Differential expression of Cadherins switch and Caveolin-2 during stages of oral carcinogenesis

Background: Oral squamous cell carcinoma (OSCC) accounts for 90% of oral malignancies, which may be preceded by oral potentially malignant disorders (OPMDs). Cancer progression involves the downregulation of epithelial markers (E-cadherin) and the upregulation of mesenchymal markers (N-cadherin), wh...

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Published in:	Journal of oral and maxillofacial pathology : JOMFP Vol. 27; no. 3; pp. 507 - 514
Main Authors:	Nascimento, Rebeca B., Machado, Isadora A. R., Silva, Jamerson C., Faria, Lorena A. S., Borba, Fernanda C., Porto, Lia P. A., Santos, Jean N., Ramalho, Luciana M. P., Rodini, Camila O., Rodrigues, Maria Fernanda S. D., Paiva, Katiúcia B. S., Xavier, Flávia C. A.
Format:	Journal Article
Language:	English
Published:	India Wolters Kluwer - Medknow 01-07-2023
Subjects:	Original
Online Access:	Get full text
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Summary:	Background: Oral squamous cell carcinoma (OSCC) accounts for 90% of oral malignancies, which may be preceded by oral potentially malignant disorders (OPMDs). Cancer progression involves the downregulation of epithelial markers (E-cadherin) and the upregulation of mesenchymal markers (N-cadherin), which together characterise the epithelial–mesenchymal transition (EMT). Furthermore, caveolin can act on cell adhesion and migration events that regulate the expression of the E-cadherin/α-β-catenin complex, thus favouring aggressive biological behaviour. This study aimed to analyse the immunoexpression of E-cadherin, N-cadherin and caveolin-2 at different stages of oral carcinogenesis to identify reliable biomarkers to predict malignant potential. Methods: Expressions of E-cadherin and N-cadherin in 14 normal oral mucosae (NOM), 14 OPMD and 33 OSCC specimens were evaluated using immunohistochemistry. Clinicopathological parameters were also assessed. Results: E-cadherin immunoexpression was significantly reduced during the progression of oral carcinogenesis ( P = 0.0018). N-cadherin immunoexpression did not show any statistical differences between these groups. However, a representative number of N-cadherin-positive OSCC cases did not express E-cadherin. The expression of caveolin-2 increased significantly with the progression of the disease, from NOM to OSCC ( P value: 0.0028). Conclusion: These findings indicate that cadherin switch and caveolin-2 immunoexpression may be regulatory events in oral carcinogenesis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0973-029X 1998-393X
DOI:	10.4103/jomfp.jomfp_28_23