Search Results - "Fares, Raafat"

Standardized environmental enrichment supports enhanced brain plasticity in healthy rats and prevents cognitive impairment in epileptic rats by Fares, Raafat P, Belmeguenai, Amor, Sanchez, Pascal E, Kouchi, Hayet Y, Bodennec, Jacques, Morales, Anne, Georges, Béatrice, Bonnet, Chantal, Bouvard, Sandrine, Sloviter, Robert S, Bezin, Laurent

“…Environmental enrichment of laboratory animals influences brain plasticity, stimulates neurogenesis, increases neurotrophic factor expression, and protects…”
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Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons by Sanchez, Pascal E, Fares, Raafat P, Risso, Jean-Jacques, Bonnet, Chantal, Bouvard, Sandrine, Le-Cavorsin, Marion, Georges, Béatrice, Moulin, Colette, Belmeguenai, Amor, Bodennec, Jacques, Morales, Anne, Pequignot, Jean-Marc, Baulieu, Etienne-Emile, Levine, Robert A, Bezin, Laurent

“…Erythropoietin receptor (EpoR) binding mediates neuroprotection by endogenous Epo or by exogenous recombinant human (rh)Epo. The level of EpoR gene expression…”
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Erythropoietin receptor expression is concordant with erythropoietin but not with common β chain expression in the rat brain throughout the life span by Sanchez, Pascal E., Navarro, Fabrice P., Fares, Raafat P., Nadam, Jérémie, Georges, Béatrice, Moulin, Colette, Le Cavorsin, Marion, Bonnet, Chantal, Ryvlin, Philippe, Belmeguenai, Amor, Bodennec, Jacques, Morales, Anne, Bezin, Laurent

“…Brain effects of erythropoietin (Epo) are proposed to involve a heteromeric receptor comprising the classical Epo receptor (Epo‐R) and the common β chain (βc)…”
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Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats by Navarro, Fabrice P, Fares, Raafat P, Sanchez, Pascal E, Nadam, Jérémie, Georges, Béatrice, Moulin, Colette, Morales, Anne, Pequignot, Jean-Marc, Bezin, Laurent

“…Heparanase is an endo-β- d-glucuronidase which specifically cleaves extracellular and cell surface heparan sulphates at intra-chain sites. Its enzymatic…”
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Simultaneous assessment of central nervous and respiratory systems using jacketed telemetry in socially-housed rats: Application of the “3Rs” principles in core battery safety pharmacology studies by Fares, Raafat, Champéroux, Pascal

“…Central nervous (CNS) and respiratory systems are routinely investigated in safety pharmacology core battery studies. For small molecules, the assessment of…”
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In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry by Champeroux, Pascal, Thireau, Jérôme, Le Guennec, Jean-Yves, Fares, Raafat

“…The principle of proportionality of the systolic area of the central aortic pressure to stroke volume (SV) has been long known. The aim of the present work was…”
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Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system by Fares, Raafat, Flénet, Timothé, Vial, Jonathan, Ravaz, Marine, Roger, Virginie, Bory, Christophe, Baudet, Stéphane

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Implementation of DSI FinePointe® whole body plethysmography method in freely moving rats by Fares, Raafat, Bory, Christophe, Valgalier, Christophe, Baudet, Stephane

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Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs by Champéroux, Pascal, Fares, Raafat, Bastogne, Thierry, Richard, Serge, Le Guennec, Jean‐Yves, Thireau, Jérôme

“…Background and Purpose HERG blocking drugs known for their propensity to trigger Torsades de Pointes (TdP) were reported to induce a sympatho‐vagal…”
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Combined in silico model of cardiac electrophysiological activity and modulation by the autonomic nervous system by Le Guennec, Jean-Yves, Champéroux, Pascal, Gavotto, Arthur, Cambonie, Gilles, Goual, Lamia, Bounasri, Elisa, Lacampagne, Alain, Farès, Raafat, Thireau, Jerome

“…the autonomic nervous system (ANS) is both a recognized trigger and modulator of arrhythmogenesis [1]. Thanks to a new method of electrocardiogram analysis, we…”
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Erythropoietin receptor expression is concordant with erythropoietin but not with common beta chain expression in the rat brain throughout lifespan by Sanchez, Pascal E, Navarro, Fabrice P, Fares, Raafat P, Nadam, Jeremie, Georges, Beatrice, Moulin, Colette, Le Cavorsin, Marion, Bonnet, Chantal, Ryvlin, Philippe, Belmeguenai, Amor, Bodennec, Jacques, Morales, Anne, Bezin, Laurent

“…Brain effects of erythropoietin (Epo) are proposed to involve a heteromeric receptor comprising the classical Epo receptor (Epo-R) and the common chain (c)…”
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