Search Results - "Farfel, Jose M."

Sexual dimorphism in the human olfactory bulb: females have more neurons and glial cells than males by Oliveira-Pinto, Ana V, Santos, Raquel M, Coutinho, Renan A, Oliveira, Lays M, Santos, Gláucia B, Alho, Ana T L, Leite, Renata E P, Farfel, José M, Suemoto, Claudia K, Grinberg, Lea T, Pasqualucci, Carlos A, Jacob-Filho, Wilson, Lent, Roberto

“…Sex differences in the human olfactory function reportedly exist for olfactory sensitivity, odorant identification and memory, and tasks in which odors are…”
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Relation of genomic variants for Alzheimer disease dementia to common neuropathologies by Farfel, Jose M, Yu, Lei, Buchman, Aron S, Schneider, Julie A, De Jager, Philip L, Bennett, David A

“…OBJECTIVE:To investigate the associations of previously reported Alzheimer disease (AD) dementia genomic variants with common neuropathologies. METHODS:This is…”
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Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities by Katsumata, Yuriko, Shade, Lincoln M., Hohman, Timothy J., Schneider, Julie A., Bennett, David A., Farfel, Jose M., Kukull, Walter A., Fardo, David W., Nelson, Peter T.

“…The classic pathologic hallmarks of Alzheimer's disease (AD) are amyloid plaques and neurofibrillary tangles (AD neuropathologic changes, or ADNC). However,…”
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Evaluating genomic signatures of aging in brain tissue as it relates to Alzheimer’s disease by Lynch, Megan T., Taub, Margaret A., Farfel, Jose M., Yang, Jingyun, Abadir, Peter, De Jager, Philip L., Grodstein, Francine, Bennett, David A., Mathias, Rasika A.

“…Telomere length (TL) attrition, epigenetic age acceleration, and mitochondrial DNA copy number (mtDNAcn) decline are established hallmarks of aging. Each has…”
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Dementia and autopsy-verified causes of death in racially-diverse older Brazilians by Farfel, Jose M, Leurgans, Sue E, Capuano, Ana W, de Moraes Sampaio, Maria Carolina, Wilson, Robert S, Schneider, Julie A, Bennett, David A

“…While dementia has been associated with specific causes of death, previous studies were relatively small autopsy series or population-based studies lacking…”
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Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease by Silva, Aderbal R T, Santos, Ana Cecília Feio, Farfel, Jose M, Grinberg, Lea T, Ferretti, Renata E L, Campos, Antonio Hugo Jose Froes Marques, Cunha, Isabela Werneck, Begnami, Maria Dirlei, Rocha, Rafael M, Carraro, Dirce M, de Bragança Pereira, Carlos Alberto, Jacob-Filho, Wilson, Brentani, Helena

“…Alzheimer's disease (AD) is characterized by progressive cognitive decline associated with a featured neuropathology (neuritic plaques and neurofibrillary…”
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Brain autopsies of critically ill COVID-19 patients demonstrate heterogeneous profile of acute vascular injury, inflammation and age-linked chronic brain diseases by Agrawal, Sonal, Farfel, Jose M, Arfanakis, Konstantinos, Al-Harthi, Lena, Shull, Tanner, Teppen, Tara L, Evia, Arnold M, Patel, Mayur B, Ely, E Wesley, Leurgans, Sue E, Bennett, David A, Mehta, Rupal, Schneider, Julie A

“…This study examined neuropathological findings of patients who died following hospitalization in an intensive care unit with SARS-CoV-2. Data originate from 20…”
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Alzheimer's disease frequency peaks in the tenth decade and is lower afterwards by Farfel, Jose M, Yu, Lei, Boyle, Patricia A, Leurgans, Sue, Shah, Raj C, Schneider, Julie A, Bennett, David A

“…Age is the most robust risk factor for Alzheimer's dementia, however there is little data on the relation of age to Alzheimer's disease (AD) and other common…”
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Morphometric measurements of systemic atherosclerosis and visceral fat: Evidence from an autopsy study by Nishizawa, Aline, Suemoto, Claudia K, Farias-Itao, Daniela S, Campos, Fernanda M, Silva, Karen C S, Bittencourt, Marcio S, Grinberg, Lea T, Leite, Renata E P, Ferretti-Rebustini, Renata E L, Farfel, Jose M, Jacob-Filho, Wilson, Pasqualucci, Carlos A

“…Morphometric measurements of systemic atherosclerosis and direct quantification of visceral fat are only possible using materials from autopsy studies…”
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Transcriptional alterations related to neuropathology and clinical manifestation of Alzheimer's disease by Silva, Aderbal R T, Grinberg, Lea T, Farfel, Jose M, Diniz, Breno S, Lima, Leandro A, Silva, Paulo J S, Ferretti, Renata E L, Rocha, Rafael M, Filho, Wilson Jacob, Carraro, Dirce M, Brentani, Helena

“…Alzheimer's disease (AD) is the most common cause of dementia in the human population, characterized by a spectrum of neuropathological abnormalities that…”
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Neuropsychiatric symptoms in Brazilians with mild cognitive impairment and dementia by Wilson, Robert S., Capuano, Ana W, Sampaio, Carolina, Leurgans, Sue E., Barnes, Lisa L., Farfel, Jose M., Bennett, David A.

