Search Results - "Farin, F."

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche by Farin, Henner F., Jordens, Ingrid, Mosa, Mohammed H., Basak, Onur, Korving, Jeroen, Tauriello, Daniele V. F., de Punder, Karin, Angers, Stephane, Peters, Peter J., Maurice, Madelon M., Clevers, Hans

“…Generation of an epitope-tagged, functional Wnt3 knock-in allele, the signal produced by Paneth cells to regulate intestinal stem cells. Wnt signalling in the…”
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Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids by Michels, Birgitta E., Mosa, Mohammed H., Streibl, Barbara I., Zhan, Tianzuo, Menche, Constantin, Abou-El-Ardat, Khalil, Darvishi, Tahmineh, Członka, Ewelina, Wagner, Sebastian, Winter, Jan, Medyouf, Hind, Boutros, Michael, Farin, Henner F.

“…Colorectal cancer (CRC) is characterized by prominent genetic and phenotypic heterogeneity between patients. To facilitate high-throughput genetic testing and…”
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Plasticity within stem cell hierarchies in mammalian epithelia by Tetteh, Paul W, Farin, Henner F, Clevers, Hans

“…Highlights • Committed epithelial cells can dedifferentiate into stem cells during regeneration. • Such cells functionally resemble quiescent stem cells. •…”
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Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters by Tetteh, Paul W., Basak, Onur, Farin, Henner F., Wiebrands, Kay, Kretzschmar, Kai, Begthel, Harry, van den Born, Maaike, Korving, Jeroen, de Sauvage, Frederic, van Es, Johan H., van Oudenaarden, Alexander, Clevers, Hans

“…Intestinal crypts display robust regeneration upon injury. The relatively rare secretory precursors can replace lost stem cells, but it is unknown if the…”
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Strategies for genetic manipulation of adult stem cell-derived organoids by Menche, Constantin, Farin, Henner F.

“…Organoid technology allows the expansion of primary epithelial cells from normal and diseased tissues, providing a unique model for human (patho)biology. In a…”
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Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung by Lüdtke, Timo H., Rudat, Carsten, Wojahn, Irina, Weiss, Anna-Carina, Kleppa, Marc-Jens, Kurz, Jennifer, Farin, Henner F., Moon, Anne, Christoffels, Vincent M., Kispert, Andreas

“…Numerous signals drive the proliferative expansion of the distal endoderm and the underlying mesenchyme during lung branching morphogenesis, but little is…”
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Alterations in Breast Cancer Biomarkers Following Neoadjuvant Therapy by Mohan, Srivarshini Cherukupalli, Walcott-Sapp, Sarah, Lee, Minna K., Srour, Marissa K., Kim, Sungjin, Amersi, Farin F., Giuliano, Armando E., Chung, Alice P.

“…Introduction Biomarker changes in patients with residual disease (RD) after neoadjuvant systemic therapy (NAT) have unclear consequences. This study examined…”
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Human colon organoids reveal distinct physiologic and oncogenic Wnt responses by Michels, Birgitta E, Mosa, Mohammed H, Grebbin, Britta M, Yepes, Diego, Darvishi, Tahmineh, Hausmann, Johannes, Urlaub, Henning, Zeuzem, Stefan, Kvasnicka, Hans M, Oellerich, Thomas, Farin, Henner F

“…Constitutive Wnt activation upon loss of ( ) acts as main driver of colorectal cancer (CRC). Targeting Wnt signaling has proven difficult because the pathway…”
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Practice Patterns of Antibiotic Prophylaxis in Patients Undergoing Mastectomy: A Survey of Members of the American Society of Breast Surgeons by Sattar, Abida K., Shahzad, Hania, Masroor, Taleaa, Martins, Russell Seth, Zahid, Nida, Amersi, Farin F.

“…Background Surgical site infections after breast surgery range from 1 to 16%. Both the American Society of Breast Surgeons (ASBrS) and the American Association…”
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Staged Nipple Delay Procedure Expands Candidacy for Nipple-Sparing Mastectomy by Wang, Xuanji, Jackson, Jordan, Weed, Christina, Boyle, Marissa K, Amersi, Farin F, Mirocha, James, Giuliano, Armando E, Chung, Alice P

“…Nipple delay (ND) is a staged procedure that improves nipple-areolar complex (NAC) viability in nipple-sparing mastectomy (NSM) patients who are high-risk for…”
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ASO Visual Abstract: Practice Patterns of Antibiotic Prophylaxis in Patients Undergoing Mastectomy—A Survey of Members of the American Society of Breast Surgeons by Sattar, Abida K., Shahzad, Hania, Masroor, Taleaa, Martins, Russell Seth, Zahid, Nida, Amersi, Farin F.

