Search Results - "Farina, Antonietta Rosella"

Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer by Farina, Antonietta Rosella, Cappabianca, Lucia, Sebastiano, Michela, Zelli, Veronica, Guadagni, Stefano, Mackay, Andrew Reay

“…Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and progression. In this review, we update currents concepts of…”
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Doxorubicin-Induced TrkAIII Activation: A Selection Mechanism for Resistant Dormant Neuroblastoma Cells by Cappabianca, Lucia, Sebastiano, Michela, Ruggieri, Marianna, Sbaffone, Maddalena, Zelli, Veronica, Farina, Antonietta Rosella, Mackay, Andrew Reay

“…Patients with advanced neuroblastoma (NB) receive multimodal clinical therapy, including the potent anthracycline chemotherapy drug doxorubicin (Dox). The…”
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Molecular Characterization and Inhibition of a Novel Stress-Induced Mitochondrial Protecting Role for Misfolded TrkAIII in Human SH-SY5Y Neuroblastoma Cells by Cappabianca, Lucia, Ruggieri, Marianna, Sebastiano, Michela, Sbaffone, Maddalena, Martelli, Ilaria, Ruggeri, Pierdomenico, Di Padova, Monica, Farina, Antonietta Rosella, Mackay, Andrew Reay

“…Pediatric neuroblastomas (NBs) are heterogeneous, aggressive, therapy-resistant embryonal tumors that originate from cells of neural crest origin committed to…”
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Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma by Cappabianca, Lucia, Farina, Antonietta Rosella, Di Marcotullio, Lucia, Infante, Paola, De Simone, Daniele, Sebastiano, Michela, Mackay, Andrew Reay

“…Identification of novel cancer-associated splice variants is of potential diagnostic, prognostic and therapeutic importance. NF-Y transcription factor is…”
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The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII by Farina, Antonietta Rosella, Cappabianca, Lucia, Ruggeri, Pierdomenico, Gneo, Luciana, Pellegrini, Cristina, Fargnoli, Maria-Concetta, Mackay, Andrew Reay

“…Oncogenes derived from the neurotrophin receptor tropomyosin-related kinase TrkA act as drivers in sub-populations of a wide-range of human cancers. This,…”
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Multidisciplinary Treatment, Including Locoregional Chemotherapy, for Merkel-Polyomavirus-Positive Merkel Cell Carcinomas: Perspectives for Patients Exhibiting Oncogenic Alternative Δ exon 6-7 TrkAIII Splicing of Neurotrophin Receptor Tropomyosin-Related Kinase A by Guadagni, Stefano, Farina, Antonietta Rosella, Cappabianca, Lucia Annamaria, Sebastiano, Michela, Maccarone, Rita, Zelli, Veronica, Clementi, Marco, Chiominto, Alessandro, Bruera, Gemma, Ricevuto, Enrico, Fiorentini, Giammaria, Sarti, Donatella, Mackay, Andrew Reay

“…Merkel cell carcinomas (MCCs) are rare, aggressive, cutaneous neuroendocrine tumours, approximately 80% of which are caused by the genomic integration of…”
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A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target by Cappabianca, Lucia, Guadagni, Stefano, Maccarone, Rita, Sebastiano, Michela, Chiominto, Alessandro, Farina, Antonietta Rosella, Mackay, Andrew Reay

“…Merkel cell carcinomas (MCCs) are rare, aggressive, therapeutically-challenging skin tumours that are increasing in incidence and have poor survival rates. The…”
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Nutraceutical Preventative and Therapeutic Potential in Neuroblastoma: From Pregnancy to Early Childhood by Sbaffone, Maddalena, Ruggieri, Marianna, Sebastiano, Michela, Mackay, Andrew Reay, Zelli, Veronica, Farina, Antonietta Rosella, Cappabianca, Lucia Annamaria

“…Neuroblastoma (NB) is a highly malignant embryonic extracranial solid tumor that arises from sympathoadrenal neuroblasts of neural crest origin. In addition to…”
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A Study of Alternative TrkA Splicing Identifies TrkAIII as a Novel Potentially Targetable Participant in PitNET Progression by Sbaffone, Maddalena, Jaffrain-Rea, Marie-Lise, Cappabianca, Lucia, Carbonara, Francesca, Gianno, Francesca, Feola, Tiziana, Ruggieri, Marianna, Zelli, Veronica, Maccarone, Rita, Guadagni, Stefano, Clementi, Marco, Arcella, Antonietta, Esposito, Vincenzo, Carozza, Giulia, Martelli, Ilaria, Farina, Antonietta Rosella, Mackay, Andrew Reay

