Search Results - "Farias, Caroline Brunetto"

Epidermal Growth Factor Receptor Regulation of Ewing Sarcoma Cell Function by Kersting, Nathália, Kunzler Souza, Bárbara, Araujo Vieira, Igor, Pereira Dos Santos, Rafael, Brufatto Olguins, Danielly, José Gregianin, Lauro, Tesainer Brunetto, André, Lunardi Brunetto, Algemir, Roesler, Rafael, Brunetto de Farias, Caroline, Schwartsmann, Gilberto

“…Ewing sarcoma (ES) is a type of childhood cancer probably arising from stem mesenchymal or neural crest cells. The epidermal growth factor receptor (EGFR) acts…”
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PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines by Izetti, Patricia, Hautefeuille, Agnes, Abujamra, Ana Lucia, de Farias, Caroline Brunetto, Giacomazzi, Juliana, Alemar, Bárbara, Lenz, Guido, Roesler, Rafael, Schwartsmann, Gilberto, Osvaldt, Alessandro Bersch, Hainaut, Pierre, Ashton-Prolla, Patricia

“…Summary TP53 mutation is a common event in many cancers, including pancreatic adenocarcinoma, where it occurs in 50–70 % of cases. In an effort to reactivate…”
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Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state by Rosset, Clévia, Jaeger, Mariane da Cunha, Filippi-Chiela, Eduardo, Reis, Larissa Brussa, Sartor, Ivaine Taís Sauthier, Oliveira Netto, Cristina Brinckmann, Farias, Caroline Brunetto de, Roesler, Rafael, Ashton-Prolla, Patricia

“…Tuberous sclerosis complex (TSC) is an autosomal dominant cancer predisposition disorder caused by heterozygous mutations in TSC1 or TSC2 genes and…”
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BDNF/TrkB signaling protects HT-29 human colon cancer cells from EGFR inhibition by de Farias, Caroline Brunetto, Heinen, Tiago Elias, dos Santos, Rafael Pereira, Abujamra, Ana Lucia, Schwartsmann, Gilberto, Roesler, Rafael

“…► BDNF protected HT-29 colorectal cancer cells from the antitumor effect of cetuximab. ► TrkB inhibition potentiated the antitumor effect of cetuximab. ►…”
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Oncogenic functions of ZEB1 in pediatric solid cancers: interplays with microRNAs and long noncoding RNAs by Fratini, Lívia, Jaeger, Mariane, de Farias, Caroline Brunetto, Brunetto, André T., Brunetto, Algemir L., Shaw, Lisa, Roesler, Rafael

“…The transcription factor Zinc finger E-box binding 1 (ZEB1) displays a range of regulatory activities in cell function and embryonic development, including…”
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Tropomyosin-Related Kinase Receptor and Neurotrophin Expression in Cutaneous Melanoma Is Associated with a Poor Prognosis and Decreased Survival by Antunes, Luís Carlos Moreira, Cartell, André, de Farias, Caroline Brunetto, Bakos, Renato Marchiori, Roesler, Rafael, Schwartsmann, Gilberto

“…Normally, activation of tropomyosin-related kinase (TRK) receptors by neurotrophins (NTs) stimulates intracellular pathways involved in cell survival and…”
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HDAC and MAPK/ERK Inhibitors Cooperate To Reduce Viability and Stemness in Medulloblastoma by da Cunha Jaeger, Mariane, Ghisleni, Eduarda Chiesa, Cardoso, Paula Schoproni, Siniglaglia, Marialva, Falcon, Tiago, Brunetto, André T., Brunetto, Algemir L., de Farias, Caroline Brunetto, Taylor, Michael D., Nör, Carolina, Ramaswamy, Vijay, Roesler, Rafael

“…Medulloblastoma (MB), which originates from embryonic neural stem cells (NSCs) or neural precursors in the developing cerebellum, is the most common malignant…”
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Uncovering the role of brain‐derived neurotrophic factor/tyrosine kinase receptor B signaling in head and neck malignancies by Moraes, Juliana Kern, Wagner, Vivian Petersen, Fonseca, Felipe Paiva, Vargas, Pablo Agustin, Farias, Caroline Brunetto, Roesler, Rafael, Martins, Manoela Domingues

“…Brain‐derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that was first known as responsible for sustain the growth,…”
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A logical model of Ewing sarcoma cell epithelial-to-mesenchymal transition supports the existence of hybrid cellular phenotypes by Silveira, Daner A, Gupta, Shantanu, da Cunha Jaeger, Mariane, Brunetto de Farias, Caroline, Mombach, José Carlos Merino, Sinigaglia, Marialva

“…Ewing sarcoma (ES) is a highly aggressive pediatric tumor driven by the RNA-binding protein EWS (EWS)/friend leukemia integration 1 transcription factor (FLI1)…”
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Stimulation of proliferation of U138-MG glioblastoma cells by gastrin-releasing peptide in combination with agents that enhance cAMP signaling by Farias, Caroline Brunetto, Lima, Rodrigo Cruz, Lima, Luciana Otero, Flores, Debora Gazzana, Meurer, Luise, Brunetto, Algemir Lunardi, Schwartsmann, Gilberto, Roesler, Rafael