“…Introduction Knowledge is limited about behavioral and psychological symptoms of mild cognitive impairment (MCI) and dementia in racial and ethnic minorities…”
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Association of APOE with tau-tangle pathology with and without β-amyloid by Farfel, Jose M, Yu, Lei, De Jager, Philip L, Schneider, Julie A, Bennett, David A

“…Abstract This study tested the hypothesis that the association of apolipoprotein E ( APOE ) with paired helical filament tau (PHF-tau) tangle pathology differs…”
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Person-Specific Contributions of Brain Pathologies to Progressive Parkinsonism in Older Adults by Buchman, Aron S, Yu, Lei, Oveisgharan, Shahram, Farfel, Jose M, Schneider, Julie A, Bennett, David A

“…Abstract Background Mixed-brain pathologies are the most common cause of progressive parkinsonism in older adults. We tested the hypothesis that the impact of…”
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Association of Alzheimer’s Disease and Other Neuropathologies With Functional Disability in Persons With and Without Dementia by Farfel, Jose M, Capuano, Ana W, Buchman, Aron S, Schneider, Julie A, Bennett, David A

“…Abstract Background Dementia results from multiple neuropathologies causing cognitive impairment sufficiently severe to affect functional status. However,…”
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Acculturation in Context: The Relationship Between Acculturation and Socioenvironmental Factors With Level of and Change in Cognition in Older Latinos by Lamar, Melissa, Barnes, Lisa L, Leurgans, Sue E, Fleischman, Debra A, Farfel, Jose M, Bennett, David A, Marquez, David X

“…Abstract Objectives Latinos are 1.5 times as likely to develop Alzheimer’s dementia as non-Latino Whites. This health disparity may arise from multiple…”
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APOE and cerebral amyloid angiopathy in community-dwelling older persons by Yu, Lei, Boyle, Patricia A, Nag, Sukriti, Leurgans, Sue, Buchman, Aron S, Wilson, Robert S, Arvanitakis, Zoe, Farfel, Jose M, De Jager, Philip L, Bennett, David A, Schneider, Julie A

“…Abstract Both cerebral amyloid angiopathy and Alzheimer's disease pathology involve abnormal β-amyloid processing. We aim to elucidate the relationship of the…”
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Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study by Suemoto, Claudia K, Ferretti-Rebustini, Renata E L, Rodriguez, Roberta D, Leite, Renata E P, Soterio, Luciana, Brucki, Sonia M D, Spera, Raphael R, Cippiciani, Tarcila M, Farfel, Jose M, Chiavegatto Filho, Alexandre, Naslavsky, Michel Satya, Zatz, Mayana, Pasqualucci, Carlos A, Jacob-Filho, Wilson, Nitrini, Ricardo, Grinberg, Lea T

“…Clinicopathological studies are important in determining the brain lesions underlying dementia. Although almost 60% of individuals with dementia live in…”
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Neuroticism, negative life events, and dementia in older White and Black Brazilians by Capuano, Ana W., Wilson, Robert S., Leurgans, Sue E., Sampaio, Carolina, Barnes, Lisa L., Farfel, Jose M., Bennett, David A.

“…Objective Exposure to negative life events (NLEs) and neuroticism are associated with dementia. It is unknown whether neuroticism explains or modifies the…”
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Mercury and selenium distribution in human brain tissue using synchrotron micro-X-ray fluorescence by Webb, Alexis N, Antipova, Olga, Shughoury, Serena, Farfel, Jose M, Bennett, David A, Du, Yansheng, Zheng, Wei, Nie, Linda H

“…Abstract Mercury is a well-recognized environmental contaminant and neurotoxin, having been associated with a number of deleterious neurological conditions…”
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Relationship of Purpose in Life to Dementia in Older Black and White Brazilians by Wilson, Robert S, Capuano, Ana W, Sampaio, Carolina, Leurgans, Sue E, Barnes, Lisa L, Boyle, Patricia A, Farfel, Jose M, Bennett, David A

“…To test the hypothesis that higher level of purpose in life is associated with lower likelihood of dementia and mild cognitive impairment (MCI) in older…”
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