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YAP–IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis by Taniguchi, Koji, Moroishi, Toshiro, de Jong, Petrus R., Krawczyk, Michal, Grebbin, Britta Moyo, Luo, Huiyan, Xu, Rui-hua, Golob-Schwarzl, Nicole, Schweiger, Caroline, Wang, Kepeng, Di Caro, Giuseppe, Feng, Ying, Fearon, Eric R., Raz, Eyal, Kenner, Lukas, Farin, Henner F., Guan, Kun-Liang, Haybaeck, Johannes, Datz, Christian, Zhang, Kang, Karin, Michael

“…Loss of tumor suppressor adenomatous polyposis coli (APC) activates β-catenin to initiate colorectal tumorigenesis. However, β-catenin (CTNNB1) activating…”
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A Prospective Study of Sentinel Node Biopsy Omission in Women Age ≥ 65 Years with ER+ Breast Cancer by Chung, Alice P., Dang, Catherine M., Karlan, Scott R., Amersi, Farin F., Phillips, Edward M., Boyle, Marissa K., Cui, Yujie, Giuliano, Armando E.

“…Background National guidelines recommend omitting SNB in older patients with favorable invasive breast cancer. However, there is a lack of prospective data…”
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TTC7A mutations disrupt intestinal epithelial apicobasal polarity by Bigorgne, Amélie E, Farin, Henner F, Lemoine, Roxane, Mahlaoui, Nizar, Lambert, Nathalie, Gil, Marine, Schulz, Ansgar, Philippet, Pierre, Schlesser, Patrick, Abrahamsen, Tore G, Oymar, Knut, Davies, E Graham, Ellingsen, Christian Lycke, Leteurtre, Emmanuelle, Moreau-Massart, Brigitte, Berrebi, Dominique, Bole-Feysot, Christine, Nischke, Patrick, Brousse, Nicole, Fischer, Alain, Clevers, Hans, de Saint Basile, Geneviève

“…Multiple intestinal atresia (MIA) is a rare cause of bowel obstruction that is sometimes associated with a combined immunodeficiency (CID), leading to…”
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Genetic Risk Factors for Major Bleeding in Patients Treated With Warfarin in a Community Setting by Roth, J A, Boudreau, D, Fujii, M M, Farin, F M, Rettie, A E, Thummel, K E, Veenstra, D L

“…The influence of warfarin pharmacogenomics on major bleeding risk has been little studied in long‐term users and non–specialist care settings. We conducted a…”
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Generation of L Cells in Mouse and Human Small Intestine Organoids by PETERSEN, Natalia, REIMANN, Frank, BARTFELD, Sina, FARIN, Henner F, RINGNALDA, Femke C, VRIES, Robert G. J, VAN DEN BRINK, Stieneke, CLEVERS, Hans, GRIBBLE, Fiona M, DE KONING, Eelco J. P

“…Upon a nutrient challenge, L cells produce glucagon-like peptide 1 (GLP-1), a powerful stimulant of insulin release. Strategies to augment endogenous GLP-1…”
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Changes in utilization of axillary dissection in women with invasive breast cancer and sentinel node metastasis after the ACOSOG Z0011 trial by Tseng, Joshua, Alban, Rodrigo F, Siegel, Emily, Chung, Alice, Giuliano, Armando E, Amersi, Farin F

“…The American College of Surgeons Oncology Group Z0011 (ACOSOG Z0011) trial demonstrated no survival advantage for women with clinical T1-T2 invasive breast…”
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ASO Visual Abstract: A Prospective Study of Sentinel Node Biopsy Omission in Women Age ≥ 65 with ER+ Breast Cancer by Chung, Alice P., Dang, Catherine M., Karlan, Scott R., Amersi, Farin F., Phillips, Edward M., Boyle, Marissa K., Cui, Yujie, Giuliano, Armando E.

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Impact of Postoperative Antibiotic Prophylaxis on Surgical Site Infections Rates After Mastectomy with Drains but Without Immediate Reconstruction: A Multicenter, Double-Blinded, Randomized Control Superiority Trial by Sattar, Abida K., Masroor, Taleaa, Martins, Russell Seth, Zahid, Nida, Shahzad, Hania, Soomro, Rufina, Saleem, Omema, Vohra, Lubna M., Zeeshan, Sana, Ashfaq, Muhammad Areeb, Khan, Irum, Nadeem, Rida, Fatima, Nikhat, Qureshi, Ayisha Afzal, Amersi, Farin F., Mahmood, Syed Faisal

“…Background There is no consensus on the use of postoperative antibiotic prophylaxis (PAP) after mastectomy with indwelling drains. We explored the utility of…”
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Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids by Wiechmann, Svenja, Maisonneuve, Pierre, Grebbin, Britta M., Hoffmeister, Meike, Kaulich, Manuel, Clevers, Hans, Rajalingam, Krishnaraj, Kurinov, Igor, Farin, Henner F., Sicheri, Frank, Ernst, Andreas

“…The small GTPases H, K, and NRAS are molecular switches indispensable for proper regulation of cellular proliferation and growth. Several mutations in the…”
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