Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows

Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows

The aim of this study was to determine the effect of growth hormone receptor (GHR) AluI, insulin-like growth factor type 1 (IGF-I) SnaBI, and signal transducer and activator 5A (STAT5A) BstEII polymorphisms in the reproductive performance of Holstein dairy cows and the frequency of this genotypes in...

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Bibliographic Details
Published in:Theriogenology Vol. 88; pp. 67 - 72
Main Authors: Hax, Lucas Teixeira, Schneider, Augusto, Jacometo, Carolina Bespalhok, Mattei, Patrícia, da Silva, Thaís Casarin, Farina, Géssica, Corrêa, Marcio Nunes
Format: Journal Article
Language:English
Published: United States Elsevier Inc 15-01-2017
Subjects:
Animals
Cattle - genetics
Cattle - physiology
Fertility - genetics
Gene Expression Regulation - physiology
Genotype
GHR
IGF-I
Insulin-Like Growth Factor I - genetics
Insulin-Like Growth Factor I - metabolism
Polymorphism, Genetic
Receptors, Somatotropin - genetics
Receptors, Somatotropin - metabolism
Reproduction
SNP
STAT5 Transcription Factor - genetics
STAT5 Transcription Factor - metabolism
STAT5A
GHR
STAT5A
IGF-I
Reproduction
SNP
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Summary:The aim of this study was to determine the effect of growth hormone receptor (GHR) AluI, insulin-like growth factor type 1 (IGF-I) SnaBI, and signal transducer and activator 5A (STAT5A) BstEII polymorphisms in the reproductive performance of Holstein dairy cows and the frequency of this genotypes in cows managed in different systems. This work studied 381 and 506 Holstein cows from semiextensive and intensive systems, respectively. The frequency of genotypes GHRAluI (+/−), IGF-ISnaBI (−/−) and (+/−), and STAT5ABstEII (−/−) was higher in animals from semiextensive system, whereas the frequency of the genotypes GHRAluI (+/+) and IGF-ISnaBI (+/+) was higher in animals from intensive system (P < 0.05). In the intensive system, cows from the STAT5ABstEII (−/−) genotype had a longer calving-first heat interval (P = 0.03). In conclusion, there was no association between the genotypes of GHRAluI and IGF-ISnaBI and fertility of Holstein cows raised in semiextensive or intensive regimes, although the genotype frequencies of the evaluated polymorphisms were different between the studied systems. The STAT5ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system, indicating that this gene could be a molecular marker for genetic selection to improve reproductive performance.
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ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2016.03.044