Search Results - "Farinella, Riccardo"
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Genetically predicted gut bacteria, circulating bacteria-associated metabolites and pancreatic ductal adenocarcinoma: a Mendelian randomisation study
Published in Scientific reports (24-10-2024)“…Pancreatic ductal adenocarcinoma (PDAC) has high mortality and rising incidence rates. Recent data indicate that the gut microbiome and associated metabolites…”
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Polymorphic variants in Sweet and Umami taste receptor genes and birthweight
Published in Scientific reports (02-03-2021)“…The first thousand days of life from conception have a significant impact on the health status with short, and long-term effects. Among several anthropometric…”
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Maternal anthropometric variables and clinical factors shape neonatal microbiome
Published in Scientific reports (21-02-2022)“…Recent studies indicate the existence of a complex microbiome in the meconium of newborns that plays a key role in regulating many host health-related…”
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Role of pancreatic ductal adenocarcinoma risk factors in intraductal papillary mucinous neoplasm progression
Published in Frontiers in oncology (06-06-2023)“…Pancreatic ductal adenocarcinoma (PDAC) is lethal due to its late diagnosis and lack of successful treatments. A possible strategy to reduce its death burden…”
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Role of OPRM1, clinical and anthropometric variants in neonatal pain reduction
Published in Scientific reports (27-04-2020)“…An increased awareness on neonatal pain-associated complications has led to the development of pain scales adequate to assess the level of pain experienced by…”
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The genetic variant SLC2A1 -rs1105297 is associated with the differential analgesic response to a glucose-based treatment in newborns
Published in Pain (Amsterdam) (01-03-2024)“…Neonatal pain is a critical issue in clinical practice. The oral administration of glucose-based solutions is currently one of the most common and effective…”
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The local environment and germline genetic variation predict cancer risk in the UK Biobank prospective cohort
Published in Environmental research (15-01-2024)“…There is a growing body of evidence on the effect of the local environment exposure on cancer susceptibility. Nonetheless, several of the associations remain…”
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Long or short? Telomere length and pancreatic cancer and its precursor lesions, a narrative review
Published in Mutagenesis (17-11-2023)“…Pancreatic ductal adenocarcinoma (PDAC) is the most common and lethal form of pancreatic cancer, with a survival approaching only 11% at 5 years after…”
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Analysis of exposome and genetic variability suggests stress as a major contributor for development of pancreatic ductal adenocarcinoma
Published in Digestive and liver disease (01-06-2024)“…The current knowledge on pancreatic ductal adenocarcinoma (PDAC) risk factors is limited and no study has comprehensively tested the exposome in combination…”
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Association between a polymorphic variant in the CDKN2B‐AS1/ANRIL gene and pancreatic cancer risk
Published in International journal of cancer (15-07-2023)“…Genes carrying high‐penetrance germline mutations may also be associated with cancer susceptibility through common low‐penetrance genetic variants. To increase…”
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The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer
Published in Critical reviews in oncology/hematology (01-06-2023)“…Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so…”
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A scan of all coding region variants of the human genome, identifies 13q12.2-rs9579139 and 15q24.1-rs2277598 as novel risk loci for pancreatic ductal adenocarcinoma
Published in Carcinogenesis (New York) (02-12-2023)“…Abstract Coding sequence variants comprise a small fraction of the germline genetic variability of the human genome. However, they often cause deleterious…”
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A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma
Published in Mutagenesis (12-04-2024)“…Pleiotropic variants (i.e., genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants…”
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Physical Activity, Sedentary Behavior, and Pancreatic Cancer Risk: A Mendelian Randomization Study
Published in Journal of the Endocrine Society (19-02-2024)“…Abstract Pancreatic cancer is currently the seventh leading cause of cancer death worldwide. Understanding whether modifiable factors increase or decrease the…”
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