Search Results - "Faria, Rúben"

Development of Peptide-Based Nanoparticles for Mitochondrial Plasmid DNA Delivery by Faria, Rúben, Vivés, Eric, Boisguerin, Prisca, Sousa, Angela, Costa, Diana

“…A mitochondrion is a cellular organelle able to produce cellular energy in the form of adenosine triphosphate (ATP). As in the nucleus, mitochondria contain…”
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Delivery Systems for Mitochondrial Gene Therapy: A Review by Faria, Rúben, Boisguérin, Prisca, Sousa, Ângela, Costa, Diana

“…Mitochondria are membrane-bound cellular organelles of high relevance responsible for the chemical energy production used in most of the biochemical reactions…”
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Upgrading Mitochondria-Targeting Peptide-Based Nanocomplexes for Zebrafish In Vivo Compatibility Assays by Faria, Rúben, Vivès, Eric, Boisguérin, Prisca, Descamps, Simon, Sousa, Ângela, Costa, Diana

“…The lack of effective delivery systems has slowed the development of mitochondrial gene therapy. Delivery systems based on cell-penetrating peptides (CPPs)…”
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Optimization of peptide-plasmid DNA vectors formulation for gene delivery in cancer therapy exploring design of experiments by Sousa, Ângela, Almeida, Ana M., Faria, Rúben, Konate, Karidia, Boisguerin, Prisca, Queiroz, João A., Costa, Diana

“…[Display omitted] •The pDNA condensation ability of RALA and WRAP5 has been evaluated.•A design of experiments tool (DoE) was used to find the optimal…”
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Peptides vs. Polymers: Searching for the Most Efficient Delivery System for Mitochondrial Gene Therapy by Faria, Rúben, Paul, Milan, Biswas, Swati, Vivès, Eric, Boisguérin, Prisca, Sousa, Ângela, Costa, Diana

“…Together with the nucleus, the mitochondrion has its own genome. Mutations in mitochondrial DNA are responsible for a variety of disorders, including…”
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Development of Tailor-Made Dendrimer Ternary Complexes for Drug/Gene Co-Delivery in Cancer by Neves, Ana Raquel, Albuquerque, Tânia, Faria, Rúben, Paul, Milan, Biswas, Swati, Sousa, Ângela, Costa, Diana

“…Cancer gene therapy, mediated by non-viral systems, remains a major research focus. To contribute to this field, in this work we reported on the development of…”
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Polymer-peptide ternary systems as a tool to improve the properties of plasmid DNA vectors in gene delivery by Albuquerque, Tânia, Faria, Rúben, Sousa, Ângela, Neves, Ana R., Queiroz, João A., Costa, Diana

“…Polymer/peptide/plasmid DNA (pDNA) based ternary systems were developed by combining the great condensing ability of both polyethylenimine (PEI) and…”
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Physicochemical characterization and targeting performance of triphenylphosphonium nano-polyplexes by Faria, Rúben, Albuquerque, Tânia, Neves, Ana R., Bhatt, Himanshu, Biswas, Swati, Cardoso, Ana M., Pedroso de Lima, Maria C., Jurado, Amália S., Costa, Diana

“…Mitochondrial gene therapy can be seen as a promising tool and a revolutionary approach towards mitochondrial diseases arising from mitochondrial DNA…”
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Design of experiments to select triphenylphosphonium-polyplexes with suitable physicochemical properties for mitochondrial gene therapy by Sousa, Ângela, Faria, Rúben, Albuquerque, Tânia, Bhatt, Himanshu, Biswas, Swati, Queiroz, João A., Costa, Diana

“…Mitochondrial gene therapy can be seen as a promising tool and a revolutionary approach towards mitochondrial diseases arising from mitochondrial DNA…”
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Development of WRAP5 Peptide Complexes for Targeted Drug/Gene Co-Delivery toward Glioblastoma Therapy by Neves, Ana Raquel, Albuquerque, Tânia, Faria, Rúben, Gonçalves, Ana M, Santos, Cecília, Vivès, Eric, Boisguérin, Prisca, Passarinha, Luís A, Sousa, Ângela, Costa, Diana

“…Despite the great progress over the past few decades in both the diagnosis and treatment of a great variety of human cancers, glioblastoma remains the most…”
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Evidence That a Peptide-Drug/p53 Gene Complex Promotes Cognate Gene Expression and Inhibits the Viability of Glioblastoma Cells by Neves, Ana, Albuquerque, Tânia, Faria, Rúben, Santos, Cecília R A, Vivès, Eric, Boisguérin, Prisca, Carneiro, Diana, Bruno, Daniel F, Pavlaki, Maria D, Loureiro, Susana, Sousa, Ângela, Costa, Diana

