Search Results - "Farina, Antonietta R"

Circulating tumour cell gene expression and chemosensitivity analyses: predictive accuracy for response to multidisciplinary treatment of patients with unresectable refractory recurrent rectal cancer or unresectable refractory colorectal cancer liver metastases by Guadagni, Stefano, Masedu, Francesco, Fiorentini, Giammaria, Sarti, Donatella, Fiorentini, Caterina, Guadagni, Veronica, Apostolou, Panagiotis, Papasotiriou, Ioannis, Parsonidis, Panagiotis, Valenti, Marco, Ricevuto, Enrico, Bruera, Gemma, Farina, Antonietta R, Mackay, Andrew R, Clementi, Marco

“…Background Patients with unresectable recurrent rectal cancer (RRC) or colorectal cancer (CRC) with liver metastases, refractory to at least two lines of…”
Get full text

The TrkAIII oncoprotein inhibits mitochondrial free radical ROS-induced death of SH-SY5Y neuroblastoma cells by augmenting SOD2 expression and activity at the mitochondria, within the context of a tumour stem cell-like phenotype by Ruggeri, Pierdomenico, Farina, Antonietta R, Di Ianni, Natalia, Cappabianca, Lucia, Ragone, Marzia, Ianni, Giulia, Gulino, Alberto, Mackay, Andrew R

“…The developmental and stress-regulated alternative TrkAIII splice variant of the NGF receptor TrkA is expressed by advanced stage human neuroblastomas (NBs),…”
Get full text

The Alternative TrkAIII Splice Variant, a Targetable Oncogenic Participant in Human Cutaneous Malignant Melanoma by Cappabianca, Lucia, Zelli, Veronica, Pellegrini, Cristina, Sebastiano, Michela, Maccarone, Rita, Clementi, Marco, Chiominto, Alessandro, Ruggeri, Pierdomenico, Cardelli, Ludovica, Ruggieri, Marianna, Sbaffone, Maddalena, Fargnoli, Maria-Concetta, Guadagni, Stefano, Farina, Antonietta R, Mackay, Andrew R

“…Post-therapeutic relapse, poor survival rates and increasing incidence justify the search for novel therapeutic targets and strategies in cutaneous malignant…”
Get full text

Alternative TrkAIII splicing: a potential regulated tumor-promoting switch and therapeutic target in neuroblastoma by Tacconelli, Antonella, Farina, Antonietta R, Cappabianca, Lucia, Gulino, Alberto, Mackay, Andrew R

“…An association between elevated tyrosine kinase receptor (Trk)-A expression and better prognosis; the absence of mutation-activated TrkA oncogenes; the…”
Get more information

Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells by Farina, Antonietta R., Cappabianca, Lucia, DeSantis, Giuseppina, Ianni, Natalia Di, Ruggeri, Pierdomenico, Ragone, Marzia, Merolle, Stefania, Tonissen, Kathryn F., Gulino, Alberto, Mackay, Andrew R.

“…► We model the effect of Trx-1 on MMP-9 expression and involvement in breast cancer. ► Trx-1 stimulates MMP-9 expression by increasing NF-κB mediated…”
Get full text

TrkAIII: A Novel Hypoxia-regulated Alternative TrkA Splice Variant of Potential Physiological and Pathological Importance by Tacconelli, Antonella, Farina, Antonietta R., Cappabianca, Lucia, Gulino, Alberto, Mackay, Andrew R.

“…Nerve growth factor receptor TrkA is critical for development and maturation of central and peripheral nervous systems, regulating proliferation,…”
Get full text

TrkA alternative splicing: A regulated tumor-promoting switch in human neuroblastoma by Tacconelli, Antonella, Farina, Antonietta R., Cappabianca, Lucia, DeSantis, Giuseppina, Tessitore, Alessandra, Vetuschi, Antonella, Sferra, Roberta, Rucci, Nadia, Argenti, Beatrice, Screpanti, Isabella, Gulino, Alberto, Mackay, Andrew R.

“…We identify a novel alternative TrkA splice variant, TrkAIII, with deletion of exons 6, 7, and 9 and functional extracellular IG-C1 and N-glycosylation…”
Get full text

Constitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin by Farina, Antonietta R., Cappabianca, Lucia, Ruggeri, Pierdomenico, Di Ianni, Natalia, Ragone, Marzia, Merolle, Stefania, Sano, Kimihiko, Stracke, Mary L., Horowitz, Jonathan M., Gulino, Alberto, Mackay, Andrew R.

“…► We report a novel transcriptional mechanism for autotaxin expression in human neuroblastoma cells. ► This mechanism is common to Nmyc amplified and…”
Get full text

Alendronate promotes plasmin-mediated MMP-9 inactivation by exposing cryptic plasmin degradation sites within the MMP-9 catalytic domain by Farina, Antonietta R., Cappabianca, Lucia, Di Ianni, Natalia, Ruggeri, Pierdomenico, Ragone, Marzia, Merolle, Stefania, Gulino, Alberto, Mackay, Andrew R.

