Search Results - "Farhadi, Shaheen A"

Intra-articular delivery of an indoleamine 2,3-dioxygenase galectin-3 fusion protein for osteoarthritis treatment in male Lewis rats by Partain, Brittany D, Bracho-Sanchez, Evelyn, Farhadi, Shaheen A, Yarmola, Elena G, Keselowsky, Benjamin G, Hudalla, Gregory A, Allen, Kyle D

“…Osteoarthritis (OA) is driven by low-grade inflammation, and controlling local inflammation may offer symptomatic relief. Here, we developed an indoleamine…”
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Locally anchoring enzymes to tissues via extracellular glycan recognition by Farhadi, Shaheen A., Bracho-Sanchez, Evelyn, Fettis, Margaret M., Seroski, Dillon T., Freeman, Sabrina L., Restuccia, Antonietta, Keselowsky, Benjamin G., Hudalla, Gregory A.

“…Success of enzymes as drugs requires that they persist within target tissues over therapeutically effective time frames. Here we report a general strategy to…”
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Hierarchical self-assembly and emergent function of densely glycosylated peptide nanofibers by Restuccia, Antonietta, Seroski, Dillon T., Kelley, Karen L., O’Bryan, Christopher S., Kurian, Justin J., Knox, Kevin R., Farhadi, Shaheen A., Angelini, Thomas E., Hudalla, Gregory A.

“…Glycosylation alters protein form and function by establishing intermolecular forces that mediate specific interactions while preventing non-specific…”
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A Synthetic Tetramer of Galectin-1 and Galectin-3 Amplifies Pro-apoptotic Signaling by Integrating the Activity of Both Galectins by Farhadi, Shaheen A, Fettis, Margaret M, Liu, Renjie, Hudalla, Gregory A

“…Galectin-1 (G1) and galectin-3 (G3) are carbohydrate-binding proteins that can signal apoptosis in T cells. We recently reported that a synthetic tetramer with…”
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Physical tuning of galectin-3 signaling by Farhadi, Shaheen A., Liu, Renjie, Becker, Matthew W., Phelps, Edward A., Hudalla, Gregory A.

“…Galectin-3 (Gal3) exhibits dynamic oligomerization and promiscuous binding, which can lead to concomitant activation of synergistic, antagonistic, or…”
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Enzymes as Immunotherapeutics by Farhadi, Shaheen A, Bracho-Sanchez, Evelyn, Freeman, Sabrina L, Keselowsky, Benjamin G, Hudalla, Gregory A

“…Enzymes are attractive as immunotherapeutics because they can catalyze shifts in the local availability of immunostimulatory and immunosuppressive signals…”
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Engineering galectin–glycan interactions for immunotherapy and immunomodulation by Farhadi, Shaheen A, Hudalla, Gregory A

“…Galectins, a 15-member family of soluble carbohydrate-binding proteins, are receiving increasing interest as therapeutic targets for immunotherapy and…”
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Experimental and Computational Models of Transport of Galectin-3 Through Glycosylated Matrix by Piñeiro-Llanes, Janny, Rodriguez, Camille D., Farhadi, Shaheen A., Hudalla, Gregory A., Sarntinoranont, Malisa, Simmons, Chelsey S.

“…Altered extracellular matrix (ECM) production is a hallmark of many fibroproliferative diseases, including certain cancers. The high incidence of glycan-rich…”
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A chimeric, multivalent assembly of galectin-1 and galectin-3 with enhanced extracellular activity by Fettis, Margaret M, Farhadi, Shaheen A, Hudalla, Gregory A

“…Galectins are attractive therapeutic candidates to control aberrant immune system activation because they can alter the phenotype and function of various…”
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Site-Specific Cross-Linking of Galectin-1 Homodimers via Poly(ethylene glycol) Bismaleimide by Kane, Bryant J., Fettis, Margaret M., Farhadi, Shaheen A., Liu, Renjie, Hudalla, Gregory A.

“…Introduction The promise of the natural immunoregulator, Galectin-1 (Gal1), as an immunomodulatory therapeutic is challenged by its unstable homodimeric…”
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Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase by Bracho-Sanchez, Evelyn, Rocha, Fernanda G., Bedingfield, Sean K., Partain, Brittany D., Macias, Sabrina L., Brusko, Maigan A., Colazo, Juan M., Fettis, Margaret M., Farhadi, Shaheen A., Helm, Eric Y., Koenders, Kevin, Kwiatkowski, Alexander J., Restuccia, Antonietta, Morales, Bethsymarie Soto, Wanchoo, Arun, Avram, Dorina, Allen, Kyle D., Duvall, Craig L., Wallet, Shannon M., Hudalla, Gregory A., Keselowsky, Benjamin G.

“…The treatment of chronic inflammation with systemically administered anti-inflammatory treatments is associated with moderate-to-severe side effects, and the…”
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Evaluation of Self-Assembled Glycopeptide Nanofibers Modified with N,N′‑Diacetyllactosamine for Selective Galectin‑3 Recognition and Inhibition by Restuccia, Antonietta, Fettis, Margaret M., Farhadi, Shaheen A., Molinaro, Matthew D., Kane, Bryant, Hudalla, Gregory A.

“…The carbohydrate-binding protein galectin-3 (Gal3) is an attractive drug target due to its role as a modulator of cell behavior in various pathological…”
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