“…Increasing evidence indicates that gastrin-releasing peptide (GRP) acts as an autocrine growth factor for brain tumors. However, it remains unclear whether the…”
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A New Brazilian Device for Cervical Cancer Screening: Acceptability and Accuracy of Self-sampling by Lichtenfels, Martina, Lorenzi, Noely Paula Cristina, Tacla, Maricy, Yokochi, Kaori, Frustockl, Flávia, Silva, Camila Alves, Silva, André Luiz da, Termini, Lara, Farias, Caroline Brunetto

“…To evaluate the accuracy and patient acceptability toward self-sampling using a new device - SelfCervix® - for detecting HPV-DNA.  A total of 73 women aged…”
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Expression and pharmacological inhibition of TrkB and EGFR in glioblastoma by Pinheiro, Kelly V., Thomaz, Amanda, Souza, Bárbara Kunzler, Metcalfe, Victoria Anne, Freire, Natália Hogetop, Brunetto, André Tesainer, de Farias, Caroline Brunetto, Jaeger, Mariane, Bambini, Victorio, Smith, Christopher G. S., Shaw, Lisa, Roesler, Rafael

“…A member of the Trk family of neurotrophin receptors, tropomyosin receptor kinase B (TrkB, encoded by the NTRK2 gene) is an increasingly important target in…”
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Gastrin-Releasing Peptide Receptor Knockdown Induces Senescence in Glioblastoma Cells by Menegotto, Pâmela Rossi, da Costa Lopez, Patrícia Luciana, Souza, Bárbara Kunzler, de Farias, Caroline Brunetto, Filippi-Chiela, Eduardo Cremonese, Vieira, Igor Araújo, Schwartsmann, Gilberto, Lenz, Guido, Roesler, Rafael

“…Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor, characterized by excessive cell proliferation, resistance to apoptosis, and…”
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EHMT2/G9a as an Epigenetic Target in Pediatric and Adult Brain Tumors by Souza, Barbara Kunzler, Freire, Natalia Hogetop, Jaeger, Mariane, de Farias, Caroline Brunetto, Brunetto, Algemir L, Brunetto, André T, Roesler, Rafael

“…Epigenetic mechanisms, including post-translational modifications of DNA and histones that influence chromatin structure, regulate gene expression during…”
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Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR by Laschuk Herlinger, Alice, Lovatto Michaelsen, Gustavo, Sinigaglia, Marialva, Fratini, Lívia, Nogueira Debom, Gabriela, Braganhol, Elizandra, Brunetto de Farias, Caroline, Lunardi Brunetto, Algemir, Tesainer Brunetto, André, da Cunha Jaeger, Mariane, Roesler, Rafael

“…Medulloblastoma (MB) is a heterogeneous group of malignant pediatric brain tumors, divided into molecular groups with distinct biological features and…”
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Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma by Souza, Barbara Kunzler, Freire, Natalia Hogetop, Monteiro, Thiago Santos, Herlinger, Alice Laschuk, Jaeger, Mariane, Dalmolin, Matheus G. S., de Farias, Caroline Brunetto, Gregianin, Lauro, Brunetto, André T., Brunetto, Algemir L., Thiele, Carol J., Roesler, Rafael

“…Changes in epigenetic programming have been proposed as being key events in the initiation and progression of childhood cancers. HMT euchromatic histone lysine…”
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Cancer Stem Cells and Chemoresistance in Ewing Sarcoma by Dos Santos, Rafael Pereira, Roesler, Rafael, Gregianin, Lauro, Brunetto, André T, da Cunha Jaeger, Mariane, Lunardi Brunetto, Algemir, de Farias, Caroline Brunetto

“…Resistance to chemotherapy poses a major challenge for cancer treatment. Reactivating a stem cell program resembling that seen in embryonic development can…”
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Stemness and Cell Cycle Regulators and Their Modulation by Retinoic Acid in Ewing Sarcoma by Battistella, Maria Eduarda, Freire, Natália Hogetop, Toson, Bruno, Dalmolin, Matheus, Fernandes, Marcelo A C, Tassinari, Isadora D, Jaeger, Mariane, Brunetto, André T, Brunetto, Algemir L, Gregianin, Lauro, de Farias, Caroline Brunetto, Roesler, Rafael

“…Retinoic acid (RA) regulates stemness and differentiation in human embryonic stem cells (ESCs). Ewing sarcoma (ES) is a pediatric tumor that may arise from the…”
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Molecular Basis of Distant Medulloblastoma Recurrence by Roesler, Rafael, Brunetto de Farias, Caroline, Isolan, Gustavo R

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Histone Deacetylase Inhibitors in Pediatric Brain Cancers: Biological Activities and Therapeutic Potential by Perla, Alexandre, Fratini, Lívia, Cardoso, Paula S., Nör, Carolina, Brunetto, André T., Brunetto, Algemir L., de Farias, Caroline Brunetto, Jaeger, Mariane, Roesler, Rafael

“…Brain cancers are the leading cause of cancer-related deaths in children. Biological changes in these tumors likely include epigenetic deregulation during…”
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