Senolytics prevent age-associated changes in female mice brain

[Display omitted] •Senolytic compounds as neuroprotectors.•Senolytic compounds reduce reactive species.•Senolytic compounds against neuroinflammation. Considering that the combination of dasatinib and quercetin (D + Q) demonstrated a neuroprotective action, as well as that females experience a decli...

Full description

Saved in:

Bibliographic Details
Published in:	Neuroscience letters Vol. 826; p. 137730
Main Authors:	Faria, Olivia Wyse, de Aguiar, Mayara Sandrielly Soares, de Mello, Julia Eisenhardt, Alvez, Fernando Lopez, Luduvico, Karina Pereira, Garcia, Driele Neske, Schneider, Augusto, Masternak, Michal M., Spanevello, Roselia Maria, Stefanello, Francieli Moro
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 15-03-2024
Subjects:	Acetylcholinesterase Acetylcholinesterase - metabolism Adenosine Triphosphatases Animals Antioxidants - pharmacology Brain Brain - metabolism Catalase - metabolism Dasatinib Female Mice Mice, Inbred C57BL Na+, K+-ATPase Oxidative Stress Quercetin Quercetin - pharmacology Rats Rats, Wistar Redox status Senotherapeutics Superoxide Dismutase - metabolism RS Dasatinib Brain Na+, K+-ATPase ACh GST SOD TBARS Acetylcholinesterase Senescence associated secretory phenotype SH Nitric oxide CAT Quercetin TNF-αTumor Redox status Nitric oxide synthase A-ChE Alzheimer’s disease D +Q Na(+), K(+)-ATPase
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	[Display omitted] •Senolytic compounds as neuroprotectors.•Senolytic compounds reduce reactive species.•Senolytic compounds against neuroinflammation. Considering that the combination of dasatinib and quercetin (D + Q) demonstrated a neuroprotective action, as well as that females experience a decline in hormonal levels during aging and this is linked to increased susceptibility to Alzheimer’s disease, in this study we evaluated the effect of D + Q on inflammatory and oxidative stress markers and on acetylcholinesterase and Na+, K+-ATPase activities in brain of female mice. Female C57BL/6 mice were divided in Control and D (5 mg/kg) + Q (50 mg/kg) treated. Treatment was administered via gavage for three consecutive days every two weeks starting at 30 days of age. The animals were euthanized at 6 months of age and at 14 months of age. Results indicate an increase in reactive species (RS), thiol content and lipid peroxidation followed by a reduction in nitrite levels and superoxide dismutase, catalase and glutathione S-transferase activity in the brain of control animals with age. D+Q protected against age-associated increase in RS and catalase activity reduction. Acetylcholinesterase activity was increased, while Na+, K+-ATPase activity was reduced at 14 months of age and D+Q prevented this reduction. These data demonstrate that D+Q can protect against age-associated neurochemical alterations in the female brain.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2024.137730