Search Results - "Fareh, Mohamed"

TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments by Fareh, Mohamed, Yeom, Kyu-Hyeon, Haagsma, Anna C., Chauhan, Sweeny, Heo, Inha, Joo, Chirlmin

“…The RNA-binding protein TRBP is a central component of the Dicer complex. Despite a decade of biochemical and structural studies, the essential functionality…”
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TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms by Kim, Boseon, Ha, Minju, Loeff, Luuk, Chang, Hyeshik, Simanshu, Dhirendra K, Li, Sisi, Fareh, Mohamed, Patel, Dinshaw J, Joo, Chirlmin, Kim, V Narry

“…Terminal uridylyl transferases (TUTs) function as integral regulators of microRNA (miRNA) biogenesis. Using biochemistry, single‐molecule, and deep sequencing…”
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Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance by Fareh, Mohamed, Zhao, Wei, Hu, Wenxin, Casan, Joshua M. L., Kumar, Amit, Symons, Jori, Zerbato, Jennifer M., Fong, Danielle, Voskoboinik, Ilia, Ekert, Paul G., Rudraraju, Rajeev, Purcell, Damian F. J., Lewin, Sharon R., Trapani, Joseph A.

“…The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously…”
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Subversion of autophagy in adherent invasive Escherichia coli-infected neutrophils induces inflammation and cell death by Chargui, Abderrahman, Cesaro, Annabelle, Mimouna, Sanda, Fareh, Mohamed, Brest, Patrick, Naquet, Philippe, Darfeuille-Michaud, Arlette, Hébuterne, Xavier, Mograbi, Baharia, Vouret-Craviari, Valérie, Hofman, Paul

“…Invading bacteria are recognized, captured and killed by a specialized form of autophagy, called xenophagy. Recently, defects in xenophagy in Crohn's disease…”
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Hydatid cyst of the uterus: Very rare location by Bouknani, Nawal, Kassimi, Mariam, Saibari, Rayhana Charif, Fareh, Mohamed, Mahi, Mohamed, Rami, Amal

“…The involvement of the genital tract of a hydatid cyst is rare and the occurrence in the uterus is an extreme rarity. The diagnosis of this localization is…”
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Manganese is highly effective in protecting cells from cadmium intoxication by Martin, Patrick, Fareh, Mohamed, Poggi, Marie Christine, Boulukos, Kim E., Pognonec, Philippe

“…Cadmium poisoning results in cell death. Although several intracellular pathways have been identified in this response, transport systems responsible for…”
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Abstract 1094: Utilizing CRISPR-Cas13 as a novel functional genomics tool to characterize PAX3-FOXO1 in alveolar rhabdomyosarcoma by Zhao, Andrea, Brown, Lauren M., Fareh, Mohamed, Ekert, Paul G.

“…Abstract Background: CRISPR-Cas13 (Cas13) is an RNA editing system that can knockdown gene transcripts with higher efficiency and specificity than RNA…”
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Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition by Hogg, Simon J., Motorna, Olga, Cluse, Leonie A., Johanson, Timothy M., Coughlan, Hannah D., Raviram, Ramya, Myers, Robert M., Costacurta, Matteo, Todorovski, Izabela, Pijpers, Lizzy, Bjelosevic, Stefan, Williams, Tobias, Huskins, Shannon N., Kearney, Conor J., Devlin, Jennifer R., Fan, Zheng, Jabbari, Jafar S., Martin, Ben P., Fareh, Mohamed, Kelly, Madison J., Dupéré-Richer, Daphné, Sandow, Jarrod J., Feran, Breon, Knight, Deborah, Khong, Tiffany, Spencer, Andrew, Harrison, Simon J., Gregory, Gareth, Wickramasinghe, Vihandha O., Webb, Andrew I., Taberlay, Phillippa C., Bromberg, Kenneth D., Lai, Albert, Papenfuss, Anthony T., Smyth, Gordon K., Allan, Rhys S., Licht, Jonathan D., Landau, Dan A., Abdel-Wahab, Omar, Shortt, Jake, Vervoort, Stephin J., Johnstone, Ricky W.

“…To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigenomic and transcriptomic…”
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SAT-377 CRISPR-Cas13b-mediated suppression of hepatitis B surface antigen-pre-clinical investigations of a new therapeutic approach by McCoullough, Laura, Fareh, Mohamed, Hu, Wenxin, Sozzi, Vitina, Makhlouf, Christina, Droungas, Yianni, Lee, Chee Leng, Netter, Hans, Takawy, Mina, Lewin, Sharon, Purcell, Damian, Holmes, Jacinta, Trapani, Joseph, Littlejohn, Margaret, Revill, Peter

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Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth by Fareh, Mohamed, Almairac, Fabien, Turchi, Laurent, Burel-Vandenbos, Fanny, Paquis, Philippe, Fontaine, Denys, Lacas-Gervais, Sandra, Junier, Marie-Pierre, Chneiweiss, Hervé, Virolle, Thierry

