Impact of Transcranial Direct Current Stimulation in Pain, Fatigue, and Health Quality of Life of Patients with Idiopathic Inflammatory Myopathies: A Randomized, Double-Blind, Sham-Controlled Crossover Clinical Trial

Impact of Transcranial Direct Current Stimulation in Pain, Fatigue, and Health Quality of Life of Patients with Idiopathic Inflammatory Myopathies: A Randomized, Double-Blind, Sham-Controlled Crossover Clinical Trial

Objectives. To assess the effectiveness of transcranial direct current stimulation (tDCS) for pain, fatigue, physical function, and health-related quality of life in patients with idiopathic inflammatory myopathy (IIM). Methods. This randomized, double-blind, sham-controlled, crossover clinical tria...

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Published in:International journal of rheumatology Vol. 2024; pp. 1583506 - 9
Main Authors: Missé, Rafael Giovani, dos Santos, Alexandre Moura, Borges, Isabela Bruna Pires, Grecco, Marcus Vinicius, Faria, Marlise Sítima Mendes Simões, da Silva, Lorenza Rosa Silvério, Correia, Bruna Lindoso, Kim, Ana Woo Sook, Tanaka, Clarice, Greve, Júlia Maria D’Andrea, Baptista, Abrahão Fontes, Shinjo, Samuel Katsuyuki
Format: Journal Article
Language:English
Published: United States Hindawi 2024
Hindawi Limited
Subjects:
Aerobics
Anxiety
Cholesterol
Chronic illnesses
Clinical trials
Data collection
Electrodes
Exercise
Fatigue
Fibromyalgia
Fitness training programs
Intervention
Medical personnel
Metabolic disorders
Pain
Physical fitness
Professionals
Quality of life
Questionnaires
Rheumatic diseases
Rheumatology
Sleep
Statistical analysis
Brazil
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Summary:Objectives. To assess the effectiveness of transcranial direct current stimulation (tDCS) for pain, fatigue, physical function, and health-related quality of life in patients with idiopathic inflammatory myopathy (IIM). Methods. This randomized, double-blind, sham-controlled, crossover clinical trial enrolled IIM patients with fatigue and pain who received tDCS (20 min, 2 mA) or sham stimulation for 10 daily sessions. Electrodes were placed according to the 10/20 EEG system. Both the groups underwent aerobic exercise training during the intervention period. The patients were evaluated for disease perception, pain, and fatigue using uni-multidimensional questionnaires and physical tests in the periods before and after the first and second interventions and after 12 weeks of follow-up. Results. After the tDCS intervention, a reduction in the general score of multidimensional pain of 32.0 (1.5-38.0) vs. 0.0 (0.0-13.4) with effect size (ES) of -0.78 was noted, and after sham intervention, a reduction of 26.0 (0.0-37.0) vs. 5.0 (0.0-19.2) with ES of -0.54 (P=0.047) was also noted. Similar results were evidenced with fatigue (22.5 (15.4-33.2) vs. 5.5 (0.0-14.6) with ES of -0.82) and sham intervention (21.0 (15.8-29.5) vs. 4.0 (4.0-17.5) with ES of -0.80 (P=0.012)). There were no differences in the domains of the fatigue and pain questionnaires. Adherence was observed in 88.8% of the patients without adverse events. Conclusion. The association of tDCS with aerobic training promoted additional effects in relation to the group subjected to placebo stimulation on general pain and fatigue scores, as well as on pain intensity, without changes in the subdomains of the pain and fatigue questionnaire. This trial is registered with NCT04678635.
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Academic Editor: Alicia Rodriguez-Pla
ISSN:1687-9260
1687-9279
DOI:10.1155/2024/1583506