannis, Alexandros

“…[Display omitted] FAAH inhibitors offer safety advantages by augmenting the anandamide levels “on demand” to promote neuroprotective mechanisms without the…”
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Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways by Farizatto, Karen L G, Ikonne, Uzoma S, Almeida, Michael F, Ferrari, Merari F R, Bahr, Ben A

“…Impaired protein clearance likely increases the risk of protein accumulation disorders including Alzheimer's disease (AD). Protein degradation through the…”
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Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon by Farizatto, Karen L. G., McEwan, Sara A., Naidoo, Vinogran, Nikas, Spyros P., Shukla, Vidyanand G., Almeida, Michael F., Byrd, Aaron, Romine, Heather, Karanian, David A., Makriyannis, Alexandros, Bahr, Ben A.

“…The anticholinesterase paraoxon (Pxn) is related to military nerve agents that increase acetylcholine levels, trigger seizures, and cause excitotoxic damage in…”
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Rotenone-Dependent Changes of Anterograde Motor Protein Expression and Mitochondrial Mobility in Brain Areas Related to Neurodegenerative Diseases by Melo, Thaiany Q., D’unhao, Aline M., Martins, Stephanie A., Farizatto, Karen L. G., Chaves, Rodrigo S., Ferrari, Merari F. R.

“…The presence of protein aggregates is common in neurodegenerative disorders; however, the real cause and effect of these aggregates during neurodegeneration is…”
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Dynein c1h1, dynactin and syntaphilin expression in brain areas related to neurodegenerative diseases following exposure to rotenone by Chaves, Rodrigo S, Melo, Thaiany Q, D'Unhao, Aline M, Farizatto, Karen L G, Ferrari, Merari F R

“…Neurodegeneration is often accompanied by protein inclusions which may interfere with cell physiology. On the other hand, alteration in intracellular…”
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