“…Glioblastomas are incurable primary brain tumors that affect patients of all ages. The aggressiveness of this cancer has been attributed in part to the…”
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Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing by Hu, Wenxin, Kumar, Amit, Ahmed, Syed Faraz, Qi, Shijiao, Ma, David K. G., Chen, Honglin, Singh, Gurjeet J., Casan, Joshua M. L., Haber, Michelle, Voskoboinik, Ilia, McKay, Matthew R., Trapani, Joseph A., Ekert, Paul G., Fareh, Mohamed

“…The development of precise RNA-editing tools is essential for the advancement of RNA therapeutics. CRISPR (clustered regularly interspaced short palindromic…”
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An agent-based approach for resource allocation in the cloud computing environment by Fareh, Mohamed El-kabir, Kazar, Okba, Femmam, Manel, Bourekkache, Samir

“…One of the major challenges in cloud computing is Resources' allocation. In such environment, the providers and the users have different objectives; providers…”
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CRISPR-Cas13b-mediated suppression of HBV replication and protein expression by McCoullough, Laura C., Fareh, Mohamed, Hu, Wenxin, Sozzi, Vitina, Makhlouf, Christina, Droungas, Yianni, Lee, Chee Leng, Takawy, Mina, Fabb, Stewart A., Payne, Thomas J., Pouton, Colin W., Netter, Hans J., Lewin, Sharon R., Purcell, Damian FJ, Holmes, Jacinta A., Trapani, Joseph A., Littlejohn, Margaret, Revill, Peter A.

“…New antiviral approaches that target multiple aspects of the HBV replication cycle to improve rates of functional cure are urgently required. HBV RNA…”
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The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network by Fareh, M, Turchi, L, Virolle, V, Debruyne, D, Almairac, F, de-la-Forest Divonne, S, Paquis, P, Preynat-Seauve, O, Krause, K-H, Chneiweiss, H, Virolle, T

“…Glioblastoma multiforme (GBM) is the most common form of primary brain tumor in adults, often characterized by poor survival. Glioma-initiating cells (GiCs)…”
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Single-Molecule Fluorescence Study of RNA Recognition by Viral RNAi Suppressors by Fareh, Mohamed, van Lopik, Jasper, Katechis, Iason, van Rij, Ronald, Joo, Chirlmin

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Single-molecule pull-down for investigating protein–nucleic acid interactions by Fareh, Mohamed, Loeff, Luuk, Szczepaniak, Malwina, Haagsma, Anna C., Yeom, Kyu-Hyeon, Joo, Chirlmin

“…•Single-molecule pull-down provides a real-time view of the interactions between protein complexes and nucleic acids.•Single-molecule pull-down can be used to…”
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A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma by El-Habr, Elias A., Dubois, Luiz G., Burel-Vandenbos, Fanny, Bogeas, Alexandra, Lipecka, Joanna, Turchi, Laurent, Lejeune, François-Xavier, Coehlo, Paulo Lucas Cerqueira, Yamaki, Tomohiro, Wittmann, Bryan M., Fareh, Mohamed, Mahfoudhi, Emna, Janin, Maxime, Narayanan, Ashwin, Morvan-Dubois, Ghislaine, Schmitt, Charlotte, Verreault, Maité, Oliver, Lisa, Sharif, Ariane, Pallud, Johan, Devaux, Bertrand, Puget, Stéphanie, Korkolopoulou, Penelope, Varlet, Pascale, Ottolenghi, Chris, Plo, Isabelle, Moura-Neto, Vivaldo, Virolle, Thierry, Chneiweiss, Hervé, Junier, Marie-Pierre

“…Cell populations with differing proliferative, stem-like and tumorigenic states co-exist in most tumors and especially malignant gliomas. Whether metabolic…”
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Bringing single-molecule spectroscopy to macromolecular protein complexes by Joo, Chirlmin, Fareh, Mohamed, Narry Kim, V.

“…Single-molecule fluorescence spectroscopy offers real-time, nanometer-resolution information. Over the past two decades, this emerging single-molecule…”
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Viral suppressors of RNAi employ a rapid screening mode to discriminate viral RNA from cellular small RNA by Fareh, Mohamed, van Lopik, Jasper, Katechis, Iason, Bronkhorst, Alfred W, Haagsma, Anna C, van Rij, Ronald P, Joo, Chirlmin

“…Abstract RNA interference (RNAi) is an indispensable mechanism for antiviral defense in insects, including mosquitoes that transmit human diseases. To escape…”
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De novo design of CRISPR-Cas13b enables efficient silencing of SARS-CoV-2 variants and tumour pathogenic RNAs with near single-base precision by Hu, Wenxin, Zhao, Wei, Kumar, Amit, Singh, Gurjeet Jagjeet, Qi, Shijiao, Casan, Josh, Shembery, Carolyn, Fong, Danielle, Zerbato, Jennifer M., Symons, Jori, Rudraraju, Rajeev, Purcell, Damian, Haber, Michelle, Voskoboinik, Ilia, Ekert, Paul G., Lewin, Sharon, Trapani, Joseph, Fareh, Mohamed

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