Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia

Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that has been also associated to alterations in the lipid profile. This study aims to analyze hematological and biochemical parameters to provide knowled...

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Bibliographic Details
Published in:	Lipids in health and disease Vol. 16; no. 1; p. 74
Main Authors:	Aleluia, Milena Magalhães, da Guarda, Caroline Conceição, Santiago, Rayra Pereira, Fonseca, Teresa Cristina Cardoso, Neves, Fábia Idalina, de Souza, Regiana Quinto, Farias, Larissa Alves, Pimenta, Felipe Araújo, Fiuza, Luciana Magalhães, Pitanga, Thassila Nogueira, Ferreira, Júnia Raquel Dutra, Adorno, Elisângela Vitória, Cerqueira, Bruno Antônio Veloso, Gonçalves, Marilda de Souza
Format:	Journal Article
Language:	English
Published:	England BioMed Central 11-04-2017 BMC
Subjects:	alpha-Thalassemia - complications alpha-Thalassemia - genetics Anemia Anemia, Sickle Cell - blood Anemia, Sickle Cell - complications Anemia, Sickle Cell - genetics Anemia, Sickle Cell - physiopathology Automation Bilirubin Bilirubin - blood Biomarkers Biomarkers - blood Brazil Cardiovascular disease Cholesterol Cross-Sectional Studies Dehydrogenases Dyslipidemia Dyslipidemias - etiology Erythrocyte Count Erythrocyte Indices Erythrocytes Fetuses Gene Deletion Hematocrit Hematology Hemoglobin Hemoglobin H - genetics Hemolysis Heredity Heterozygote Homozygote Humans L-Lactate dehydrogenase L-Lactate Dehydrogenase - blood Laboratories Lactic acid Lipids Lipids - blood Lipoproteins Metabolic disorders Metabolites Mortality Nitric oxide Nitric Oxide - blood Occlusion Oxidative stress Platelet Count Sickle cell anemia Sickle cell disease Statistical analysis Studies Sub-phenotype Thalassemia Thrombosis Triglycerides α-thalassemia α-thalassemia Sub-phenotype Sickle cell anemia Dyslipidemia
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Summary:	Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that has been also associated to alterations in the lipid profile. This study aims to analyze hematological and biochemical parameters to provide knowledge about the SCA sub-phenotypes previously described and suggest a dyslipidemic sub-phenotype. A cross-sectional study was conducted from 2013 to 2014, and 99 SCA patients in steady state were enrolled. We assessed correlations and associations with hematological and biochemical data and investigated the co-inheritance of -α -thalassemia (-α -thal). Correlation analyses were performed using Spearman and Pearson coefficient. The median of quantitative variables between two groups was compared using t-test and Mann-Whitney. P-values <0.05 were considered statistically significant. We found significant association of high lactate dehydrogenase levels with decreased red blood cell count and hematocrit as well as high levels of total and indirect bilirubin. SCA patients with low nitric oxide metabolites had high total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol and reduced very low-density cholesterol, triglycerides, direct bilirubin level and reticulocyte counts. In SCA patients with high-density lipoprotein cholesterol greater than 40 mg/dL, we observed increased red blood cell count, hemoglobin, hematocrit, and fetal hemoglobin and decreased nitric oxide metabolites levels. The presence of -α -thal was associated with high red blood cell count and low mean corpuscular volume, mean corpuscular hemoglobin, platelet count and total and indirect bilirubin levels. Our results provide additional information about the association between biomarkers and co-inheritance of -α -thal in SCA, and suggest the role of dyslipidemia and nitric oxide metabolites in the characterization of this sub-phenotype.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1476-511X 1476-511X
DOI:	10.1186/s12944-017-0454-1