Pathogenomics analysis of Leishmania spp.: flagellar gene families of putative virulence factors

The trypanosomatid flagellar apparatus contains conventional and unique features, whose roles in infectivity are still enigmatic. Although the flagellum and the flagellar pocket are critical organelles responsible for all vesicular trafficking between the cytoplasm and cell surface, still very littl...

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Bibliographic Details
Published in:	Omics (Larchmont, N.Y.) Vol. 9; no. 2; p. 173
Main Authors:	Oliveira, Diana M, Gouveia, Joao Jose S, Diniz, Nilo B, Pacheco, Ana Carolina L, Vasconcelos, Elton Jose R, Diniz, Michely C, Viana, Daniel A, Ferreira, Thiago D, Albuquerque, Marianna C, Fortier, Daniel C, Maia, Allan R S, Costa, Luis A C, Melo, João Osmar P, da Silva, Maria Cristina, Walter, Cezar A, Faria, Jose O, Tome, Adriana R, Gomes, Marcos Jose N, Oliveira, Sonia M P, Araújo-Filho, Raimundo, Costa, Raimundo B, Maggioni, Rodrigo
Format:	Journal Article
Language:	English
Published:	United States 2005
Subjects:	Amino Acid Sequence Animals Databases, Genetic Flagella - genetics Flagella - physiology Genes, Protozoan Genome, Protozoan Leishmania - classification Leishmania - genetics Leishmania - pathogenicity Leishmania - physiology Molecular Sequence Data Multigene Family Proteome Protozoan Proteins - genetics Sequence Homology, Amino Acid Virulence - genetics
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Summary:	The trypanosomatid flagellar apparatus contains conventional and unique features, whose roles in infectivity are still enigmatic. Although the flagellum and the flagellar pocket are critical organelles responsible for all vesicular trafficking between the cytoplasm and cell surface, still very little is known about their roles in pathogenesis and how molecules get to and from the flagellar pocket. The ongoing analysis of the genome sequences and proteome profiles of Leishmania major and L infantum, Trypanosoma cruzi, T. brucei, and T. gambiensi ( www.genedb.org ), coupled with our own work on L. chagasi (as part of the Brazilian Northeast Genome Program- www.progene.ufpe.br ), prompted us to scrutinize flagellar genes and proteins of Leishmania spp. promastigotes that could be virulence factors in leishmaniasis. We have identified some overlooked parasite factors such as the MNUDC-1 (a protein involved in nuclear development and genomic fusion) and SQS (an enzyme of sterol biosynthesis), among the described flagellar gene families. A database concerning the results of this work, as well as of other studies of Leishmania and its organelles, is available at http://nugen.lcc.uece.br/LPGate . It will serve as a convenient bioinformatics resource on genomics and pathology of the etiological agents of leishmaniasis.
ISSN:	1536-2310
DOI:	10.1089/omi.2005.9.173