“…► We report the inhibitory effect of plasmin in the presence of Alendronate upon proMMP-9. ► Alendronate promotes non-reversible plasmin-mediated MMP-9…”
Get full text

TrkAIII Promotes Microtubule Nucleation and Assembly at the Centrosome in SH-SY5Y Neuroblastoma Cells, Contributing to an Undifferentiated Anaplastic Phenotype by Mackay, Andrew R., Ianni, Giulia, Ragone, Marzia, Ruggeri, Pierdomenico, Cappabianca, Lucia, Di Ianni, Natalia, Farina, Antonietta R., Gulino, Alberto

“…The alternative TrkAIII splice variant is expressed by advanced stage human neuroblastomas (NBs) and exhibits oncogenic activity in NB models. In the present…”
Get full text

TrkAIII expression in the thymus by Tacconelli, Antonella, Farina, Antonietta R, Cappabianca, Lucia, Cea, Gesilia, Panella, Sonia, Chioda, Antonella, Gallo, Rita, Cinque, Benedetta, Sferra, Roberta, Vetuschi, Antonella, Campese, Antonio Francesco, Screpanti, Isabella, Gulino, Alberto, Mackay, Andrew R

“…Abstract The alternative TrkAIII splice variant is expressed by murine and human thymus. Alternative TrkAIII splicing predominates in postembryonic day E13…”
Get full text

Thioredoxin inhibits microvascular endothelial capillary tubule formation by Farina, Antonietta R, Tacconelli, Antonella, Cappabianca, Lucia, DeSantis, Giuseppina, Gulino, Alberto, Mackay, Andrew R

“…Thioredoxin (Trx) inhibited human HMEC-1 dermal microvascular endothelial cell capillary tubule forming capacity in a Matrigel based assay in vitro. Inhibition…”
Get full text

Tissue inhibitor of metalloproteinase-2 protection of matrix metalloproteinase-2 from degradation by plasmin is reversed by divalent cation chelator EDTA and the bisphosphonate alendronate by FARINA, A. R, TACCONELLI, A, TETI, A, GULINO, A, MACKAY, A. R

“…The degradation of tissue inhibitor of metalloproteinase (TIMP)-free matrix metalloproteinase (MMP)-2 to proteolytically inactive fragments by plasmin was…”
Get full text

Thioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK‐N‐SH neuroblastoma cell invasion by Farina, Antonietta R., Tacconelli, Antonella, Cappabianca, Lucia, Masciulli, Maria‐Paola, Holmgren, Arne, Beckett, Geoffery J., Gulino, Alberto, Mackay, Andrew R.

“…Thioredoxin (Trx) inhibited tissue inhibitor of metalloproteinase (TIMP)‐1 and TIMP‐2 activity with an approximate IC50 of 0.3 µm, matrix metalloproteinase…”
Get full text

Inhibition of human MDA‐MB‐231 breast cancer cell invasion by matrix metalloproteinase 3 involves degradation of plasminogen by Farina, Antonietta R., Tacconelli, Antonella, Cappabianca, Lucia, Gulino, Alberto, Mackay, Andrew R

“…Matrix metalloproteinase (MMP)‐3 inhibited human MDA‐MB‐231 breast cancer cell invasion through reconstituted basement membrane in vitro. Inhibition of…”
Get full text

Transcriptional Modulation of the Human Intercellular Adhesion Molecule Gene I (ICAM-1) by Retinoic Acid in Melanoma Cells by Cilenti, Lucia, Toniato, Elena, Ruggiero, Paolo, Fusco, Carlo, Farina, Antonietta R., Tiberio, Antonella, Hayday, Adrian C., Gulino, Alberto, Frati, Luigi, Martinotti, Stefano

“…Retinoids play an important role as differentiating agents in a variety of normal and neoplastic cells and have been reported to induce ICAM-1 levels in…”
Get full text

All-trans-retinoic acid induces nuclear factor κB activation and matrix metalloproteinase-9 expression and enhances basement membrane invasivity of differentiation-resistant human SK-N-BE 9N neuroblastoma cells by FARINA, Antonietta R, MASCIULLI, Maria-Paola, TACCONELLI, Antonella, CAPPABIANCA, Lucia, DE SANTIS, Giuseppina, GULINO, Alberto, MACKAY, Andrew R

Get full text

Transforming growth factor‐β1 enhances the invasiveness of human MDA‐MB‐231 breast cancer cells by up‐regulating urokinase activity by Farina, Antonietta R., Coppa, Anna, Tiberio, Antonella, Tacconelli, Antonella, Turco, Alessandra, Colletta, Gulia, Gulino, Alberto, Mackay, Andrew R.

“…Transforming growth factor‐beta (TGFβ1) enhances human MDA‐MB‐231 breast tumour cell invasion of reconstituted basement membrane in vitro but does not inhibit…”
Get full text

Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements by VACCA, A, FELLI, M. P, FARINA, A. R, MARTINOTTI, S, MARODER, M, SCREPANTI, I, MECO, D, PETRONGALI, E, FRATI, L, GILINO, A

“…The immunosuppressant hormone dexamethasone (Dex) interferes with T cell-specific signals activating the enhancer sequences directing interleukin 2 (IL-2)…”
Get full text

TrkA alternative splicing by Tacconelli, Antonella, Farina, Antonietta R., Cappabianca, Lucia, DeSantis, Giuseppina, Tessitore, Alessandra, Vetuschi, Antonella, Sferra, Roberta, Rucci, Nadia, Argenti, Beatrice, Screpanti, Isabella, Gulino, Alberto, Mackay, Andrew R.

Get full text