“…Glioblastoma multiform (GBM) is considered the deadliest brain cancer. Conventional therapies are followed by poor patient survival outcomes, so novel and more…”
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Methotrexate-plasmid DNA polyplexes for cancer therapy: Characterization, cancer cell targeting ability and tuned in vitro transfection by Faria, Rúben, Sousa, Ângela, Neves, Ana R., Queiroz, João A., Costa, Diana

“…Cell targeting is still the most auspicious task in the design/development of innovative drug and gene delivery systems for advanced biomedical applications…”
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Measurement Properties of the Brazilian-Portuguese Version of the Lumbar Spine Instability Questionnaire by Araujo, Amanda Costa, da Cunha Menezes Costa, Lucíola, de Oliveira, Crystian Bittencourt Soares, Morelhão, Priscila Kalil, de Faria Negrão Filho, Rúben, Pinto, Rafael Zambelli, Costa, Leonardo Oliveira Pena

“…STUDY DESIGN.Cross-cultural adaptation and analysis of measurement properties. OBJECTIVE.To translate and cross-culturally adapt the Lumbar Spine Instability…”
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Influence of the exacerbation of patellofemoral pain on trunk kinematics and lower limb mechanics during stair negotiation by Briani, Ronaldo Valdir, Cannon, Jordan, Waiteman, Marina Cabral, Negrão Filho, Rúben de Faria, Magalhães, Fernando Henrique, de Azevedo, Fábio Mícolis

“…•Peak knee extensor moment is reduced after the exacerbation of PFP.•Peak ankle plantarflexor moment is increased after the exacerbation of PFP.•There are no…”
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Electromyographic analysis of the vertebral extensor muscles during the Biering-Sorensen Test by Santana, Ligia Moreira de, Nascimento, Paulo Roberto Carvalho do, Lima, Thais de Sousa, Lopes, Ana Carolina Tocilo, Araujo, Amanda Costa, Azevedo, Fábio Mícolis de, Negrão Filho, Rúben de Faria

“…The purpose of the study was to analyze the electromyographic signal of the multifidus, longissimus thoracis and the lumbar iliocostalis muscles during the…”
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Critical evaluation of physical activity questionnaires translated to Brazilian-Portuguese: a systematic review on cross-cultural adaptation and measurements properties by Silva, Fernanda Gonçalves, Oliveira, Crystian Bitencourt, Hisamatsu, Thalysi Mayumi, Negrão Filho, Ruben Faria, Rodrigues, Caio Russo Dutra, Franco, Marcia Rodrigues, Pinto, Rafael Zambelli

“…•Measurement properties of most physical activity questionnaires have not been fully tested.•Construct validation and reliability of most physical activity…”
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Conception of Plasmid DNA and Polyethylenimine Delivery Systems with Potential Application in DNA Vaccines Field by Costa, Diana, Sousa, Ângela, Faria, Rúben, Neves, Ana Raquel, Queiroz, João A

“…In DNA-based therapy research, the conception of a suitable vector to promote the target gene carriage, protection, and delivery to the cell is imperative…”
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Comparison of different analysis techniques for the determination of muscle onset in individuals with patellofemoral pain syndrome by Uliam Kuriki, Heloyse, Mícolis de Azevedo, Fábio, de Faria Negrão Filho, Rúben, Alves, Neri

“…Abstract To understand patellofemoral pain syndrome (PFPS), recent studies have focused on assessing the onset in the vastus medialis and vastus lateralis to…”
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Exploratory study of electromyographic behavior of the vastus medialis and vastus lateralis at neuromuscular fatigue onset by Silva, Cristiano Rocha da, Silva, Danilo de Oliveira, Ferrari, Deisi, Negrão Filho, Rúben de Faria, Alves, Neri, Azevedo, Fábio Mícolis de

“…This study aimed to determine and analyze the neuromuscular fatigue onset by median frequency (MDF) and the root mean square (RMS) behavior of an…”
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Relationship between therapeutic alliance and deep abdominal muscle recruitment in nonspecific low back pain sufferers by Nascimento, Paulo Roberto Carvalho do, Ferreira, Paulo Henrique, Azevedo, Fábio Mícolis de, Negrão Filho, Rúben de Faria

“…Chronic low back pain is a difficult condition to be treated. As some patients respond positively to treatment and others do not present any improvements, one…”
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