“…Pituitary neuroendocrine tumors (PitNETs) are generally benign but comprise an aggressive, invasive, therapy-resistant, metastatic subset, underpinning a need…”
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The Alternative TrkAIII Splice Variant Targets the Centrosome and Promotes Genetic Instability by Farina, Antonietta Rosella, Tacconelli, Antonella, Cappabianca, Lucia, Cea, Gesilia, Panella, Sonia, Chioda, Antonella, Romanelli, Alessandra, Pedone, Carlo, Gulino, Alberto, Mackay, Andrew Reay

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Gelatinase B/MMP-9 in Tumour Pathogenesis and Progression by Farina, Antonietta Rosella, Mackay, Andrew Reay

“…Since its original identification as a leukocyte gelatinase/type V collagenase and tumour type IV collagenase, gelatinase B/matrix metalloproteinase (MMP)-9 is…”
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A Prospective Study of Intraarterial Infusion Chemotherapy in Advanced Wild-Type BRAF Melanoma Patients by Guadagni, Stefano, Zoras, Odysseas, Fiorentini, Giammaria, Masedu, Francesco, Lasithiotakis, Konstantinos, Sarti, Donatella, Farina, Antonietta Rosella, Mackay, Andrew Reay, Clementi, Marco

“…•Treatment strategies for advanced cutaneous melanoma patients, ineligible for novel target and immunotherapies, remain a challenge.•In a BRAF wild-type…”
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TrkAIII signals endoplasmic reticulum stress to the mitochondria in neuroblastoma cells, resulting in glycolytic metabolic adaptation by Farina, Antonietta Rosella, Cappabianca, Lucia, Gneo, Luciana, Ruggeri, Pierdomenico, Mackay, Andrew Reay

“…Alternative TrkAIII splicing characterises advanced stage metastatic disease and post-therapeutic relapse in neuroblastoma (NB), and in NB models TrkAIII…”
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Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting by Farina, Antonietta Rosella, Cappabianca, Lucia Annamaria, Zelli, Veronica, Sebastiano, Michela, Mackay, Andrew Reay

“…Pediatric neuroblastomas (NBs) are heterogeneous, aggressive, therapy-resistant embryonal tumours that originate from cells of neural crest (NC) origin and in…”
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Retrograde TrkAIII transport from ERGIC to ER: a re-localisation mechanism for oncogenic activity by Farina, Antonietta Rosella, Cappabianca, Lucia, Ruggeri, Pierdomenico, Gneo, Luciana, Maccarone, Rita, Mackay, Andrew Reay

“…In human SH-SY5Y neuroblastoma (NB) cells, nascent immature N-glycosylated 110kDa TrkA moves rapidly from the endoplasmic reticulum (ER) to the Golgi Network…”
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TRAIL induces pro-apoptotic crosstalk between the TRAIL-receptor signaling pathway and TrkAIII in SH-SY5Y cells, unveiling a potential therapeutic "Achilles heel" for the TrkAIII oncoprotein in neuroblastoma by Gneo, Luciana, Ruggeri, Pierdomenico, Cappabianca, Lucia, Farina, Antonietta Rosella, Di Ianni, Natalia, Mackay, Andrew Reay

“…TrkAIII expression in neuroblastoma (NB) associates with advanced stage disease, worse prognosis, post therapeutic relapse, and in NB models TrkAIII exhibits…”
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Reconstitution of TIMP-2 expression in SH-SY5Y neuroblastoma cells by 5-azacytidine is mediated transcriptionally by NF-Y through an inverted CCAAT site by Cappabianca, Lucia, Farina, Antonietta Rosella, Tacconelli, Antonella, Mantovani, Roberto, Gulino, Alberto, Mackay, Andrew Reay

“…Advanced stage neuroblastomas (NB) exhibit a tissue inhibitor of metalloproteinase (TIMP)-2/matrix metalloproteinase (MMP) imbalance, considered a prerequisite…”
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Prostaglandin E2Inhibits the Interleukin-2 Promoter Activity through Down-Regulation of the Oct-Dependent Transcription of the Octamer Motif by Felli, Maria Pia, Moschella, Clementina, Farina, Antonietta Rosella, Alesse, Edoardo, Screpanti, Isabella, Teti, Diana, Frati, Luigi, Gulino, Alberto

“…Prostaglandins, mainly those of the E series (PGE), are modulators of immune responses. Indeed PGE2inhibits T cell activation and the transcription of the…”
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Prostaglandin E2 inhibits the interleukin-2 promoter activity through down-regulation of the Oct-dependent transcription of the octamer motif by Felli, M P, Moschella, C, Farina, A R, Alesse, E, Screpanti, I, Teti, D, Frati, L, Gulino, A

“…Prostaglandins, mainly those of the E series (PGE), are modulators of immune responses. Indeed PGE2 inhibits T cell activation and the transcription of the…”
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